Zileuton

Zileuton
	File:Zileuton.png
	File:Zileuton.gif
Clinical data
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	Oral
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	Not yet established
Protein binding	93%
Metabolism	Hepatic (CYP1A2, CYP2C9 and CYP3A4-mediated)
Elimination half-life	2.5 hours
Excretion	Renal
Identifiers
	IUPAC name 1-(1-benzothiophen-2-ylethyl)-1-hydroxy-urea;
CAS Number	111406-87-2;
PubChem CID	60490;
DrugBank	APRD00265;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C11H12N2O2S
Molar mass	236.291 g/mol

Zileuton (INN) is an asthma drug. It blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.

Zileuton is marketed by Critical Therapeutics under the brand name Zyflo®.

External links

Clinical data
File:Zileuton.png
File:Zileuton.gif
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	Not yet established
Protein binding	93%
Metabolism	Hepatic (CYP1A2, CYP2C9 and CYP3A4-mediated)
Elimination half-life	2.5 hours
Excretion	Renal
Identifiers
IUPAC name 1-(1-benzothiophen-2-ylethyl)-1-hydroxy-urea
CAS Number	111406-87-2
PubChem CID	60490
DrugBank	APRD00265
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₁H₁₂N₂O₂S
Molar mass	236.291 g/mol