|
|
| Line 1: |
Line 1: |
| {{CMG}}
| |
|
| |
|
|
| |
|
| | __NOTOC__ |
| | {{Venlafaxine}} |
| | {{CMG}}; {{AE}} {{SS}} |
|
| |
|
| ==Major Interactions== | | ==Drug Interactions== |
| {{refbegin|3}}
| |
| * [[5-HTP]]
| |
| * [[5-hydroxytryptophan]]
| |
| * [[Actiq]]
| |
| * [[Acutrim 16 Hour]]
| |
| * [[Acutrim II Maximum Strength]]
| |
| * [[Acutrim Late Day]]
| |
| * [[Adapin]]
| |
| * [[Adipex-P]]
| |
| * [[Adipost]]
| |
| * [[Alfenta]]
| |
| * [[alfentanil]]
| |
| * [[almotriptan]]
| |
| * [[Amerge]]
| |
| * [[amitriptyline]]
| |
| * [[amoxapine]]
| |
| * [[amphetamine]]
| |
| * [[Anafranil]]
| |
| * [[Anorex-SR]]
| |
| * [[Appecon]]
| |
| * [[Asendin]]
| |
| * [[Atapryl]]
| |
| * [[Aventyl HCl]]
| |
| * [[Axert]]
| |
| * [[Azilect]]
| |
| * [[Babee Cof]]
| |
| * [[Balminil DM]]
| |
| * [[Balminil DM Pour Enfants]]
| |
| * [[Balminil DM Sans Sucrose]]
| |
| * [[Benadryl for the Family Dry Forte]]
| |
| * [[Benylin]]
| |
| * [[Benylin Adult Formula]]
| |
| * [[Benylin DM]]
| |
| * [[Benylin DM Pediatric]]
| |
| * [[Benylin Dry Coughs]]
| |
| * [[Benylin Pediatric]]
| |
| * [[benzphetamine]]
| |
| * [[Bisolvon Dry]]
| |
| * [[Bisolvon Dry Junior]]
| |
| * [[Bontril PDM]]
| |
| * [[Bontril Slow Release]]
| |
| * [[Buckley's Mixture Cough Suppressant]]
| |
| * [[Buckleys Mixture]]
| |
| * [[Budeprion SR]]
| |
| * [[Budeprion XL]]
| |
| * [[buPROPion]]
| |
| * [[buPROPion 24 hour extended release]]
| |
| * [[buPROPion extended release]]
| |
| * [[BuSpar]]
| |
| * [[BuSpar Dividose]]
| |
| * [[busPIRone]]
| |
| * [[Calmylin]]
| |
| * [[Carbex]]
| |
| * [[Celexa]]
| |
| * [[Chem Mart Tramadol]]
| |
| * [[citalopram]]
| |
| * [[clomiPRAMINE]]
| |
| * [[Contac Cough]]
| |
| * [[Control]]
| |
| * [[Cough Syrup DM]]
| |
| * [[Covonia Bronchial Balsam]]
| |
| * [[Creo-Terpin]]
| |
| * [[Creomulsion]]
| |
| * [[Creomulsion Children]]
| |
| * [[Cymbalta]]
| |
| * [[D.H.E. 45]]
| |
| * [[Darvon]]
| |
| * [[Darvon-N]]
| |
| * [[Delsym]]
| |
| * [[Delsym 12 Hour Cough Relief]]
| |
| * [[Delsym 12 Hour Cough Relief for Children & Adults]]
| |
| * [[Demerol HCl]]
| |
| * [[desipramine]]
| |
| * [[Desoxyn]]
| |
| * [[Desoxyn Gradumet]]
| |
| * [[desvenlafaxine]]
| |
| * [[Desyrel]]
| |
| * [[Desyrel Dividose]]
| |
| * [[DexAlone]]
| |
| * [[Dexatrim]]
| |
| * [[Dexatrim Caffeine Free]]
| |
| * [[Dexedrine]]
| |
| * [[Dexedrine Spansule]]
| |
| * [[dexfenfluramine]]
| |
| * [[Dexi-Tuss]]
| |
| * [[dextroamphetamine]]
| |
| * [[dextroamphetamine extended release]]
| |
| * [[dextromethorphan]]
| |
| * [[dextromethorphan extended release]]
| |
| * [[Dextromethorphan HBr Adult Formula]]
| |
| * [[Dextrostat]]
| |
| * [[Didrex]]
| |
| * [[diethylpropion]]
| |
| * [[diethylpropion extended release]]
| |
| * [[dihydroergotamine]]
| |
| * [[dihydroergotamine nasal]]
| |
| * [[Dimetapp Cold Cough & Flu Day & Night Liquid Caps]]
| |
| * [[doxepin]]
| |
| * [[doxepin topical]]
| |
| * [[Dristan DM]]
| |
| * [[Dromadol SR]]
| |
| * [[Dromadol XL]]
| |
| * [[Dry Cough]]
| |
| * [[duloxetine]]
| |
| * [[Duragesic]]
| |
| * [[Duragesic-100]]
| |
| * [[Duragesic-12]]
| |
| * [[Duragesic-25]]
| |
| * [[Duragesic-50]]
| |
| * [[Duragesic-75]]
| |
| * [[Elavil]]
| |
| * [[Eldepryl]]
| |
| * [[eletriptan]]
| |
| * [[Elixsure Cough]]
| |
| * [[Empro]]
| |
| * [[Emsam]]
| |
| * [[Endep]]
| |
| * [[ephedra]]
| |
| * [[Ergomar]]
| |
| * [[ergonovine]]
| |
| * [[ergotamine]]
| |
| * [[Ergotrate Maleate]]
| |
| * [[escitalopram]]
| |
| * [[Eskalith]]
| |
| * [[Eskalith-CR]]
| |
| * [[Fastin]]
| |
| * [[fenfluramine]]
| |
| * [[fentanyl]]
| |
| * [[fentanyl topical]]
| |
| * [[Fentora]]
| |
| * [[fluoxetine]]
| |
| * [[fluoxetine extended release]]
| |
| * [[fluvoxamine]]
| |
| * [[fluvoxamine extended release]]
| |
| * [[Frova]]
| |
| * [[frovatriptan]]
| |
| * [[furazolidone]]
| |
| * [[Furoxone]]
| |
| * [[GenRx Tramadol]]
| |
| * [[GHB]]
| |
| * [[Hold DM]]
| |
| * [[hypericum perforatum]]
| |
| * [[imipramine]]
| |
| * [[imipramine pamoate]]
| |
| * [[Imitrex]]
| |
| * [[Imitrex Nasal]]
| |
| * [[Imitrex Statdose]]
| |
| * [[Imitrex Statdose Refill]]
| |
| * [[iohexol]]
| |
| * [[Ionamin]]
| |
| * [[Ionsys]]
| |
| * [[iopamidol]]
| |
| * [[Iopamidol-370]]
| |
| * [[isocarboxazid]]
| |
| * [[Isovue-128]]
| |
| * [[Isovue-200]]
| |
| * [[Isovue-250]]
| |
| * [[Isovue-300]]
| |
| * [[Isovue-370]]
| |
| * [[Isovue-M-200]]
| |
| * [[Isovue-M-300]]
| |
| * [[Jack & Jill Thin Strips Cough]]
| |
| * [[Jumex]]
| |
| * [[l-tryptophan]]
| |
| * [[Larapam SR]]
| |
| * [[levomethadyl acetate]]
| |
| * [[Lexapro]]
| |
| * [[linezolid]]
| |
| * [[lisdexamfetamine]]
| |
| * [[lithium]]
| |
| * [[lithium carbonate]]
| |
| * [[lithium carbonate extended release]]
| |
| * [[lithium citrate]]
| |
| * [[Lithobid]]
| |
| * [[Lithonate]]
| |
| * [[Lithotabs]]
| |
| * [[Lloydspharmacy Dry Adult Cough]]
| |
| * [[Luvox]]
| |
| * [[Luvox CR]]
| |
| * [[ma huang]]
| |
| * [[Marplan]]
| |
| * [[Matulane]]
| |
| * [[Maxalt]]
| |
| * [[Maxalt-MLT]]
| |
| * [[Mazanor]]
| |
| * [[mazindol]]
| |
| * [[Mega-Trim]]
| |
