Trioxsalen

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Trioxsalen
Names
	IUPAC name 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
Identifiers
CAS Number	3902-71-4 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:28329 ;
ChEMBL	ChEMBL1475 ;
ChemSpider	5383 ;
DrugBank	DB04571 ;
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG	D01034 ;
PubChem CID	5585;
UNII	Y6UY8OV51T ;
	InChI InChI=1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3 Key: FMHHVULEAZTJMA-UHFFFAOYSA-N ; InChI=1/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3 Key: FMHHVULEAZTJMA-UHFFFAOYAF;
	SMILES O=C/3Oc2c(c1oc(cc1cc2\C(=C\3)C)C)C;
Properties
Chemical formula	C14H12O3
Molar mass	228.24328
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Trioxsalen (trimethylpsoralen, Trioxysalen or Trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo^[1] and hand eczema.^[2] After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage.^[3] The compound is also being explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.^[4]

References

↑ "Trioxsalen - Compound Summary". PubChem.
↑ Van Coevorden, AM; Kamphof, WG; Van Sonderen, E; Bruynzeel, DP; Coenraads, PJ (2004). "Comparison of oral psoralen-UV-A with a portable tanning unit at home vs hospital-administered bath psoralen-UV-A in patients with chronic hand eczema: an open-label randomized controlled trial of efficacy". Archives of dermatology. 140 (12): 1463–6. doi:10.1001/archderm.140.12.1463. PMID 15611423.
↑ Thazhathveetil, AK; Liu, ST; Indig, FE; Seidman, MM (2007). "Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation". Bioconjugate chemistry. 18 (2): 431–7. doi:10.1021/bc060309t. PMID 17373769.
↑ Higuchi, M; Yamayoshi, A; Kobori, A; Yamaoka, T; Murakami, A (2005). "Synthesis and properties of photo-reactive antisense oligonucleotides containing 2'-O-psoralen-conjugated adenosine". Nucleic acids symposium series (2004). 49 (49): 331–2. doi:10.1093/nass/49.1.331. PMID 17150768.

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[1] "Trioxsalen - Compound Summary". PubChem.

[2] Van Coevorden, AM; Kamphof, WG; Van Sonderen, E; Bruynzeel, DP; Coenraads, PJ (2004). "Comparison of oral psoralen-UV-A with a portable tanning unit at home vs hospital-administered bath psoralen-UV-A in patients with chronic hand eczema: an open-label randomized controlled trial of efficacy". Archives of dermatology. 140 (12): 1463–6. doi:10.1001/archderm.140.12.1463. PMID 15611423.

[3] Thazhathveetil, AK; Liu, ST; Indig, FE; Seidman, MM (2007). "Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation". Bioconjugate chemistry. 18 (2): 431–7. doi:10.1021/bc060309t. PMID 17373769.

[4] Higuchi, M; Yamayoshi, A; Kobori, A; Yamaoka, T; Murakami, A (2005). "Synthesis and properties of photo-reactive antisense oligonucleotides containing 2'-O-psoralen-conjugated adenosine". Nucleic acids symposium series (2004). 49 (49): 331–2. doi:10.1093/nass/49.1.331. PMID 17150768.

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Trioxsalen

Overview

References

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