View source for EMR3

{{Infobox_gene}}
'''EGF-like module-containing mucin-like hormone receptor-like 3''' is a [[protein]] encoded by the ''ADGRE3'' [[gene]].<ref name="pmid11279179">{{cite journal | vauthors = Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ | title = Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 18863–70 | date = Jun 2001 | pmid = 11279179 | pmc =  | doi = 10.1074/jbc.M101147200 }}</ref><ref>{{cite journal|last1=Hamann|first1=J|last2=Aust|first2=G|last3=Araç|first3=D|last4=Engel|first4=FB|last5=Formstone|first5=C|last6=Fredriksson|first6=R|last7=Hall|first7=RA|last8=Harty|first8=BL|last9=Kirchhoff|first9=C|last10=Knapp|first10=B|last11=Krishnan|first11=A|last12=Liebscher|first12=I|last13=Lin|first13=HH|last14=Martinelli|first14=DC|last15=Monk|first15=KR|last16=Peeters|first16=MC|last17=Piao|first17=X|last18=Prömel|first18=S|last19=Schöneberg|first19=T|last20=Schwartz|first20=TW|last21=Singer|first21=K|last22=Stacey|first22=M|last23=Ushkaryov|first23=YA|last24=Vallon|first24=M|last25=Wolfrum|first25=U|last26=Wright|first26=MW|last27=Xu|first27=L|last28=Langenhan|first28=T|last29=Schiöth|first29=HB|title=International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.|journal=Pharmacological Reviews|date=April 2015|volume=67|issue=2|pages=338–67|pmid=25713288|doi=10.1124/pr.114.009647|pmc=4394687}}</ref> EMR3 is a member of the [[adhesion-GPCRs|adhesion GPCR]] family.<ref name="isbn1-4419-7912-3">{{cite book | author = Stacey M, Yona S | title = Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology) | publisher = Springer | location = Berlin | year = 2011 | pages = | isbn = 1-4419-7912-3 }}</ref><ref>{{cite journal|last1=Langenhan|first1=T|last2=Aust|first2=G|last3=Hamann|first3=J|title=Sticky signaling--adhesion class G protein-coupled receptors take the stage.|journal=Science signaling|date=21 May 2013|volume=6|issue=276|pages=re3|pmid=23695165|doi=10.1126/scisignal.2003825}}</ref>
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing [[GAIN domain|(GAIN)]] domain.<ref name="pmid22333914">{{cite journal | vauthors = Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT | title = A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis | journal = The EMBO Journal | volume = 31 | issue = 6 | pages = 1364–78 | date = Mar 2012 | pmid = 22333914 | pmc = 3321182 | doi = 10.1038/emboj.2012.26 }}</ref>

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.<ref>{{cite journal | vauthors = Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J | title = The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes | journal = Journal of Leukocyte Biology | volume = 81 | issue = 2 | pages = 440–8 | date = Feb 2007 | pmid = 17108056 | doi = 10.1189/jlb.0406276 }}</ref> Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.<ref name="ReferenceA">{{cite journal | vauthors = Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ | title = Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 18863–70 | date = Jun 2001 | pmid = 11279179 | doi = 10.1074/jbc.M101147200 }}</ref> Mice, next to Emr2, lack the Emr3 gene.<ref>{{cite journal | vauthors = Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J | title = An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2 | journal = FASEB Journal | volume = 20 | issue = 14 | pages = 2582–4 | date = Dec 2006 | pmid = 17068111 | doi = 10.1096/fj.06-6500fje }}</ref>

== Function ==

The protein may play a role in [[myeloid]]-myeloid interactions during immune and inflammatory responses.<ref name="entrez">{{cite web | title = Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84658| accessdate = }}</ref>

== Ligands ==
A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.<ref name="ReferenceA"/>

== References ==
{{reflist}}

== External links ==
* [http://www.adhesiongpcr.org/Adhesion GPCR consortium]

{{G protein-coupled receptors}}

[[Category:G protein coupled receptors]]