| * [[Melfiat]]
| |
| * [[meperidine]]
| |
| * [[Meridia]]
| |
| * [[methamphetamine]]
| |
| * [[methamphetamine extended release]]
| |
| * [[metrizamide]]
| |
| * [[Migranal]]
| |
| * [[mirtazapine]]
| |
| * [[Myelo-Kit]]
| |
| * [[naratriptan]]
| |
| * [[Nardil]]
| |
| * [[nefazodone]]
| |
| * [[Neocitran Thin Strips Cough]]
| |
| * [[Norpramin]]
| |
| * [[nortriptyline]]
| |
| * [[Novahistine DM]]
| |
| * [[Nucosef DM]]
| |
| * [[Obephen]]
| |
| * [[Obezine]]
| |
| * [[Oby-Cap]]
| |
| * [[Oby-Trim]]
| |
| * [[Omnipaque 140]]
| |
| * [[Omnipaque 180]]
| |
| * [[Omnipaque 180 Redi-Unit]]
| |
| * [[Omnipaque 210]]
| |
| * [[Omnipaque 240]]
| |
| * [[Omnipaque 240 Redi-Unit]]
| |
| * [[Omnipaque 300]]
| |
| * [[Omnipaque 350]]
| |
| * [[Omnipaque Flexipak]]
| |
| * [[Orlaam]]
| |
| * [[Pamelor]]
| |
| * [[Panshape M]]
| |
| * [[Parnate]]
| |
| * [[paroxetine]]
| |
| * [[paroxetine extended release]]
| |
| * [[paroxetine mesylate]]
| |
| * [[Paxil]]
| |
| * [[Paxil CR]]
| |
| * [[Pedia Relief]]
| |
| * [[Pediacare]]
| |
| * [[pentazocine]]
| |
| * [[Pertussin CS Childrens]]
| |
| * [[Pertussin DM]]
| |
| * [[Pertussin ES]]
| |
| * [[Pexeva]]
| |
| * [[Phendiet]]
| |
| * [[Phendiet-105]]
| |
| * [[phendimetrazine]]
| |
| * [[phendimetrazine extended release]]
| |
| * [[phenelzine]]
| |
| * [[Phentercot]]
| |
| * [[phentermine]]
| |
| * [[phentermine hydrochloride]]
| |
| * [[phentermine hydrochloride extended release]]
| |
| * [[phentermine resin extended release]]
| |
| * [[Phentride]]
| |
| * [[Phenyldrine]]
| |
| * [[phenylpropanolamine]]
| |
| * [[Plegine]]
| |
| * [[Pondimin]]
| |
| * [[PP-Cap]]
| |
| * [[Prelu-2]]
| |
| * [[Pristiq]]
| |
| * [[Pro-Fast HS]]
| |
| * [[Pro-Fast SA]]
| |
| * [[Pro-Fast SR]]
| |
| * [[procarbazine]]
| |
| * [[Propagest]]
| |
| * [[Propan]]
| |
| * [[propoxyphene]]
| |
| * [[propoxyphene hydrochloride]]
| |
| * [[propoxyphene napsylate]]
| |
| * [[protriptyline]]
| |
| * [[Prozac]]
| |
| * [[Prozac Weekly]]
| |
| * [[Prudoxin]]
| |
| * [[Rapiflux]]
| |
| * [[rasagiline]]
| |
| * [[Redux]]
| |
| * [[Relpax]]
| |
| * [[Remeron]]
| |
| * [[Remeron SolTab]]
| |
| * [[remifentanil]]
| |
| * [[Rhindecon]]
| |
| * [[rizatriptan]]
| |
| * [[Robafen Cough Liquidgels]]
| |
| * [[Robafen Pediatric Cough & Cold]]
| |
| * [[Robitussin Cough Calmers]]
| |
| * [[Robitussin CoughGels]]
| |
| * [[Robitussin Dry Cough]]
| |
| * [[Robitussin DX Cough Control]]
| |
| * [[Robitussin DX Cough Control Forte]]
| |
| * [[Robitussin DX Dry Cough Forte]]
| |
| * [[Robitussin Honey Cough]]
| |
| * [[Robitussin Junior Persistent Cough]]
| |
| * [[Robitussin Maximum Strength]]
| |
| * [[Robitussin Pediatric Cough Suppressant]]
| |
| * [[Robitussin Soft Pastilles]]
| |
| * [[Sanorex]]
| |
| * [[Sarafem]]
| |
| * [[Scot-Tussin Diabetic]]
| |
| * [[Scot-Tussin DM Cough Chasers]]
| |
| * [[selegiline]]
| |
| * [[Selgene]]
| |
| * [[sertraline]]
| |
| * [[Serzone]]
| |
| * [[sibutramine]]
| |
| * [[Silphen DM]]
| |
| * [[Sinequan]]
| |
| * [[sodium biphosphate]]
| |
| * [[sodium oxybate]]
| |
| * [[St. John's wort]]
| |
| * [[St. Joseph Cough Suppressant]]
| |
| * [[Statobex]]
| |
| * [[Strepsils Cough]]
| |
| * [[Strepsils Cough Relief]]
| |
| * [[Sublimaze]]
| |
| * [[Sucrets DM Cough]]
| |
| * [[Sufenta]]
| |
| * [[sufentanil]]
| |
| * [[sumatriptan]]
| |
| * [[sumatriptan nasal]]
| |
| * [[Surmontil]]
| |
| * [[T-Diet]]
| |
| * [[Talwin Lactate]]
| |
| * [[Tenuate]]
| |
| * [[Tenuate Dospan]]
| |
| * [[Teramine]]
| |
| * [[Teramine ER]]
| |
| * [[Terry White Chemists Tramadol]]
| |
| * [[Theraflu Thin Strips Cough]]
| |
| * [[Tofranil]]
| |
| * [[Tofranil-PM]]
| |
| * [[traMADOL]]
| |
| * [[traMADOL extended release]]
| |
| * [[Tramahexal]]
| |
| * [[Tramahexal SR]]
| |
| * [[Tramake]]
| |
| * [[Tramake Insts]]
| |
| * [[Tramal]]
| |
| * [[Tramal SR]]
| |
| * [[Tramedo]]
| |
| * [[tranylcypromine]]
| |
| * [[traZODONE]]
| |
| * [[Triaminic DM]]
| |
| * [[Triaminic Long Acting Cough]]
| |
| * [[Triaminic Long Acting Cough(obs)]]
| |
| * [[Triaminic Softchew]]
| |
| * [[Triaminic Thin Strips Cough]]
| |
| * [[Triaminic Thin Strips Nasal Congestion(obsolete)]]
| |
| * [[Triaminic Toddler Congestion Thin Strips(obsolete)]]
| |
| * [[trimipramine]]
| |
| * [[Tryptan]]
| |
| * [[tryptophan]]
| |
| * [[Tussin Pediatric]]
| |
| * [[Tussinol for Dry Coughs]]
| |
| * [[Tylenol Simply Cough]]
| |
| * [[Ultiva]]
| |
| * [[Ultram]]
| |
| * [[Ultram ER]]
| |
| * [[Vanatrip]]
| |
| * [[Vicks 44 Cough Medicine]]
| |
| * [[Vicks 44 Cough Relief]]
| |
| * [[Vicks Formula 44]]
| |
| * [[Vicks Formula 44 for Dry Coughs]]
| |
| * [[Vivactil]]
| |
| * [[Vyvanse]]
| |
| * [[Wellbutrin]]
| |
| * [[Wellbutrin SR]]
| |
| * [[Wellbutrin XL]]
| |
| * [[Westrim]]
| |
| * [[Westrim LA]]
| |
| * [[Xyrem]]
| |
| * [[Zamadol]]
| |
| * [[Zamadol 24hr]]
| |
| * [[Zamadol Melt]]
| |
| * [[Zamadol SR]]
| |
| * [[Zantryl]]
| |
| * [[Zelapar]]
| |
| * [[zolmitriptan]]
| |
| * [[Zoloft]]
| |
| * [[Zomig]]
| |
| * [[Zomig-ZMT]]
| |
| * [[Zonalon]]
| |
| * [[Zyban]]
| |
| * [[Zyban Advantage Pack]]
