Trichlorfon

Metrifonate

Clinical data
Synonyms	Trichlorphon
AHFS/Drugs.com	International Drug Names
ATC code	P02BB01 (WHO) Template:ATCvet Template:ATCvet
Pharmacokinetic data
Elimination half-life	3 hours
Identifiers
IUPAC name (RS)-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
CAS Number	52-68-6 Y
PubChem CID	5853
ChemSpider	5644
UNII	DBF2DG4G2K
KEGG	C07971 Y
ChEBI	CHEBI:6908 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C4H8Cl3O4P
Molar mass	257.436 g/mol
3D model (JSmol)	Interactive image
SMILES COP(=O)(C(C(Cl)(Cl)Cl)O)OC InChI = 1/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3
InChI InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3 Key:NFACJZMKEDPNKN-UHFFFAOYSA-N
(verify)

WikiDoc Resources for Trichlorfon
Articles
Most recent articles on Trichlorfon Most cited articles on Trichlorfon Review articles on Trichlorfon Articles on Trichlorfon in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Trichlorfon Images of Trichlorfon Photos of Trichlorfon Podcasts & MP3s on Trichlorfon Videos on Trichlorfon
Evidence Based Medicine
Cochrane Collaboration on Trichlorfon Bandolier on Trichlorfon TRIP on Trichlorfon
Clinical Trials
Ongoing Trials on Trichlorfon at Clinical Trials.gov Trial results on Trichlorfon Clinical Trials on Trichlorfon at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Trichlorfon NICE Guidance on Trichlorfon NHS PRODIGY Guidance FDA on Trichlorfon CDC on Trichlorfon
Books
Books on Trichlorfon
News
Trichlorfon in the news Be alerted to news on Trichlorfon News trends on Trichlorfon
Commentary
Blogs on Trichlorfon
Definitions
Definitions of Trichlorfon
Patient Resources / Community
Patient resources on Trichlorfon Discussion groups on Trichlorfon Patient Handouts on Trichlorfon Directions to Hospitals Treating Trichlorfon Risk calculators and risk factors for Trichlorfon
Healthcare Provider Resources
Symptoms of Trichlorfon Causes & Risk Factors for Trichlorfon Diagnostic studies for Trichlorfon Treatment of Trichlorfon
Continuing Medical Education (CME)
CME Programs on Trichlorfon
International
Trichlorfon en Espanol Trichlorfon en Francais
Business
Trichlorfon in the Marketplace Patents on Trichlorfon
Experimental / Informatics
List of terms related to Trichlorfon

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Metrifonate (INN) or trichlorfon (USAN) is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate (DDVP).

It is used as an insecticide.

It can be used to treat schistosomiasis caused by Schistoma haematobium but is no longer commercially available.

It has been proposed for use in treatment of Alzheimer's disease, but use for that purpose is not currently recommended.