View source for Hip-1

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==Overview==
'''Huntingtin Interacting Protein''' or '''Hip-1''' for short is a protein that interacts with the [[huntingtin]] [[protein]]. It is known to contain a [[protein domain|domain]] homologous to the [[death effector domain]]s (DED) found on proteins involved in [[apoptosis]]. It is believed that accumulation of high levels of the free form of this protein in the cell is one of the mechanisms by which [[neuron]] [[cell death]] is caused in [[Huntington's Disease]] (via the [[caspase]]-3 route).



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