| |
| * [[Zydol]]
| |
| * [[Zydol SR]]
| |
| * [[Zydol XL]]
| |
| * [[Zyvox]]
| |
| {{refend}}
| |
|
| |
|
| ==Moderate Interactions==
| | '''As with all drugs, the potential for interaction by a variety of mechanisms is a possibility'''. |
| {{refbegin|3}}
| |
| * [[40 Winks]]
| |
| * [[Abbokinase]]
| |
| * [[Abbokinase Open-Cath]]
| |
| * [[abciximab]]
| |
| * [[Abilify]]
| |
| * [[Abilify Discmelt]]
| |
| * [[Accupril]]
| |
| * [[acebutolol]]
| |
| * [[Aceon]]
| |
| * [[acetylcarbromal]]
| |
| * [[Acetylsalicylic Acid]]
| |
| * [[Acova]]
| |
| * [[Actibine]]
| |
| * [[Activase]]
| |
| * [[Actron]]
| |
| * [[Acuprin 81]]
| |
| * [[Adgan]]
| |
| * [[Advil]]
| |
| * [[Advil Childrens]]
| |
| * [[Advil Junior Strength]]
| |
| * [[Advil Liquigel]]
| |
| * [[Advil Migraine]]
| |
| * [[Advil Pediatric]]
| |
| * [[Aflaxen]]
| |
| * [[Aggrastat]]
| |
| * [[Agrylin]]
| |
| * [[AHist]]
| |
| * [[Akineton HCl]]
| |
| * [[alcohol]]
| |
| * [[alcohol]]
| |
| * [[ethyl]]
| |
| * [[Aldactone]]
| |
| * [[Aler-Dryl]]
| |
| * [[Aler-Tab]]
| |
| * [[Aleve]]
| |
| * [[Aleve Caplet]]
| |
| * [[Aleve Easy Open Arthritis]]
| |
| * [[Aleve Gelcap]]
| |
| * [[alfuzosin]]
| |
| * [[alfuzosin extended release]]
| |
| * [[All Day Allergy]]
| |
| * [[Aller-Chlor]]
| |
| * [[Allergia-C]]
| |
| * [[Allerhist-1]]
| |
| * [[Allermax]]
| |
| * [[Alphagan]]
| |
| * [[Alphagan P]]
| |
| * [[alprazolam]]
| |
| * [[alprazolam extended release]]
| |
| * [[Altace]]
| |
| * [[Altaryl]]
| |
| * [[alteplase]]
| |
| * [[Ambien]]
| |
| * [[Ambien CR]]
| |
| * [[Amigesic]]
| |
| * [[amiloride]]
| |
| * [[amobarbital]]
| |
| * [[Amrix]]
| |
| * [[amyl nitrite]]
| |
| * [[Amytal Sodium]]
| |
| * [[Anaflex]]
| |
| * [[anagrelide]]
| |
| * [[Anaprox]]
| |
| * [[Anaprox-DS]]
| |
| * [[Anergan 50]]
| |
| * [[Angiomax]]
| |
| * [[anisindione]]
| |
| * [[anistreplase]]
| |
| * [[Ansaid]]
| |
| * [[Antiflex]]
| |
| * [[Antinaus 50]]
| |
| * [[antithrombin III]]
| |
| * [[Anturane]]
| |
| * [[Aphrodyne]]
| |
| * [[APO-Go]]
| |
| * [[APO-Go Pen]]
| |
| * [[Apokyn]]
| |
| * [[apomorphine]]
| |
| * [[apraclonidine ophthalmic]]
| |
| * [[Apresoline]]
| |
| * [[Aquachloral Supprettes]]
| |
| * [[Aquacot]]
| |
| * [[Aquatensen]]
| |
| * [[Aquazide H]]
| |
| * [[ardeparin]]
| |
| * [[Arfonad]]
| |
| * [[argatroban]]
| |
| * [[Argesic-SA]]
| |
| * [[aripiprazole]]
| |
| * [[Arixtra]]
| |
| * [[Arixtra 10 mg/dose]]
| |
| * [[Arixtra 5 mg/dose]]
| |
| * [[Arixtra 7.5 mg/dose]]
| |
| * [[Artane]]
| |
| * [[Arthritis Pain]]
| |
| * [[Arthropan]]
| |
| * [[ASA]]
| |
| * [[Ascriptin Enteric]]
| |
| * [[Aspergum Cherry]]
| |
| * [[Aspergum Orginal]]
| |
| * [[Aspir-Low]]
| |
| * [[aspirin]]
| |
| * [[aspirin extended release]]
| |
| * [[Aspirin Lite Coat]]
| |
| * [[Aspirin Litecoat]]
| |
| * [[Aspirin Low Strength]]
| |
| * [[Aspirtab]]
| |
| * [[Astramorph PF]]
| |
| * [[Atacand]]
| |
| * [[Atarax]]
| |
| * [[atenolol]]
| |
| * [[Ativan]]
| |
| * [[Atnativ]]
| |
| * [[Avapro]]
| |
| * [[Avinza]]
| |
| * [[azatadine]]
| |
| * [[B-Vex]]
| |
| * [[baclofen]]
| |
| * [[Banaril]]
| |
| * [[Banflex]]
| |
| * [[Banophen]]
| |
| * [[Bayer Aspirin]]
| |
| * [[Bayer Aspirin Regimen]]
| |
| * [[Bayer Aspirin Sugar Free]]
| |
| * [[Bayer Aspirin with Calcium]]
| |
| * [[Bayer Childrens Aspirin]]
| |
| * [[Bayer Low Strength]]
| |
| * [[Bayer Plus]]
| |
| * [[Bayer Select Backache Pain Formula]]
| |
| * [[Beldin]]
| |
| * [[Belix]]
| |
| * [[Ben-Tann]]
| |
| * [[Benadryl]]
| |
| * [[Benadryl Allergy]]
| |
| * [[Benadryl Child Dye Free]]
| |
| * [[Benadryl Childrens Allergy Fastmelt]]
| |
| * [[Benadryl DF]]
| |
| * [[Benadryl Dye Free Allergy]]
| |
| * [[Benadryl Ultratab]]
| |
| * [[Benahist-10]]
| |
| * [[Benahist-50]]
| |
| * [[benazepril]]
| |
| * [[bendroflumethiazide]]
| |
| * [[Benicar]]
| |
| * [[Benoject-50]]
| |
| * [[Benzacot]]
| |
| * [[benzthiazide]]
| |
| * [[benztropine]]
| |
| * [[Betapace]]
| |
| * [[Betapace AF]]
| |
| * [[Betapace AF(obsolete)]]
| |
| * [[betaxolol]]
| |
| * [[Bexxar Dosimetric]]
| |
| * [[Bexxar I 131 Dosimetric]]
| |
| * [[Bexxar I 131 Therapeutic]]
| |
| * [[BexxarTherapeutic]]
| |
| * [[Bidhist]]
| |
| * [[biperiden]]
| |
| * [[Bismarex]]
| |
| * [[Bismatrol]]
| |
| * [[Bismatrol Maximum Strength]]
| |
| * [[bismuth subsalicylate]]
| |
| * [[bisoprolol]]
| |
| * [[bivalirudin]]
| |
| * [[Blocadren]]
| |
| * [[Brevibloc]]
| |
| * [[brimonidine ophthalmic]]
| |
| * [[Bromaphen]]
| |
| * [[bromfenac]]
| |
| * [[bromocriptine]]
| |
| * [[bromodiphenhydramine]]
| |
| * [[brompheniramine]]
| |
| * [[brompheniramine extended release]]
| |
| * [[BroveX]]
| |
| * [[BroveX CT]]
| |
| * [[Buffered Aspirin]]
| |
| * [[Bufferin]]
| |
| * [[Bufferin Arthritis Strength]]
| |
| * [[Bufferin Extra Strength]]
| |
| * [[Buffex]]
| |
| * [[bumetanide]]
| |
| * [[Bumex]]
| |
| * [[Buprenex]]
| |
| * [[buprenorphine]]
| |
| * [[Busodium]]
| |
| * [[butabarbital]]
| |
| * [[butalbital]]
| |
| * [[Butisol Sodium]]
| |
| * [[butorphanol]]
| |
| * [[butorphanol nasal]]
| |
| * [[Bydramine]]
| |
| * [[C.P.M.]]
