Zofenopril: Difference between revisions

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| IUPAC_name        = (2''S'',4''S'')-1-[(2''S'')-3-(Benzoylsulfanyl)-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
| IUPAC_name        = (2''S'',4''S'')-1-[(2''S'')-3-(Benzoylsulfanyl)-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
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'''Zofenopril''' (also known as Zofenoprilum [Latin]) is an [[ACE inhibitor|angiotensin converting enzyme (ACE) inhibitor]] which is indicated for the treatment of hypertension.  
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'''Zofenopril''' (also known as Zofenoprilum [Latin]) is an [[ACE inhibitor|angiotensin converting enzyme (ACE) inhibitor]] with cardioprotective properties indicated for the treatment of hypertension.<ref>{{cite journal |author=Ambrosioni E |title=Defining the role of zofenopril in the management of hypertension and ischemic heart disorders |journal=Am J Cardiovasc Drugs |volume=7 |issue=1 |pages=17–24 |year=2007 |pmid=17355163 |doi= 10.2165/00129784-200707010-00002|url=}}</ref>
 
In small studies, zofenopril appeared [[statistical significance|significantly]] more effective than the older antihypertensives [[atenolol]] and [[enalapril]], and was associated with less [[adverse drug reaction|adverse effect]]s.<ref>{{cite journal |author=Nilsson P |title=Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension |journal=Blood Press Suppl |volume=2 |issue= |pages=25–30 |date=October 2007 |pmid=18046976 |doi= |url=}}</ref><ref>{{cite journal |author=Mallion JM |title=An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension |journal=Blood Press Suppl |volume=2 |issue= |pages=13–8 |date=October 2007 |pmid=18046974 |doi= |url=}}</ref>
 
==References==
{{Reflist|2}}


{{ACE inhibitors}}
{{ACE inhibitors}}


[[Category:ACE inhibitors]]
[[Category:ACE inhibitors]]
[[Category:Amides]]
[[Category:Pyrrolidines]]
[[Category:Cardiovascular Drugs]][[Category:Drugs]]


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Revision as of 20:02, 23 July 2014

Zofenopril
Clinical data
Routes of
administration		Oral
ATC code
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC22H23NO4S2
Molar mass429.552 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Sheng Shi, M.D. [2]

Zofenopril (also known as Zofenoprilum [Latin]) is an angiotensin converting enzyme (ACE) inhibitor with cardioprotective properties indicated for the treatment of hypertension.[1]

In small studies, zofenopril appeared significantly more effective than the older antihypertensives atenolol and enalapril, and was associated with less adverse effects.[2][3]

References

  1. ↑ Ambrosioni E (2007). "Defining the role of zofenopril in the management of hypertension and ischemic heart disorders". Am J Cardiovasc Drugs. 7 (1): 17–24. doi:10.2165/00129784-200707010-00002. PMID 17355163.
  2. ↑ Nilsson P (October 2007). "Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension". Blood Press Suppl. 2: 25–30. PMID 18046976.
  3. ↑ Mallion JM (October 2007). "An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension". Blood Press Suppl. 2: 13–8. PMID 18046974.

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