View source for Binswanger's disease

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{{Infobox_Disease |
  Name           = {{PAGENAME}} |
  Image          = |
  Caption        = |
  DiseasesDB     = 1405 |
  ICD10          = {{ICD10|I|67|3|i|60}} |
  ICD9           = {{ICD9|290.12}} |
  ICDO           = |
  OMIM           = |
  MedlinePlus    = |
  MeshID         = D015140 |
}}
{{SI}}
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'''''Synonyms and keywords:''''' Subcortical leukoencephalopathy; progressive vascular leukoencephalopathy; subcortical arteriosclerotic encephalopathy

==Overview==
Binswanger's disease is a rare form of [[multi-infarct dementia]] caused by damage to deep [[white matter|white brain matter]]. It is characterized by [[memory loss]] and intellectual function and by changes in mood.  It is associated with longstanding [[hypertension]].

==Pathophysiology==
The [[histology|histologic]] findings are diffuse, irregular loss of [[axons]] and [[myelin]] accompanied by widespread [[gliosis]]. Small [[infarct]]s may be seen in the [[frontal lobes]]. The [[pathology|pathologic]] mechanism may be damage caused by severe [[atherosclerosis]].

A patient with long term severe hypertension develops progressive [[dementia]].
==Risk Factors==
[[Hypertension]]

==Diagnosis==
===CT===
[[Computed axial tomography|CT scans]] of the head demonstrates a diffuse loss of deep hemispheric [[white matter]].

==Treatment==
Binswanger's disease has no known treatment, let alone cure, although drugs used to treat [[high blood pressure]], [[clinical depression|depression]], [[arrhythmia]] and [[low blood pressure]] are used to treat the condition's symptoms.<ref>{{NINDS|binswangers}}</ref>

==References==
{{reflist|2}}

{{Circulatory system pathology}}

[[Category:Neurology]]
[[Category:Psychiatry]]
[[Category:Cognitive disorders]]

[[de:Subkortikale arteriosklerotische Enzephalopathie]]
[[no:Binswangers sykdom]]
[[fi:Binswangerin tauti]]


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