| |
| * [[Calm-Aid]]
| |
| * [[candesartan]]
| |
| * [[Capoten]]
| |
| * [[captopril]]
| |
| * [[Carbacot]]
| |
| * [[carbamazepine]]
| |
| * [[carbamazepine extended release]]
| |
| * [[Carbatrol]]
| |
| * [[carbetapentane]]
| |
| * [[carbinoxamine]]
| |
| * [[carbinoxamine extended release]]
| |
| * [[Carbinoxamine PD]]
| |
| * [[Carboxine]]
| |
| * [[Cardizem]]
| |
| * [[Cardizem CD]]
| |
| * [[Cardizem LA]]
| |
| * [[Cardizem Monovial]]
| |
| * [[Cardizem SR]]
| |
| * [[Cardura]]
| |
| * [[Cardura XL]]
| |
| * [[Carduran]]
| |
| * [[carisoprodol]]
| |
| * [[Carozide]]
| |
| * [[carteolol]]
| |
| * [[Cartia XT]]
| |
| * [[Cartrol]]
| |
| * [[Cascor]]
| |
| * [[Cataflam]]
| |
| * [[Catapres]]
| |
| * [[Catapres-TTS-1]]
| |
| * [[Catapres-TTS-2]]
| |
| * [[Catapres-TTS-3]]
| |
| * [[Cathflo Activase]]
| |
| * [[Celebrex]]
| |
| * [[celecoxib]]
| |
| * [[Celontin]]
| |
| * [[Cerebyx]]
| |
| * [[Cesamet]]
| |
| * [[cetirizine]]
| |
| * [[cevimeline]]
| |
| * [[Childrens Ibuprofen Berry]]
| |
| * [[Childrens Kaopectate]]
| |
| * [[Chlo-Amine]]
| |
| * [[Chlor-Al Rel]]
| |
| * [[Chlor-Mal]]
| |
| * [[Chlor-Phen]]
| |
| * [[Chlor-Phenit]]
| |
| * [[Chlor-Trimeton]]
| |
| * [[Chlor-Trimeton Allergy SR]]
| |
| * [[chloral hydrate]]
| |
| * [[chlordiazepoxide]]
| |
| * [[chlormezanone]]
| |
| * [[chlorothiazide]]
| |
| * [[Chlorphen]]
| |
| * [[chlorphenesin]]
| |
| * [[chlorpheniramine]]
| |
| * [[Chlorpheniramine (Allergy)]]
| |
| * [[chlorpheniramine 24 hour extended release]]
| |
| * [[chlorpheniramine extended release]]
| |
| * [[chlorproMAZINE]]
| |
| * [[chlorproMAZINE extended release]]
| |
| * [[ChlorTan]]
| |
| * [[chlorthalidone]]
| |
| * [[chlorzoxazone]]
| |
| * [[choline salicylate]]
| |
| * [[cilostazol]]
| |
| * [[cinacalcet]]
| |
| * [[clemastine]]
| |
| * [[Clexane]]
| |
| * [[Clexane Forte]]
| |
| * [[Clinoril]]
| |
| * [[clonazepam]]
| |
| * [[clonidine]]
| |
| * [[clonidine topical]]
| |
| * [[clopidogrel]]
| |
| * [[Clopine]]
| |
| * [[clorazepate]]
| |
| * [[clorazepate extended release]]
| |
| * [[clozapine]]
| |
| * [[Clozapine Synthon]]
| |
| * [[Clozaril]]
| |
| * [[codeine]]
| |
| * [[codeine phosphate]]
| |
| * [[codeine sulfate]]
| |
| * [[Codimal A]]
| |
| * [[Cogentin]]
| |
| * [[Compazine]]
| |
| * [[Compazine Spansule]]
| |
| * [[Compoz Nighttime Sleep Aid]]
| |
| * [[Compro]]
| |
| * [[Comtan]]
| |
| * [[Contac 12 Hour Allergy]]
| |
| * [[Cophene B]]
| |
| * [[Cordron NR]]
| |
| * [[Corgard]]
| |
| * [[Corlopam]]
| |
| * [[Coumadin]]
| |
| * [[Cozaar]]
| |
| * [[Crixivan]]
| |
| * [[cyclobenzaprine]]
| |
| * [[cyclobenzaprine extended release]]
| |
| * [[cyproheptadine]]
| |
| * [[Dailyhist-1]]
| |
| * [[Dalgan]]
| |
| * [[Dalmane]]
| |
| * [[dalteparin]]
| |
| * [[danaparoid]]
| |
| * [[Dantrium]]
| |
| * [[Dantrium Intravenous]]
| |
| * [[dantrolene]]
| |
| * [[dasatinib]]
| |
| * [[Daypro]]
| |
| * [[Dayto-Himbin]]
| |
| * [[Dazidox]]
| |
| * [[Dehydrated Alcohol]]
| |
| * [[Demadex]]
| |
| * [[Demadex I.V.]]
| |
| * [[Denzapine]]
| |
| * [[Depacon]]
| |
| * [[Depakene]]
| |
| * [[Depakote]]
| |
| * [[Depakote ER]]
| |
| * [[Depakote Sprinkles]]
| |
| * [[DepoDur]]
| |
| * [[Deponit]]
| |
| * [[deserpidine]]
| |
| * [[desirudin]]
| |
| * [[dexbrompheniramine]]
| |
| * [[dexmedetomidine]]
| |
| * [[dezocine]]
| |
| * [[Di-Phen]]
| |
| * [[Diaqua]]
| |
| * [[Diaqua-2]]
| |
| * [[Diastat]]
| |
| * [[Diastat AcuDial]]
| |
| * [[Diastat Pediatric]]
| |
| * [[diazepam]]
| |
| * [[diazoxide]]
| |
| * [[Dibenzyline]]
| |
| * [[diclofenac]]
| |
| * [[diclofenac potassium]]
| |
| * [[diclofenac sodium]]
| |
| * [[diclofenac sodium extended release]]
| |
| * [[dicumarol]]
| |
| * [[diflunisal]]
| |
| * [[dihydrocodeine]]
| |
| * [[Dilacor XR]]
| |
| * [[Dilantin]]
| |
| * [[Dilantin Infatabs]]
| |
| * [[Dilantin Kapseals]]
| |
| * [[Dilantin-125]]
| |
| * [[Dilatrate-SR]]
| |
| * [[Dilaudid]]
| |
| * [[Dilaudid-5]]
| |
| * [[Dilaudid-HP]]
| |
| * [[Diltia XT]]
| |
| * [[diltiazem]]
| |
| * [[diltiazem 24 hour extended release]]
| |
| * [[diltiazem extended release]]
| |
| * [[Diltiazem Hydrochloride CD]]
| |
| * [[Diltiazem Hydrochloride SR]]
| |
| * [[Diltiazem Hydrochloride XR]]
| |
| * [[Diltiazem Hydrochloride XT]]
| |
| * [[Dimetane]]
| |
| * [[Dimetane Extentab]]
| |
| * [[Dimetapp Allergy]]
| |
| * [[Dimetapp Allergy Liquigel]]
| |
| * [[Diovan]]
| |
| * [[Diphedryl]]
| |
| * [[Diphen]]
| |
| * [[Diphen AF]]
| |
| * [[Diphen Cough]]
| |
| * [[Diphenadryl]]
| |
| * [[Diphendryl]]
| |
| * [[Diphenhist]]
| |
| * [[diphenhydrAMINE]]
| |
| * [[diphenhydrAMINE citrate]]
| |
| * [[diphenhydrAMINE tannate]]
| |
| * [[Diphenmax]]
| |
| * [[Diphenydramine Quick Melt]]
| |
| * [[Diphenyl]]
| |
| * [[Diphenylin]]
| |
| * [[Diprivan]]
| |
| * [[dipyridamole]]
| |
| * [[Disalcid]]
| |
| * [[Diskets]]
| |
| * [[Diucardin]]
| |
| * [[Diurese]]
| |
| * [[Diuril]]
| |
| * [[Diuril Sodium]]
| |
| * [[divalproex sodium]]
| |
| * [[divalproex sodium extended release]]
| |
| * [[Dizac]]
| |
| * [[Doans Pills]]
| |
| * [[Doans Pills Extra Strength]]
| |
| * [[Dolobid]]
| |
| * [[Dolophine]]
| |
| * [[Doloral]]
| |
| * [[Doloral Sirop]]
| |
| * [[Doral]]
| |
| * [[Doxadura]]
| |
| * [[doxazosin]]
| |
| * [[doxazosin extended release]]
| |
| * [[doxylamine]]
| |
| * [[DPH]]
| |
| * [[dronabinol]]
| |
| * [[droperidol]]
| |
| * [[drotrecogin]]
| |
| * [[drotrecogin alfa]]
| |
| * [[Duraclon]]
| |
| * [[DurAct]]
| |
| * [[Duramorph PF]]
| |
| * [[Dyrenium]]
| |
| * [[Dytan]]
| |
| * [[Dytuss]]
| |
| * [[Easprin]]
| |
