View source for EPH receptor B1

{{Infobox_gene}}
'''Ephrin type-B receptor 1''' is a [[protein]] that in humans is encoded by the ''EPHB1'' [[gene]].<ref name="pmid8666391">{{cite journal | vauthors = Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE, Ikegaki N | title = cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain | journal = Genomics | volume = 29 | issue = 2 | pages = 426–37 | year = 1995 | pmid = 8666391 | pmc =  | doi = 10.1006/geno.1995.9985 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EPHB1 EPH receptor B1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2047| accessdate = }}</ref>

== Function ==

Ephrin receptors and their ligands, the [[ephrin]]s, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.<ref name="entrez"/>

== Interactions ==

EPH receptor B1 has been shown to [[Protein-protein interaction|interact]] with:
* [[ACP1]],<ref name = pmid9499402>{{cite journal | vauthors = Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO | title = Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses | journal = Genes Dev. | volume = 12 | issue = 5 | pages = 667–78  | date = Mar 1998 | pmid = 9499402 | pmc = 316584 | doi =  10.1101/gad.12.5.667}}</ref> 
* [[GRB7]],<ref name = pmid12223469>{{cite journal | vauthors = Han DC, Shen TL, Miao H, Wang B, Guan JL | title = EphB1 associates with Grb7 and regulates cell migration | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45655–61  | date = Nov 2002 | pmid = 12223469 | doi = 10.1074/jbc.M203165200 }}</ref>  and
* [[NCK1]].<ref name = pmid9430661>{{cite journal | vauthors = Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO | title = Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase | journal = J. Biol. Chem. | volume = 273 | issue = 3 | pages = 1303–8  | date = Jan 1998 | pmid = 9430661 | doi =  10.1074/jbc.273.3.1303}}</ref>

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Flanagan JG, Vanderhaeghen P | title = The ephrins and Eph receptors in neural development | journal = Annu. Rev. Neurosci. | volume = 21 | issue =  | pages = 309–45 | year = 1998 | pmid = 9530499 | doi = 10.1146/annurev.neuro.21.1.309 }}
* {{cite journal | vauthors = Zhou R | title = The Eph family receptors and ligands | journal = Pharmacol. Ther. | volume = 77 | issue = 3 | pages = 151–81 | year = 1998 | pmid = 9576626 | doi = 10.1016/S0163-7258(97)00112-5 }}
* {{cite journal | vauthors = Abrahamson DR, Robert B, Hyink DP, St John PL, Daniel TO | title = Origins and formation of microvasculature in the developing kidney | journal = Kidney Int. Suppl. | volume = 67 | issue =  | pages = S7-11 | year = 1998 | pmid = 9736245 | doi = 10.1046/j.1523-1755.1998.06702.x }}
* {{cite journal | vauthors = Holder N, Klein R | title = Eph receptors and ephrins: effectors of morphogenesis | journal = Development | volume = 126 | issue = 10 | pages = 2033–44 | year = 1999 | pmid = 10207129 | doi =  }}
* {{cite journal | vauthors = Wilkinson DG | title = Eph receptors and ephrins: regulators of guidance and assembly | journal = Int. Rev. Cytol. | volume = 196 | issue =  | pages = 177–244 | year = 2000 | pmid = 10730216 | doi = 10.1016/S0074-7696(00)96005-4 }}
* {{cite journal | vauthors = Xu Q, Mellitzer G, Wilkinson DG | title = Roles of Eph receptors and ephrins in segmental patterning | journal = Philos. Trans. R. Soc. Lond. B Biol. Sci. | volume = 355 | issue = 1399 | pages = 993–1002 | year = 2000 | pmid = 11128993 | pmc = 1692797 | doi = 10.1098/rstb.2000.0635 }}
* {{cite journal | vauthors = Wilkinson DG | title = Multiple roles of EPH receptors and ephrins in neural development | journal = Nat. Rev. Neurosci. | volume = 2 | issue = 3 | pages = 155–64 | year = 2001 | pmid = 11256076 | doi = 10.1038/35058515 }}
* {{cite journal | vauthors = Larose L, Gish G, Shoelson S, Pawson T | title = Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1 | journal = Oncogene | volume = 8 | issue = 9 | pages = 2493–9 | year = 1993 | pmid = 7689724 | doi =  }}
* {{cite journal | vauthors = Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M, Yancopoulos GD | title = Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity | journal = Science | volume = 266 | issue = 5186 | pages = 816–9 | year = 1994 | pmid = 7973638 | doi = 10.1126/science.7973638 }}
* {{cite journal | vauthors = Beckmann MP, Cerretti DP, Baum P, Vanden Bos T, James L, Farrah T, Kozlosky C, Hollingsworth T, Shilling H, Maraskovsky E | title = Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors | journal = EMBO J. | volume = 13 | issue = 16 | pages = 3757–62 | year = 1994 | pmid = 8070404 | pmc = 395287 | doi =  }}
* {{cite journal | vauthors = Cerretti DP, Vanden Bos T, Nelson N, Kozlosky CJ, Reddy P, Maraskovsky E, Park LS, Lyman SD, Copeland NG, Gilbert DJ | title = Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases | journal = Mol. Immunol. | volume = 32 | issue = 16 | pages = 1197–205 | year = 1995 | pmid = 8559144 | doi = 10.1016/0161-5890(95)00108-5 }}
* {{cite journal | vauthors = Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD | title = Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis | journal = Neuron | volume = 17 | issue = 1 | pages = 9–19 | year = 1996 | pmid = 8755474 | doi = 10.1016/S0896-6273(00)80276-7 }}
* {{cite journal | vauthors = Stein E, Cerretti DP, Daniel TO | title = Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells | journal = J. Biol. Chem. | volume = 271 | issue = 38 | pages = 23588–93 | year = 1996 | pmid = 8798570 | doi = 10.1074/jbc.271.38.23588 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Kozlosky CJ, VandenBos T, Park L, Cerretti DP, Carpenter MK | title = LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain | journal = Cytokine | volume = 9 | issue = 8 | pages = 540–9 | year = 1997 | pmid = 9245480 | doi = 10.1006/cyto.1997.0199 }}
* {{cite journal | vauthors = Ephnomenclaturecommittee, | title = Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee | journal = Cell | volume = 90 | issue = 3 | pages = 403–4 | year = 1997 | pmid = 9267020 | doi = 10.1016/S0092-8674(00)80500-0 }}
* {{cite journal | vauthors = Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO | title = Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase | journal = J. Biol. Chem. | volume = 273 | issue = 3 | pages = 1303–8 | year = 1998 | pmid = 9430661 | doi = 10.1074/jbc.273.3.1303 }}
* {{cite journal | vauthors = Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO | title = Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses | journal = Genes Dev. | volume = 12 | issue = 5 | pages = 667–78 | year = 1998 | pmid = 9499402 | pmc = 316584 | doi = 10.1101/gad.12.5.667 }}
{{refend}}

{{PDB Gallery|geneid=2047}}

{{Tyrosine kinases}}
{{Growth factor receptor modulators}}


{{protein-stub}}