https://www.wikidoc.org/api.php?action=feedcontributions&feedformat=atom&user=2600%3A8802%3A540A%3A1600%3ADDF4%3A137E%3A5B79%3AB72wikidoc - User contributions [en]2026-04-08T13:15:35ZUser contributionsMediaWiki 1.45.1https://www.wikidoc.org/index.php?title=SAR1A&diff=1414157SAR1A2017-03-23T07:04:36Z<p>2600:8802:540A:1600:DDF4:137E:5B79:B72: Described the type of GTPase Sar1 is (monomeric)</p>
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<div>{{infobox protein<br />
|name=SAR1 homolog A (S. cerevisiae)<br />
|caption=<br />
|image=<br />
|width=<br />
|HGNCid=10534<br />
|Symbol=SAR1A<br />
|AltSymbols=SARA1<br />
|EntrezGene=56681<br />
|OMIM=607691<br />
|RefSeq=<br />
|UniProt=<br />
|PDB=<br />
|ECnumber=<br />
|Chromosome=10<br />
|Arm=q<br />
|Band=22.1<br />
|LocusSupplementaryData=<br />
}}<br />
'''SAR1A''' or '''Sar1''' is a protein involved in membrane trafficking. It is a [[GTPase|monomeric small GTPase]] found in [[COPII|COPII vesicles]]. It regulates the assembly and disassembly of COPII coats.<br />
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[[GDP]]-bound Sar1 interacts with the membrane-bound exchange factor [[Sec12]] and exchanges its bound GDP for GTP. The [[hydrophobic]] [[N-terminus]] of Sar1-GTP then locates it to the membrane, where it serves as the binding site for the [[Sec23]]/[[Sec24]] protein coat complex. After the vesicle coat is completely assembled and the vesicle is released from the donor membrane, the [[Sec23]] subunit promotes Sar1 GTPase activity, which triggers the disassembly of the COPII coat.<br />
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==See also==<br />
*[[ADP ribosylation factor|ARF]]<br />
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==External links==<br />
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{{Vesicular transport proteins}}<br />
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[[Category:Biomolecules]]<br />
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{{biochem-stub}}</div>2600:8802:540A:1600:DDF4:137E:5B79:B72