| * [[EC-Naprosyn]]
| |
| * [[Ecotrin]]
| |
| * [[Ecotrin Adult Low Strength]]
| |
| * [[Ecotrin Maximum Strength]]
| |
| * [[Ed Chlor-Tan]]
| |
| * [[Ed ChlorPed]]
| |
| * [[Edecrin]]
| |
| * [[Edecrin Sodium]]
| |
| * [[Efidac-24 Chlorpheniramine]]
| |
| * [[Empirin]]
| |
| * [[enalapril]]
| |
| * [[enalaprilat]]
| |
| * [[Endocodone]]
| |
| * [[Enduron]]
| |
| * [[enoxaparin]]
| |
| * [[entacapone]]
| |
| * [[Entaprin]]
| |
| * [[Entercote]]
| |
| * [[Epitol]]
| |
| * [[eplerenone]]
| |
| * [[epoprostenol]]
| |
| * [[eprosartan]]
| |
| * [[eptifibatide]]
| |
| * [[Equanil]]
| |
| * [[Equetro]]
| |
| * [[Erex]]
| |
| * [[Esidrix]]
| |
| * [[esmolol]]
| |
| * [[estazolam]]
| |
| * [[eszopiclone]]
| |
| * [[ETH-Oxydose]]
| |
| * [[ethacrynic acid]]
| |
| * [[ethanol]]
| |
| * [[ethosuximide]]
| |
| * [[ethotoin]]
| |
| * [[Ethyl Alcohol]]
| |
| * [[etodolac]]
| |
| * [[etodolac extended release]]
| |
| * [[Evoxac]]
| |
| * [[Exna]]
| |
| * [[Extra Strength Bayer]]
| |
| * [[Eze D.S.]]
| |
| * [[Ezide]]
| |
| * [[Fasprin]]
| |
| * [[FazaClo]]
| |
| * [[felbamate]]
| |
| * [[Felbatol]]
| |
| * [[Feldene]]
| |
| * [[fenoldopam]]
| |
| * [[fenoprofen]]
| |
| * [[Fexmid]]
| |
| * [[flavoxate]]
| |
| * [[Flexeril]]
| |
| * [[Flexoject]]
| |
| * [[Flexon]]
| |
| * [[Flolan]]
| |
| * [[fluphenazine]]
| |
| * [[fluphenazine decanoate]]
| |
| * [[fluphenazine enanthate]]
| |
| * [[fluphenazine hydrochloride]]
| |
| * [[flurazepam]]
| |
| * [[flurbiprofen]]
| |
| * [[fondaparinux]]
| |
| * [[fosinopril]]
| |
| * [[fosphenytoin]]
| |
| * [[Fragmin]]
| |
| * [[furosemide]]
| |
| * [[gabapentin]]
| |
| * [[Gabarone]]
| |
| * [[Gabitril]]
| |
| * [[Genacote]]
| |
| * [[Genahist]]
| |
| * [[Gennin-FC]]
| |
| * [[Genpril]]
| |
| * [[Genprin]]
| |
| * [[Geodon]]
| |
| * [[Gleevec]]
| |
| * [[guanabenz]]
| |
| * [[guanadrel]]
| |
| * [[guanfacine]]
| |
| * [[halazepam]]
| |
| * [[Halcion]]
| |
| * [[Halfprin]]
| |
| * [[Haltran]]
| |
| * [[Harmonyl]]
| |
| * [[HCTZ]]
| |
| * [[Hep-Lock]]
| |
| * [[Hep-Pak]]
| |
| * [[Hep-Pak CVC]]
| |
| * [[heparin]]
| |
| * [[Heparin Lock Flush]]
| |
| * [[Histaject]]
| |
| * [[Histex CT]]
| |
| * [[Histex I/E]]
| |
| * [[Histex PD]]
| |
| * [[Histex Pd 12]]
| |
| * [[hydrALAZINE]]
| |
| * [[Hydramine]]
| |
| * [[Hydramine Compound]]
| |
| * [[Hydramine Cough Syrup]]
| |
| * [[Hydro Par]]
| |
| * [[hydrochlorothiazide]]
| |
| * [[hydrocodone]]
| |
| * [[HydroDIURIL]]
| |
| * [[hydroflumethiazide]]
| |
| * [[Hydromorph Contin]]
| |
| * [[hydromorphone]]
| |
| * [[hydromorphone extended release]]
| |
| * [[Hydrostat IR]]
| |
| * [[hydrOXYzine]]
| |
| * [[hydrOXYzine hydrochloride]]
| |
| * [[hydrOXYzine pamoate]]
| |
| * [[Hygroton]]
| |
| * [[Hylorel]]
| |
| * [[Hyperstat]]
| |
| * [[Hyrexin]]
| |
| * [[Hytrin]]
| |
| * [[Hyzine]]
| |
| * [[ibritumomab]]
| |
| * [[Ibu]]
| |
| * [[IBU-200]]
| |
| * [[Ibu-4]]
| |
| * [[Ibu-6]]
| |
| * [[Ibu-8]]
| |
| * [[Ibu-Tab]]
| |
| * [[ibuprofen]]
| |
| * [[Ibuprofen PMR]]
| |
| * [[iloprost]]
| |
| * [[imatinib]]
| |
| * [[Imdur]]
| |
| * [[In-111 Zevalin]]
| |
| * [[Inapsine]]
| |
| * [[indapamide]]
| |
| * [[Inderal]]
| |
| * [[Inderal LA]]
| |
| * [[indinavir]]
| |
| * [[Indocin]]
| |
| * [[Indocin SR]]
| |
| * [[indomethacin]]
| |
| * [[indomethacin extended release]]
| |
| * [[Infumorph]]
| |
| * [[Innohep]]
| |
| * [[InnoPran XL]]
| |
| * [[Inspra]]
| |
| * [[Integrilin]]
| |
| * [[Invega]]
| |
| * [[iodine I 131 tositumomab]]
| |
| * [[Iopidine]]
| |
| * [[Iprivask]]
| |
| * [[irbesartan]]
| |
| * [[ISDN]]
| |
| * [[ISMO]]
| |
| * [[Isochron]]
| |
| * [[Isordil]]
| |
| * [[Isordil Tembids]]
| |
| * [[Isordil Titradose]]
| |
| * [[isosorbide dinitrate]]
| |
| * [[isosorbide dinitrate extended release]]
| |
| * [[isosorbide mononitrate]]
| |
| * [[isosorbide mononitrate extended release]]
| |
| * [[J-Tan]]
| |
| * [[J-Tan PD]]
| |
| * [[Jantoven]]
| |
| * [[K-Pek]]
| |
| * [[Kabikinase]]
| |
| * [[Kadian]]
| |
| * [[Kao-Tin Bismuth Subsalicylate Formula]]
| |
| * [[Kaopectate]]
| |
| * [[Kaopectate Anti-Diarrheal Upset Stomach Reliever]]
| |
| * [[Kaopectate Extra Strength]]
| |
| * [[Kapectolin (New Formula)]]
| |
| * [[Kemadrin]]
| |
| * [[Keppra]]
| |
| * [[Kerlone]]
| |
| * [[Ketalar]]
| |
| * [[ketamine]]
| |
| * [[ketoprofen]]
| |
| * [[ketoprofen extended release]]
| |
| * [[ketorolac]]
| |
| * [[Kinlytic]]
| |
| * [[Klonopin]]
| |
| * [[Klonopin Wafer]]
| |
| * [[labetalol]]
| |
| * [[Lamictal]]
| |
| * [[Lamictal Blue]]
| |
| * [[Lamictal CD]]
| |
| * [[Lamictal Green]]
| |
| * [[Lamictal Orange]]
| |
| * [[Lamisil]]
| |
| * [[lamotrigine]]
| |
| * [[Largon]]
| |
| * [[Lasix]]
| |
| * [[Leader Naproxen Sodium]]
| |
| * [[lepirudin]]
| |
| * [[Levatol]]
| |
| * [[levetiracetam]]
| |
| * [[Levo-Dromoran]]
| |
| * [[levocetirizine]]
| |
| * [[levorphanol]]
| |
| * [[LEVRIX]]
| |
| * [[Librium]]
| |
| * [[lindane topical]]
| |
| * [[Lioresal]]
| |
| * [[Lioresal Intrathecal]]
| |
| * [[lisinopril]]
| |
| * [[Litecoat Aspirin]]
| |
| * [[Lo-Aqua]]
| |
| * [[Lodine]]
| |
| * [[Lodine XL]]
| |
| * [[Lodrane 12 Hour]]
| |
| * [[Lodrane 24]]
| |
| * [[Lodrane XR]]
| |
| * [[Loniten]]
| |
| * [[Lopressor]]
| |
| * [[Loqua]]
| |
| * [[lorazepam]]
| |
| * [[losartan]]
| |
| * [[Lotensin]]
| |
| * [[Lovenox]]
| |
| * [[Lovenox HP]]
| |
| * [[Low Dose ASA]]
| |
| * [[loxapine]]
| |
| * [[Loxitane]]
| |
| * [[Loxitane C]]
| |
| * [[Loxitane IM]]
| |
| * [[Lozol]]
| |
| * [[Luminal]]
| |
| * [[Lunesta]]
| |
| * [[Lyrica]]
| |
| * [[M-Eslon]]
| |
| * [[M-Oxy]]
| |
| * [[M. O. S.]]
