Wilms' tumor diagnostic study of choice
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Wilms' tumor Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Diagnostic Study of Choice
Study of choice
- Histology of the biopsy sample taken during surgery is the gold standard for the diagnosis of wilms tumor.
Diagnostic results
The following result of histology is confirmatory of wilms tumor:
- Triphasic histology comprising -
- Epithelial cells
- Blastemal cells
- Stromal cells
- Anaplastic changes
- Most of the tumors of the kidney have a favorable histology(90%).
- If anaplastic changes(3-7%) are found then the outcome is poor.
Sequence of Diagnostic Studies
The surgical examination and biopsy must be performed when:
- If a case of wilms tumor is suspected in North America, then nephrectomy is done immediately.
- Contralateral kidney is also explored to check for disease and lymph node biopsies done.
- Transcutaneous biopsy samples are almost never taken to prevent:
- Tumor spill - If this occurs then whole abdomen radiotherapy has to be done.