X-linked dominant

Revision as of 12:16, 21 May 2009 by Swilliams (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

WikiDoc Resources for X-linked dominant

Articles

Most recent articles on X-linked dominant

Most cited articles on X-linked dominant

Review articles on X-linked dominant

Articles on X-linked dominant in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on X-linked dominant

Images of X-linked dominant

Photos of X-linked dominant

Podcasts & MP3s on X-linked dominant

Videos on X-linked dominant

Evidence Based Medicine

Cochrane Collaboration on X-linked dominant

Bandolier on X-linked dominant

TRIP on X-linked dominant

Clinical Trials

Ongoing Trials on X-linked dominant at Clinical Trials.gov

Trial results on X-linked dominant

Clinical Trials on X-linked dominant at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on X-linked dominant

NICE Guidance on X-linked dominant

NHS PRODIGY Guidance

FDA on X-linked dominant

CDC on X-linked dominant

Books

Books on X-linked dominant

News

X-linked dominant in the news

Be alerted to news on X-linked dominant

News trends on X-linked dominant

Commentary

Blogs on X-linked dominant

Definitions

Definitions of X-linked dominant

Patient Resources / Community

Patient resources on X-linked dominant

Discussion groups on X-linked dominant

Patient Handouts on X-linked dominant

Directions to Hospitals Treating X-linked dominant

Risk calculators and risk factors for X-linked dominant

Healthcare Provider Resources

Symptoms of X-linked dominant

Causes & Risk Factors for X-linked dominant

Diagnostic studies for X-linked dominant

Treatment of X-linked dominant

Continuing Medical Education (CME)

CME Programs on X-linked dominant

International

X-linked dominant en Espanol

X-linked dominant en Francais

Business

X-linked dominant in the Marketplace

Patents on X-linked dominant

Experimental / Informatics

List of terms related to X-linked dominant

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

X-linked dominant is mode of inheritance in which a gene on the X chromosome is dominant.[1] Females can be more frequently affected than males since they have two X chromosomes that could potentially carry the abnormal gene, whereas a male has only one. However, the Lyon hypothesis states that X-inactivation renders only one copy of the X chromosome active in each cell hence on average one would expect only one half of the cells to express the abnormal gene. The chance of passing on an X-linked dominant disorder differs between men and women.

As a disease inheritance pattern, it is less common than X-linked recessive.

Inheritance

Females usually have two X chromosomes, while most males have one X and one Y chromosome. If a child has inherited the mutation from the X chromosome of one of their parents they will have the condition. A woman with an X-linked dominant disorder has a 50% chance of having an affected daughter or son with each pregnancy. The sons of a man with an X-linked dominant disorder will not be affected (since they inherit their only X chromosome from their mother), but his daughters will all inherit the condition.

Some X-linked dominant conditions such as Aicardi Syndrome are fatal to boys, therefore only girls with these conditions survive. Similarly, individuals with Klinefelter's Syndrome are referred to as "47,XXY Males".

See also

References

Template:X-linked disorders Template:SIB

Template:WH Template:WS