| |
| * [[Maalox Total Stomach Relief]]
| |
| * [[Magan]]
| |
| * [[magnesium salicylate]]
| |
| * [[Maolate]]
| |
| * [[Marinol]]
| |
| * [[Marthritic]]
| |
| * [[Mavik]]
| |
| * [[Maximum Strength Stress]]
| |
| * [[MB-TAB]]
| |
| * [[Mebaral]]
| |
| * [[meclofenamate]]
| |
| * [[Meclomen]]
| |
| * [[Mederek]]
| |
| * [[mefenamic acid]]
| |
| * [[meloxicam]]
| |
| * [[Menadol]]
| |
| * [[mephenytoin]]
| |
| * [[mephobarbital]]
| |
| * [[meprobamate]]
| |
| * [[Mesantoin]]
| |
| * [[mesoridazine]]
| |
| * [[Metahydrin]]
| |
| * [[metaxalone]]
| |
| * [[methadone]]
| |
| * [[Methadose]]
| |
| * [[methocarbamol]]
| |
| * [[methsuximide]]
| |
| * [[methyclothiazide]]
| |
| * [[metoclopramide]]
| |
| * [[metolazone]]
| |
| * [[metoprolol]]
| |
| * [[metoprolol extended release]]
| |
| * [[metoprolol succinate]]
| |
| * [[Metoprolol Succinate ER]]
| |
| * [[metoprolol tartrate]]
| |
| * [[mibefradil]]
| |
| * [[Micardis]]
| |
| * [[Microzide]]
| |
| * [[Midamor]]
| |
| * [[midazolam]]
| |
| * [[Midol Extended Relief]]
| |
| * [[Midol IB]]
| |
| * [[Midol Maximum Strength Cramp Formula]]
| |
| * [[Milontin]]
| |
| * [[Miltown]]
| |
| * [[Minipress]]
| |
| * [[Minitabs]]
| |
| * [[Minitran]]
| |
| * [[minoxidil]]
| |
| * [[Mio-Rel]]
| |
| * [[Miradon]]
| |
| * [[Mirapex]]
| |
| * [[Mithracin]]
| |
| * [[Mitran]]
| |
| * [[Moban]]
| |
| * [[Mobic]]
| |
| * [[Mobidin]]
| |
| * [[moexipril]]
| |
| * [[molindone]]
| |
| * [[Mono-Gesic]]
| |
| * [[Monoket]]
| |
| * [[Monopril]]
| |
| * [[morphine]]
| |
| * [[morphine 24 hour extended release]]
| |
| * [[morphine extended release]]
| |
| * [[Morphine IR]]
| |
| * [[morphine liposomal]]
| |
| * [[Morphine LP Epidural]]
| |
| * [[morphine preservative-free]]
| |
| * [[Morphine Rapi-Ject]]
| |
| * [[Morphitec]]
| |
| * [[Motrin]]
| |
| * [[Motrin Childrens]]
| |
| * [[Motrin IB]]
| |
| * [[Motrin Infant Drops]]
| |
| * [[Motrin Junior Strength]]
| |
| * [[Motrin Migraine Pain]]
| |
| * [[MS]]
| |
| * [[MS Contin]]
| |
| * [[MS/S]]
| |
| * [[MSIR]]
| |
| * [[MST]]
| |
| * [[Mykrox]]
| |
| * [[Myolin]]
| |
| * [[Mysoline]]
| |
| * [[nabilone]]
| |
| * [[nabumetone]]
| |
| * [[nadolol]]
| |
| * [[nalbuphine]]
| |
| * [[Nalfon]]
| |
| * [[Naprelan '375']]
| |
| * [[Naprelan '500']]
| |
| * [[Naprosyn]]
| |
| * [[naproxen]]
| |
| * [[naproxen sodium]]
| |
| * [[Naproxen Sodium DS]]
| |
| * [[naproxen sodium extended release]]
| |
| * [[Naqua]]
| |
| * [[Nasahist B]]
| |
| * [[Naturetin-10]]
| |
| * [[Naturetin-5]]
| |
| * [[Navane]]
| |
| * [[ND-Stat]]
| |
| * [[Nembutal]]
| |
| * [[Nembutal Sodium]]
| |
| * [[NeoProfen]]
| |
| * [[Nervine]]
| |
| * [[Neupro]]
| |
| * [[Neurontin]]
| |
| * [[Nightime Sleepaid]]
| |
| * [[nilotinib]]
| |
| * [[Niravam]]
| |
| * [[Nitrek]]
| |
| * [[Nitro TD Patch-A]]
| |
| * [[Nitro-Bid]]
| |
| * [[Nitro-Bid IV]]
| |
| * [[Nitro-Dur]]
| |
| * [[Nitro-Par]]
| |
| * [[Nitro-Time]]
| |
| * [[Nitrocot]]
| |
| * [[Nitrodisc]]
| |
| * [[Nitrogard]]
| |
| * [[nitroglycerin]]
| |
| * [[Nitroglyn E-R]]
| |
| * [[Nitrol]]
| |
| * [[Nitrol Appli-Kit]]
| |
| * [[Nitrolingual]]
| |
| * [[Nitrong]]
| |
| * [[Nitropress]]
| |
| * [[nitroprusside]]
| |
| * [[Nitroquick]]
| |
| * [[Nitrostat]]
| |
| * [[Norflex]]
| |
| * [[Norflex Injectable]]
| |
| * [[Normiflo]]
| |
| * [[Normodyne]]
| |
| * [[Norwich Aspirin]]
| |
| * [[NTG]]
| |
| * [[Nu-Med]]
| |
| * [[Nubain]]
| |
| * [[Numorphan HCl]]
| |
| * [[Nuprin]]
| |
| * [[Nuprin Backache Caplet]]
| |
| * [[Nytol Caplet]]
| |
| * [[Nytol Maximum Strength]]
| |
| * [[olanzapine]]
| |
| * [[olmesartan]]
| |
| * [[olopatadine nasal]]
| |
| * [[OMS]]
| |
| * [[Opana]]
| |
| * [[Opana ER]]
| |
| * [[opium]]
| |
| * [[Opium Deodorized]]
| |
| * [[Optimine]]
| |
| * [[Oramorph SR]]
| |
| * [[Orap]]
| |
| * [[Oretic]]
| |
| * [[Orfro]]
| |
| * [[Orgaran]]
| |
| * [[Ormazine]]
| |
| * [[orphenadrine]]
| |
| * [[orphenadrine extended release]]
| |
| * [[Orphenate]]
| |
| * [[Orudis]]
| |
| * [[Orudis KT]]
| |
| * [[Oruvail]]
| |
| * [[oxaprozin]]
| |
| * [[oxazepam]]
| |
| * [[oxycodone]]
| |
| * [[oxycodone extended release]]
| |
| * [[OxyContin]]
| |
| * [[Oxyfast]]
| |
| * [[OxyIR]]
| |
| * [[oxymorphone]]
| |
| * [[oxymorphone extended release]]
| |
| * [[P-Tann]]
| |
| * [[P-Tex]]
| |
| * [[Palgic]]
| |
| * [[paliperidone]]
| |
| * [[Palladone]]
| |
| * [[Palladone SR]]
| |
| * [[Paradione]]
| |
| * [[Paraflex]]
| |
| * [[Parafon Forte DSC]]
| |
| * [[Paral]]
| |
| * [[paraldehyde]]
| |
| * [[paramethadione]]
| |
| * [[Pardryl]]
| |
| * [[Paregoric]]
| |
| * [[Parlodel]]
| |
