XPO5
| Exportin 5 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | XPO5 ; FLJ14239; FLJ32057; FLJ45606; KIAA1291 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 69316 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE XPO5 gnf1h05645 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Exportin 5, also known as XPO5, is a human gene.[1]
Exportin-5 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments.[supplied by OMIM][1]
References
Further reading
- Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.
- Nagase T, Ishikawa K, Kikuno R; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. PMID 10574462.
- Brownawell AM, Macara IG (2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins". J. Cell Biol. 156 (1): 53–64. doi:10.1083/jcb.200110082. PMID 11777942.
- Bohnsack MT, Regener K, Schwappach B; et al. (2003). "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm". EMBO J. 21 (22): 6205–15. PMID 12426392.
- Calado A, Treichel N, Müller EC; et al. (2003). "Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA". EMBO J. 21 (22): 6216–24. PMID 12426393.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gwizdek C, Ossareh-Nazari B, Brownawell AM; et al. (2003). "Exportin-5 mediates nuclear export of minihelix-containing RNAs". J. Biol. Chem. 278 (8): 5505–8. doi:10.1074/jbc.C200668200. PMID 12509441.
- Screaton RA, Kiessling S, Sansom OJ; et al. (2003). "Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis". Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5211–6. doi:10.1073/pnas.0431215100. PMID 12702765.
- Gwizdek C, Ossareh-Nazari B, Brownawell AM; et al. (2004). "Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3". J. Biol. Chem. 279 (2): 884–91. doi:10.1074/jbc.M306808200. PMID 14570900.
- Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Lund E, Güttinger S, Calado A; et al. (2004). "Nuclear export of microRNA precursors". Science. 303 (5654): 95–8. doi:10.1126/science.1090599. PMID 14631048.
- Yi R, Qin Y, Macara IG, Cullen BR (2004). "Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs". Genes Dev. 17 (24): 3011–6. doi:10.1101/gad.1158803. PMID 14681208.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bohnsack MT, Czaplinski K, Gorlich D (2004). "Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs". RNA. 10 (2): 185–91. PMID 14730017.
- Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
- Chen T, Brownawell AM, Macara IG (2004). "Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5". Mol. Cell. Biol. 24 (15): 6608–19. doi:10.1128/MCB.24.15.6608-6619.2004. PMID 15254228.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Yi R, Doehle BP, Qin Y; et al. (2005). "Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs". RNA. 11 (2): 220–6. doi:10.1261/rna.7233305. PMID 15613540.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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