CD247

2018-05-22T21:59:41Z

2607:F140:400:A004:6CE6:4EE7:349E:ECF5: /* Function */ Added a zeta symbol "ζ" since it's often used to represent this protein and wasn't present elsewhere on the page.

{{Infobox_gene}}
'''T-cell surface glycoprotein CD3 zeta chain''' also known as '''T-cell receptor T3 zeta chain''' or '''CD247''' ('''C'''luster of '''D'''ifferentiation 247) is a [[protein]] that in humans is encoded by the ''CD247'' [[gene]].<ref name="pmid2974162">{{cite journal | vauthors = Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ, Klausner RD | title = Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 85 | issue = 24 | pages = 9709–13 | date = December 1988 | pmid = 2974162 | pmc = 282845 | doi = 10.1073/pnas.85.24.9709 }}</ref>

== Genomics ==

The gene is located on the long arm of [[chromosome 1]] at location 1q22-q25 on the [[Sense (molecular biology)|Crick (negative) strand]]. The gene is 87,896 bases in length. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kilo[[Dalton (unit)|Daltons]].

== Function ==

[[T cell receptor|T-cell receptor]] zeta (ζ), together with T-cell receptor alpha/beta and gamma/delta heterodimers and [[CD3 (immunology)|CD3]]-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: CD247 CD247 molecule| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=919| accessdate = }}</ref>

== Interactions ==

CD247 has been shown to [[Protein-protein interaction|interact]] with [[Janus kinase 3]]<ref name=pmid11349123>{{cite journal | vauthors = Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T | title = Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex | journal = J. Biol. Chem. | volume = 276 | issue = 27 | pages = 25378–85 | date = Jul 2001 | pmid = 11349123 | doi = 10.1074/jbc.M011363200 }}</ref> and [[Protein unc-119 homolog]].<ref name=pmid14757743>{{cite journal | vauthors = Gorska MM, Stafford SJ, Cen O, Sur S, Alam R | title = Unc119, a novel activator of Lck/Fyn, is essential for T cell activation | journal = J. Exp. Med. | volume = 199 | issue = 3 | pages = 369–79 | date = Feb 2004 | pmid = 14757743 | pmc = 2211793 | doi = 10.1084/jem.20030589 }}</ref>

== See also ==
* [[Cluster of differentiation]]
* [[ZAP70]]

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Geyer M, Fackler OT, Peterlin BM | title = Structure--function relationships in HIV-1 Nef. | journal = EMBO Rep. | volume = 2 | issue = 7 | pages = 580–5 | year = 2001 | pmid = 11463741 | pmc = 1083955 | doi = 10.1093/embo-reports/kve141 }}
* {{cite journal | vauthors = Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M | title = HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication. | journal = J. Biosci. | volume = 28 | issue = 3 | pages = 323–35 | year = 2004 | pmid = 12734410 | doi = 10.1007/BF02970151 }}
* {{cite journal | vauthors = Stove V, Verhasselt B | title = Modelling thymic HIV-1 Nef effects. | journal = Curr. HIV Res. | volume = 4 | issue = 1 | pages = 57–64 | year = 2006 | pmid = 16454711 | doi = 10.2174/157016206775197583 }}
{{refend}}

== External links ==
* {{MeshName|CD247+protein,+human}}
* {{UCSC gene info|CD247}}

{{PDB Gallery|geneid=919}}
{{Clusters of differentiation}}

[[Category:Clusters of differentiation]]

{{membrane-protein-stub}}

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CD247