| * [[Patanase]]
| |
| * [[Paxarel]]
| |
| * [[PBZ]]
| |
| * [[PBZ-SR]]
| |
| * [[Pediacare Fever]]
| |
| * [[PediaTan]]
| |
| * [[Pediatex]]
| |
| * [[Pediatex 12]]
| |
| * [[Pediox]]
| |
| * [[Pediox-S]]
| |
| * [[Peganone]]
| |
| * [[penbutolol]]
| |
| * [[Pentazine]]
| |
| * [[pentobarbital]]
| |
| * [[Peptic Relief]]
| |
| * [[Pepto-Bismol]]
| |
| * [[Pepto-Bismol Maximum Strength]]
| |
| * [[Percolone]]
| |
| * [[pergolide]]
| |
| * [[Periactin]]
| |
| * [[perindopril]]
| |
| * [[Permax]]
| |
| * [[Permitil]]
| |
| * [[perphenazine]]
| |
| * [[Persantine]]
| |
| * [[Persantine IV]]
| |
| * [[phenacemide]]
| |
| * [[Phenadoz]]
| |
| * [[Phenazine 50]]
| |
| * [[Phenergan]]
| |
| * [[Phenergan Fortis]]
| |
| * [[phenobarbital]]
| |
| * [[Phenoject-50]]
| |
| * [[phenoxybenzamine]]
| |
| * [[phensuximide]]
| |
| * [[phentolamine]]
| |
| * [[Phenurone]]
| |
| * [[phenyl salicylate]]
| |
| * [[phenylbutazone]]
| |
| * [[Phenytek]]
| |
| * [[phenytoin]]
| |
| * [[phenytoin extended release]]
| |
| * [[Phenytoin Sodium]]
| |
| * [[Prompt]]
| |
| * [[pimozide]]
| |
| * [[pindolol]]
| |
| * [[Pink Bismuth]]
| |
| * [[piroxicam]]
| |
| * [[Plavix]]
| |
| * [[Pletal]]
| |
| * [[plicamycin]]
| |
| * [[polythiazide]]
| |
| * [[Ponstel]]
| |
| * [[Posicor]]
| |
| * [[pramipexole]]
| |
| * [[prazosin]]
| |
| * [[Precedex]]
| |
| * [[pregabalin]]
| |
| * [[Prialt]]
| |
| * [[primidone]]
| |
| * [[Prinivil]]
| |
| * [[Pro-Med]]
| |
| * [[prochlorperazine]]
| |
| * [[prochlorperazine extended release]]
| |
| * [[Procot]]
| |
| * [[procyclidine]]
| |
| * [[Proglycem]]
| |
| * [[Prolixin]]
| |
| * [[Prolixin Decanoate]]
| |
| * [[Prolixin Enanthate]]
| |
| * [[Promacot]]
| |
| * [[promazine]]
| |
| * [[promethazine]]
| |
| * [[Promethegan]]
| |
| * [[Prop-A-Tane]]
| |
| * [[propiomazine]]
| |
| * [[propofol]]
| |
| * [[propranolol]]
| |
| * [[propranolol extended release]]
| |
| * [[Prorex]]
| |
| * [[Prosom]]
| |
| * [[prostacyclin]]
| |
| * [[Q-Dryl]]
| |
| * [[Q-Dryl A/F]]
| |
| * [[Q-Profen]]
| |
| * [[QDALL AR]]
| |
| * [[quazepam]]
| |
| * [[Quenalin]]
| |
| * [[quetiapine]]
| |
| * [[quetiapine extended release]]
| |
| * [[quinapril]]
| |
| * [[ramipril]]
| |
| * [[Ranexa]]
| |
| * [[ranolazine]]
| |
| * [[Rauwolfemms]]
| |
| * [[Rauwolfia 1X]]
| |
| * [[rauwolfia serpentina]]
| |
| * [[Refludan]]
| |
| * [[Reglan]]
| |
| * [[Relafen]]
| |
| * [[Relaxazone]]
| |
| * [[Remodulin]]
| |
| * [[Remular]]
| |
| * [[Remular-S]]
| |
| * [[Renese]]
| |
| * [[Reopro]]
| |
| * [[Repreve]]
| |
| * [[Requip]]
| |
| * [[ReQuip Follow on Pack]]
| |
| * [[Requip Starter Kit]]
| |
| * [[ReQuip Starter Pack]]
| |
| * [[Rescudose]]
| |
| * [[reserpine]]
| |
| * [[Restoril]]
| |
| * [[Retavase]]
| |
| * [[reteplase]]
| |
| * [[Rexolate]]
| |
| * [[Rezine]]
| |
| * [[Rezulin]]
| |
| * [[Ridramin]]
| |
| * [[Risperdal]]
| |
| * [[Risperdal Consta]]
| |
| * [[Risperdal M-Tab]]
| |
| * [[risperidone]]
| |
| * [[RMS]]
| |
| * [[Robaxin]]
| |
| * [[Robaxin-750]]
| |
| * [[Rohist]]
| |
| * [[ropinirole]]
| |
| * [[rotigotine]]
| |
| * [[Roxanol]]
| |
| * [[Roxanol 100]]
| |
| * [[Roxanol-T]]
| |
| * [[Roxicodone]]
| |
| * [[Roxicodone Intensol]]
| |
| * [[Rufen]]
| |
| * [[Saleto-200]]
| |
| * [[Saleto-400]]
| |
| * [[Saleto-600]]
| |
| * [[Saleto-800]]
| |
| * [[Salflex]]
| |
| * [[salsalate]]
| |
| * [[Salsitab]]
| |
| * [[Saluron]]
| |
| * [[Scot-Tussin Allergy Relief Formula]]
| |
| * [[secobarbital]]
| |
| * [[Seconal Sodium]]
| |
| * [[Sectral]]
| |
| * [[Sensipar]]
| |
| * [[Serax]]
| |
| * [[Serentil]]
| |
| * [[Seroquel]]
| |
| * [[Seroquel XR]]
| |
| * [[Siladryl]]
| |
| * [[Siladryl DAS]]
| |
| * [[Siladyl SA]]
| |
| * [[Silphen Cough]]
| |
| * [[Siltane]]
| |
| * [[Simply Sleep]]
| |
| * [[Skelaxin]]
| |
| * [[Skelex]]
| |
| * [[Sleep Tab II]]
| |
| * [[Sleep Tabs]]
| |
| * [[Sleep-ettes]]
| |
| * [[Sleep-Eze-3]]
| |
| * [[Sleepinal]]
| |
| * [[Sloprin]]
| |
| * [[sodium nitroprusside]]
| |
| * [[sodium salicylate]]
| |
| * [[sodium thiosalicylate]]
| |
| * [[sodium valproate]]
| |
| * [[Solfoton]]
| |
| * [[solotuss]]
| |
| * [[Soma]]
| |
| * [[Sominex]]
| |
| * [[Sominex Maximum Strength Caplet]]
| |
| * [[Somnicaps]]
| |
| * [[Somnote]]
| |
| * [[Sonata]]
| |
| * [[Sorbitrate]]
| |
| * [[Sorine]]
| |
| * [[sotalol]]
| |
| * [[Sotalol Hydrochloride AF]]
| |
| * [[Sotalol Hydrochloride AF(obsolete)]]
| |
| * [[Sparine]]
| |
| * [[spironolactone]]
| |
| * [[Sprycel]]
| |
| * [[St. Joseph Aspirin]]
| |
| * [[St. Joseph Aspirin Adult Chewable]]
| |
| * [[St. Joseph Aspirin Adult EC]]
