View source for HIV coinfection with tuberculosis natural history, complications and prognosis

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{{HIV coinfection with tuberculosis}}

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==Natural History==
Until the a couple of years ago Tuberculosis was visualised in a dichotomous state of Latent phase or Active disease.But with the recent advances in the Imaging modalities and screening tests TB is conceptualized as a continuous spectrum of disease stages from latent to subclinical to symptomatic, active disease.
*In people with HIV and Mild immuno-suppression ,it usually presents as in people without hiv i.e as pulmonary tuberculosis.
*People with HIV infection who have severe immunosuppression (CD4+ T-lymphocyte count, <200 per microliter)most commonly present to the clinic with Extra Pulmonary Tuberculosis.The most common sites being Lymph nodes,Liver,Spleen, Serosal surfaces ( resulting in Effusions) and CNS.

People with severe immunosuppreession can have accelerated progression of disease course and many a times it mimics  acute bacterial infections.

==References==

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[[Category:Disease]]

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