View source for B cell scaffold protein with ankyrin repeats 1

{{Infobox_gene}}

'''B cell scaffold protein with ankyrin repeats 1''' is a [[protein]] that in humans is encoded by the BANK1 [[gene]].
<ref name="entrez">
{{cite web
| title = Entrez Gene: B cell scaffold protein with ankyrin repeats 1
| url = https://www.ncbi.nlm.nih.gov/gene/55024
| accessdate = 2018-06-04
}}</ref>

==Function==

The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

== References ==

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== Further reading ==

{{refbegin | 2}}
*{{cite journal |vauthors=Kozyrev SV, Abelson AK, Wojcik J, Zaghlool A, Linga Reddy MV, Sanchez E, Gunnarsson I, Svenungsson E, Sturfelt G, Jönsen A, Truedsson L, Pons-Estel BA, Witte T, D'Alfonso S, Barizzone N, Barrizzone N, Danieli MG, Gutierrez C, Suarez A, Junker P, Laustrup H, González-Escribano MF, Martin J, Abderrahim H, Alarcón-Riquelme ME |title=Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus |journal=Nat. Genet. |volume=40 |issue=2 |pages=211–6 |date=February 2008 |pmid=18204447 |doi=10.1038/ng.79 |url=}}
*{{cite journal |vauthors=Kozyrev SV, Abelson AK, Wojcik J, Zaghlool A, Linga Reddy MV, Sanchez E, Gunnarsson I, Svenungsson E, Sturfelt G, Jönsen A, Truedsson L, Pons-Estel BA, Witte T, D'Alfonso S, Barizzone N, Barrizzone N, Danieli MG, Gutierrez C, Suarez A, Junker P, Laustrup H, González-Escribano MF, Martin J, Abderrahim H, Alarcón-Riquelme ME |title=Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus |journal=Nat. Genet. |volume=40 |issue=2 |pages=211–6 |date=February 2008 |pmid=18204447 |doi=10.1038/ng.79 |url=}}
*{{cite journal |vauthors=Fung EY, Smyth DJ, Howson JM, Cooper JD, Walker NM, Stevens H, Wicker LS, Todd JA |title=Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus |journal=Genes Immun. |volume=10 |issue=2 |pages=188–91 |date=March 2009 |pmid=19110536 |doi=10.1038/gene.2008.99 |url=}}
*{{cite journal |vauthors=Orozco G, Abelson AK, González-Gay MA, Balsa A, Pascual-Salcedo D, García A, Fernández-Gutierrez B, Petersson I, Pons-Estel B, Eimon A, Paira S, Scherbarth HR, Alarcón-Riquelme M, Martín J |title=Study of functional variants of the BANK1 gene in rheumatoid arthritis |journal=Arthritis Rheum. |volume=60 |issue=2 |pages=372–9 |date=February 2009 |pmid=19180476 |doi=10.1002/art.24244 |url=}}
*{{cite journal |vauthors=Orozco G, Abelson AK, González-Gay MA, Balsa A, Pascual-Salcedo D, García A, Fernández-Gutierrez B, Petersson I, Pons-Estel B, Eimon A, Paira S, Scherbarth HR, Alarcón-Riquelme M, Martín J |title=Study of functional variants of the BANK1 gene in rheumatoid arthritis |journal=Arthritis Rheum. |volume=60 |issue=2 |pages=372–9 |date=February 2009 |pmid=19180476 |doi=10.1002/art.24244 |url=}}
*{{cite journal |vauthors=Guo L, Deshmukh H, Lu R, Vidal GS, Kelly JA, Kaufman KM, Dominguez N, Klein W, Kim-Howard X, Bruner GR, Scofield RH, Moser KL, Gaffney PM, Dozmorov IM, Gilkeson GS, Wakeland EK, Li QZ, Langefeld CD, Marion MC, Williams AH, Divers J, Alarcón GS, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Reveille JD, McGwin G, Vilá LM, Petri MA, Vyse TJ, Merrill JT, James JA, Nath SK, Harley JB, Guthridge JM |title=Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population |journal=Genes Immun. |volume=10 |issue=5 |pages=531–8 |date=July 2009 |pmid=19339986 |pmc=2736873 |doi=10.1038/gene.2009.18 |url=}}
*{{cite journal |vauthors=Guo L, Deshmukh H, Lu R, Vidal GS, Kelly JA, Kaufman KM, Dominguez N, Klein W, Kim-Howard X, Bruner GR, Scofield RH, Moser KL, Gaffney PM, Dozmorov IM, Gilkeson GS, Wakeland EK, Li QZ, Langefeld CD, Marion MC, Williams AH, Divers J, Alarcón GS, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Reveille JD, McGwin G, Vilá LM, Petri MA, Vyse TJ, Merrill JT, James JA, Nath SK, Harley JB, Guthridge JM |title=Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population |journal=Genes Immun. |volume=10 |issue=5 |pages=531–8 |date=July 2009 |pmid=19339986 |pmc=2736873 |doi=10.1038/gene.2009.18 |url=}}
*{{cite journal |vauthors=Chang YK, Yang W, Zhao M, Mok CC, Chan TM, Wong RW, Lee KW, Mok MY, Wong SN, Ng IO, Lee TL, Ho MH, Lee PP, Wong WH, Lau CS, Sham PC, Lau YL |title=Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese |journal=Genes Immun. |volume=10 |issue=5 |pages=414–20 |date=July 2009 |pmid=19357697 |pmc=2834352 |doi=10.1038/gene.2009.16 |url=}}
*{{cite journal |vauthors=Chang YK, Yang W, Zhao M, Mok CC, Chan TM, Wong RW, Lee KW, Mok MY, Wong SN, Ng IO, Lee TL, Ho MH, Lee PP, Wong WH, Lau CS, Sham PC, Lau YL |title=Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese |journal=Genes Immun. |volume=10 |issue=5 |pages=414–20 |date=July 2009 |pmid=19357697 |pmc=2834352 |doi=10.1038/gene.2009.16 |url=}}

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