View source for HARS2

{{Infobox_gene}}
'''Probable [[histidyl-tRNA synthetase]], [[mitochondria]]l''' is an [[enzyme]] that in [[human]]s is encoded by the ''HARS2'' [[gene]].<ref name="pmid7755634">{{cite journal |vauthors=O'Hanlon TP, Raben N, Miller FW | title = A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS | journal = Biochem Biophys Res Commun | volume = 210 | issue = 2 | pages = 556–66 |date=Jun 1995 | pmid = 7755634 | pmc =  | doi =10.1006/bbrc.1995.1696  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23438| accessdate = }}</ref>

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{{PBB_Summary
| section_title = 
| summary_text = [[Aminoacyl tRNA synthetase|Aminoacyl-tRNA synthetases]] are a class of enzymes that charge [[tRNA]]s with their cognate [[amino acids]]. The [[protein]] encoded by this gene is an enzyme belonging to the class II family of [[aminoacyl-tRNA]] [[synthetase]]s. Functioning in the [[RNA synthesis|synthesis]] of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of [[protein biosynthesis]]. The gene is located in a head-to-head orientation with HARS on [[chromosome five]], where the homologous genes share a bidirectional promoter.<ref name="entrez">{{cite web | title = Entrez Gene: HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23438| accessdate = }}</ref>
}}

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal   |vauthors=Freist W, Verhey JF, Rühlmann A, etal |title=Histidyl-tRNA synthetase. |journal=Biol. Chem. |volume=380 |issue= 6 |pages= 623–46 |year= 1999 |pmid= 10430027 |doi=10.1515/BC.1999.079  }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Lama J, Trono D |title=Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3. |journal=J. Virol. |volume=72 |issue= 2 |pages= 1671–6 |year= 1998 |pmid= 9445076 |doi=  | pmc=124654  }}
*{{cite journal   |vauthors=Tsui HW, Mok S, de Souza L, etal |title=Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element. |journal=Gene |volume=131 |issue= 2 |pages= 201–8 |year= 1993 |pmid= 8406012 |doi=10.1016/0378-1119(93)90294-D  }}
*{{cite journal   |vauthors=Raben N, Borriello F, Amin J, etal |title=Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases. |journal=Nucleic Acids Res. |volume=20 |issue= 5 |pages= 1075–81 |year= 1992 |pmid= 1549469 |doi=10.1093/nar/20.5.1075  | pmc=312093  }}
}}
{{refend}}

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