https://www.wikidoc.org/api.php?action=feedcontributions&feedformat=atom&user=2405%3A205%3AA089%3AC68D%3A2A4E%3AED8%3A71B%3A2960 wikidoc - User contributions [en] 2026-04-09T06:34:32Z User contributions MediaWiki 1.45.1 https://www.wikidoc.org/index.php?title=HPR_(gene)&diff=1417406 HPR (gene) 2017-10-31T05:19:59Z <p>2405:205:A089:C68D:2A4E:ED8:71B:2960: </p> <hr /> <div>{{Infobox_gene}}<br /> '''laxman ''' is a [[protein]] that in humans is encoded by the ''HPR'' [[gene]].&lt;ref name=&quot;pmid2987228&quot;&gt;{{cite journal | author = Maeda N | title = Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element | journal = J Biol Chem | volume = 260 | issue = 11 | pages = 6698–709 |date=Jul 1985 | pmid = 2987228 | pmc = | doi = }}&lt;/ref&gt;&lt;ref name=&quot;pmid16778136&quot;&gt;{{cite journal |vauthors=Nielsen MJ, Petersen SV, Jacobsen C, Oxvig C, Rees D, Moller HJ, Moestrup SK | title = Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein | journal = Blood | volume = 108 | issue = 8 | pages = 2846–9 |date=Oct 2006 | pmid = 16778136 | pmc = | doi = 10.1182/blood-2006-05-022327 }}&lt;/ref&gt;&lt;ref name=&quot;entrez&quot;&gt;{{cite web | title = Entrez Gene: HPR haptoglobin-related protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&amp;Cmd=ShowDetailView&amp;TermToSearch=3250| accessdate = }}&lt;/ref&gt; The HPR gene affects hereditary immunity to a non-pathogenic species of African [[Trypanosoma|trypanosomes]].&lt;ref name=&quot;pmid7716520&quot;&gt;{{cite journal |vauthors=Smith AB, Esko JD, Hajduk SL |title=Killing of trypanosomes by the human haptoglobin-related protein. |journal=Science |volume=268 |issue= 5208 |pages= 284–6 |year= 1995 |pmid= 7716520 |doi=10.1126/science.7716520 }}&lt;/ref&gt;<br /> <br /> ==See also==<br /> * [[Haptoglobin]]<br /> * [[Trypanosoma brucei#Killing by human serum and resistance to human serum killing|''Trypanosoma brucei'': Killing by human serum and resistance to human serum killing]]<br /> <br /> ==References==<br /> {{reflist}}<br /> <br /> ==Further reading==<br /> {{refbegin | 2}}<br /> *{{cite journal |vauthors=Erickson LM, Kim HS, Maeda N |title=Junctions between genes in the haptoglobin gene cluster of primates. |journal=Genomics |volume=14 |issue= 4 |pages= 948–58 |year= 1993 |pmid= 1478675 |doi=10.1016/S0888-7543(05)80116-8 }}<br /> *{{cite journal |vauthors=Maeda N, McEvoy SM, Harris HF, etal |title=Polymorphisms in the human haptoglobin gene cluster: chromosomes with multiple haptoglobin-related (Hpr) genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 19 |pages= 7395–9 |year= 1986 |pmid= 2876426 |doi=10.1073/pnas.83.19.7395 | pmc=386724 }}<br /> *{{cite journal |vauthors=Bensi G, Raugei G, Klefenz H, Cortese R |title=Structure and expression of the human haptoglobin locus. |journal=EMBO J. |volume=4 |issue= 1 |pages= 119–26 |year= 1985 |pmid= 4018023 |doi= | pmc=554159 }}<br /> *{{cite journal |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 }}<br /> *{{cite journal |vauthors=Tabak S, Lev A, Valansi C, etal |title=Transcriptionally active haptoglobin-related (Hpr) gene in hepatoma G2 and leukemia molt-4 cells. |journal=DNA Cell Biol. |volume=15 |issue= 11 |pages= 1001–7 |year= 1997 |pmid= 8945641 |doi=10.1089/dna.1996.15.1001 }}<br /> *{{cite journal |vauthors=Muranjan M, Nussenzweig V, Tomlinson S |title=Characterization of the human serum trypanosome toxin, haptoglobin-related protein. |journal=J. Biol. Chem. |volume=273 |issue= 7 |pages= 3884–7 |year= 1998 |pmid= 9461571 |doi=10.1074/jbc.273.7.3884 }}<br /> *{{cite journal |vauthors=Raper J, Fung R, Ghiso J, etal |title=Characterization of a novel trypanosome lytic factor from human serum. |journal=Infect. Immun. |volume=67 |issue= 4 |pages= 1910–6 |year= 1999 |pmid= 10085035 |doi= | pmc=96545 }}<br /> *{{cite journal |vauthors=Loftus BJ, Kim UJ, Sneddon VP, etal |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927 }}<br /> *{{cite journal |vauthors=Xu XR, Huang J, Xu ZG, etal |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398 | pmc=64988 }}<br /> *{{cite journal |vauthors=Hatada S, Seed JR, Barker C, etal |title=No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein. |journal=Mol. Biochem. Parasitol. |volume=119 |issue= 2 |pages= 291–4 |year= 2002 |pmid= 11814582 |doi=10.1016/S0166-6851(01)00420-0 }}<br /> *{{cite journal |vauthors=Vanhollebeke B, Nielsen MJ, Watanabe Y, etal |title=Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 10 |pages= 4118–23 |year= 2007 |pmid= 17360487 |doi= 10.1073/pnas.0609902104 | pmc=1820718 }}<br /> *{{cite journal |vauthors=Widener J, Nielsen MJ, Shiflett A, etal |title=Hemoglobin is a co-factor of human trypanosome lytic factor. |journal=PLoS Pathog. |volume=3 |issue= 9 |pages= 1250–61 |year= 2007 |pmid= 17845074 |doi= 10.1371/journal.ppat.0030129 | pmc=1971115 }}<br /> {{refend}}<br /> <br /> <br /> {{gene-16-stub}}</div> 2405:205:A089:C68D:2A4E:ED8:71B:2960