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{{Template:Esophageal stricture  (patient information)}}


{{Lymphoplasmacytic lymphoma (patient information)}}
'''For the WikiDoc page for this topic, click [[Esophageal stricture|here]]'''
 
{{CMG}}; {{AE}}


{{CMG}}; {{AE}} {{S.M.}}
==Overview==
==Overview==
Lymphoplasmacytic lymphoma is a [[cancer]] of the B [[B Lymphocytes|lymphocytes]] (a type of white blood cell). It is associated with the overproduction of [[proteins]] called [[IgM]] [[antibodies]].<ref name="urlMacroglobulinemia of Waldenstrom: MedlinePlus Medical Encyclopedia">{{cite web |url=http://www.nlm.nih.gov/medlineplus/ency/article/000588.htm |title=Macroglobulinemia of Waldenstrom: MedlinePlus Medical Encyclopedia |format= |work= |accessdate=}}</ref>
==What are the symptoms of lymphoplasmacytic lymphoma?==
* [[Bleeding of the gums]]
* [[Blurred or decreased vision]]
* [[Dizziness]]
* Easy [[bruising]] of the [[skin]]
* [[Fatigue]]
* [[Headache]]
* Mental status changes
* [[Nosebleeds]]
* [[Numbness]], [[tingling]], or burning [[pain]] in the hands, feet, fingers, toes, ears, or nose
* [[Rash]]
* Unintentional [[weight loss]]
* Vision loss in one eye


Additional symptoms that may be associated with this disease:
==What are the Symptoms of (Disease name)?==


* Bluish skin discoloration
==What Causes (disease name)?==
* Fingers that change color upon pressure
* [[Flank pain]]
* Swollen glands
==What causes lymphoplasmacytic lymphoma?==
Lymphoplasmacytic lynmphoma is a result of a condition called [[Waldenstrom macroglobulinemia]]. The cause of the overproduction of the IgM antibody is unknown, but researchers believe it is made by lymphoma cells.


Overproduction of IgM causes the blood to become too thick. This is called hyper-viscosity. It occasionally makes it harder for blood to flow through small blood vessels.
==Who is at Highest Risk?==


About 1,500 people in the United States are diagnosed with lymphoplasmacytic lymphoma every year. Most people with this condition are over age 65; however, it may also occur in younger people.
==Diagnosis==


== Diagnosis ==
==When to Seek Urgent Medical Care?==


Signs may include:
==Treatment Options==


* Swollen/[[enlarged spleen]]
==Where to find Medical Care for (Disease name)?==
* Swollen/[[enlarged liver]]
Medical care for (disease name) can be found [https://www.google.com/maps/search/hospitals/ here].
* Swollen/[[enlarged lymph nodes]]
* An eye exam may show enlarged veins in the [[retina]] or [[retinal bleeding]] ([[hemorrhages]]).


Tests may include:
==Prevention==


* [[Complete blood count]] (CBC) - shows a low number of red blood cells and [[platelets]]
==What to Expect (Outlook/Prognosis)?==
* [[Blood chemistry tests|Blood chemistry]] - evidence of [[kidney disease]]
* Serum viscosity test
* [[Serum protein electrophoresis]] - increased amount of the [[IgM]] [[antibody]]. Levels seen in Waldenstrom's macroglobulinemia are generally greater than 3 g/dL.
* [[Bone marrow examination]] - show cells that resemble both [[lymphocytes]] and [[plasma cells]]


Additional tests that may be done:
==Possible Complications==


* 24-hour urine protein
==Sources==
* [[Total protein]]
http://www.nlm.nih.gov/medlineplus/ency/article/000434.htm
* [[Electrophoresis|Serum globulin electrophoresis]]
* [[Immunofixation]] in urine
* T (thymus derived) lymphocyte count


==When to seek urgent medical care?==
Call your health care provider if any symptoms of this disorder develop.
==Treatment==
* [[Plasmapheresis]] - removes unwanted substances from the blood. In macroglobulinemia, this treatment removes or reduces the high levels of [[Immunoglobulin M|IgM]] and is used to quickly control the symptoms caused by blood thickening.
* Drug therapy - may include [[steroids]], [[Leukeran]], [[Alkeran]], [[Cytoxan]], [[fludarabine]], or [[rituximab]], or combinations of [[chemotherapy]] drugs.
* Patients who have a low number of red or [[white blood cells]] or [[platelets]] may need [[transfusions]] or [[antibiotics]].
==What to expect (Outlook/Prognosis)?==
The average survival is about 6.5 years. Some people live more than 10 years. In some people, LPL may produce few symptoms and progress slowly.
==Possible complications==
* Changes in mental function, possibly leading to [[coma]]
* [[Congestive heart failure]]
* [[Gastrointestinal bleeding]]
* [[Vision problems]]
==Sources==
{{reflist|2}}
{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category:Patient information]]

Latest revision as of 17:39, 6 May 2020

Esophageal stricture

Overview

What are the symptoms?

What are the causes?

Who is at highest risk?

Diagnosis

When to seek urgent medical care?

Treatment options

Where to find medical care for Esophageal stricture?

Prevention

What to expect (Outlook/Prognosis)?

Possible complications

Esophageal stricture On the Web

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Risk calculators and risk factors for Esophageal stricture

For the WikiDoc page for this topic, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

What are the Symptoms of (Disease name)?

What Causes (disease name)?

Who is at Highest Risk?

Diagnosis

When to Seek Urgent Medical Care?

Treatment Options

Where to find Medical Care for (Disease name)?

Medical care for (disease name) can be found here.

Prevention

What to Expect (Outlook/Prognosis)?

Possible Complications

Sources

http://www.nlm.nih.gov/medlineplus/ency/article/000434.htm

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