| |
| * [[Stadol]]
| |
| * [[Stadol NS]]
| |
| * [[Stanback Analgesic]]
| |
| * [[Statex]]
| |
| * [[Stelazine]]
| |
| * [[Streptase]]
| |
| * [[streptokinase]]
| |
| * [[Stress Maximum Strength]]
| |
| * [[Strifon Fort]]
| |
| * [[Subutex]]
| |
| * [[sulfinpyrazone]]
| |
| * [[sulindac]]
| |
| * [[Tanacof-XR]]
| |
| * [[TanaHist-PD]]
| |
| * [[Tasigna]]
| |
| * [[Tasmar]]
| |
| * [[Tavist]]
| |
| * [[Tavist Allergy]]
| |
| * [[Tavist-1]]
| |
| * [[Taztia XT]]
| |
| * [[Tegretol]]
| |
| * [[Tegretol XR]]
| |
| * [[telmisartan]]
| |
| * [[Temaril]]
| |
| * [[temazepam]]
| |
| * [[tenecteplase]]
| |
| * [[Tenex]]
| |
| * [[Tenormin]]
| |
| * [[terazosin]]
| |
| * [[terbinafine]]
| |
| * [[Testomar]]
| |
| * [[Teveten]]
| |
| * [[thalidomide]]
| |
| * [[Thalitone]]
| |
| * [[Thalomid]]
| |
| * [[Theraflu Thin Strips Multi Symptom]]
| |
| * [[Therapy Bayer]]
| |
| * [[thiothixene]]
| |
| * [[Thorazine]]
| |
| * [[Thrombate III]]
| |
| * [[Thybine]]
| |
| * [[tiagabine]]
| |
| * [[Tiazac]]
| |
| * [[Ticlid]]
| |
| * [[ticlopidine]]
| |
| * [[Ticon]]
| |
| * [[Tigan]]
| |
| * [[timolol]]
| |
| * [[tinzaparin]]
| |
| * [[tirofiban]]
| |
| * [[tissue plasminogen activator]]
| |
| * [[tizanidine]]
| |
| * [[TNKase]]
| |
| * [[tolcapone]]
| |
| * [[Tolectin]]
| |
| * [[Tolectin 600]]
| |
| * [[Tolectin DS]]
| |
| * [[tolmetin]]
| |
| * [[Topamax]]
| |
| * [[Topamax Sprinkle]]
| |
| * [[topiramate]]
| |
| * [[Toprol-XL]]
| |
| * [[Toradol]]
| |
| * [[Toradol IM]]
| |
| * [[Toradol IV/IM]]
| |
| * [[torsemide]]
| |
| * [[tositumomab]]
| |
| * [[Total Allergy]]
| |
| * [[TPA]]
| |
| * [[Trancopal]]
| |
| * [[Trandate]]
| |
| * [[trandolapril]]
| |
| * [[Tranxene SD]]
| |
| * [[Tranxene T-Tab]]
| |
| * [[treprostinil]]
| |
| * [[Tri-Buffered Aspirin]]
| |
| * [[Triaminic Allergy]]
| |
| * [[Triaminic Thin Strips Cough & Runny Nose]]
| |
| * [[triamterene]]
| |
| * [[triazolam]]
| |
| * [[trichlormethiazide]]
| |
| * [[Tridil]]
| |
| * [[Tridione]]
| |
| * [[trifluoperazine]]
| |
| * [[triflupromazine]]
| |
| * [[Trihexane]]
| |
| * [[trihexyphenidyl]]
| |
| * [[Trilafon]]
| |
| * [[trimeprazine]]
| |
| * [[trimethadione]]
| |
| * [[trimethaphan camsylate]]
| |
| * [[trimethobenzamide]]
| |
| * [[tripelennamine]]
| |
| * [[Tripohist]]
| |
| * [[triprolidine]]
| |
| * [[triprolidine extended release]]
| |
| * [[troglitazone]]
| |
| * [[Trux-adryl]]
| |
| * [[Tusal]]
| |
| * [[Tusstat]]
| |
| * [[Twilite]]
| |
| * [[Uni-Tann]]
| |
| * [[Unisom]]
| |
| * [[Unisom Sleepgels Maximum Strength]]
| |
| * [[Univasc]]
| |
| * [[Uprima]]
| |
| * [[Urispas]]
| |
| * [[urokinase]]
| |
| * [[Uroxatral]]
| |
| * [[V-Gan-25]]
| |
| * [[V-Gan-50]]
| |
| * [[Valium]]
| |
| * [[valproic acid]]
| |
| * [[Valrelease]]
| |
| * [[valsartan]]
| |
| * [[Valu-Dryl]]
| |
| * [[Vanadom]]
| |
| * [[Vasotec]]
| |
| * [[VaZol]]
| |
| * [[Ventavis]]
| |
| * [[Versed]]
| |
| * [[Visken]]
| |
| * [[Vistacon]]
| |
| * [[Vistacot]]
| |
| * [[Vistaject-50]]
| |
| * [[Vistaril]]
| |
| * [[Vistaril IM]]
| |
| * [[Vistazine]]
| |
| * [[Vistazine 50]]
| |
| * [[Voltaren]]
| |
| * [[Voltaren-XR]]
| |
| * [[Wal-finate]]
| |
| * [[warfarin]]
| |
| * [[Wytensin]]
| |
| * [[Xanax]]
| |
| * [[Xanax XR]]
| |
| * [[Xigris]]
| |
| * [[Xyzal]]
| |
| * [[XYZALL]]
| |
| * [[Y-90 Zevalin]]
| |
| * [[Yocon]]
| |
| * [[Yohimar]]
| |
| * [[Yohimbe]]
| |
| * [[yohimbine]]
| |
| * [[Yohimex]]
| |
| * [[Yoman]]
| |
| * [[Yovital]]
| |
| * [[YSP Aspirin]]
| |
| * [[zaleplon]]
| |
| * [[Zanaflex]]
| |
| * [[Zaponex]]
| |
| * [[Zarontin]]
| |
| * [[Zaroxolyn]]
| |
| * [[Zebeta]]
| |
| * [[Zero-Order Release]]
| |
| * [[Zestril]]
| |
| * [[Zetran]]
| |
| * [[ziconotide]]
| |
| * [[ziprasidone]]
| |
| * [[zolpidem]]
| |
| * [[zolpidem extended release]]
| |
| * [[Zonegran]]
| |
| * [[zonisamide]]
| |
| * [[Zorprin]]
| |
| * [[Zymine]]
| |
| * [[Zymine XR]]
| |
| * [[Zyprexa]]
| |
| * [[Zyprexa Zydis]]
| |
| * [[Zyrtec]]
| |
| * [[Zyrtec Hives]]
| |
| {{refend}}
| |
|
| |
|
| ==Minor Interactions== | | ===Alcohol=== |
| {{refbegin|3}}
| |
| * [[atomoxetine]]
| |
| * [[cimetidine]]
| |
| * [[Haldol]]
| |
| * [[Haldol Decanoate]]
| |
| * [[haloperidol]]
| |
| * [[haloperidol decanoate]]
| |
| * [[Strattera]]
| |
| * [[Tagamet]]
| |
| * [[Tagamet HB]]
| |
| {{refend}}
| |
|
| |
|
| | A single dose of [[ethanol]] (0.5 g/kg) had no effect on the pharmacokinetics of venlafaxine or O-desmethylvenlafaxine (ODV) when venlafaxine was administered at 150 mg/day in 15 healthy male subjects. Additionally, administration of venlafaxine in a stable regimen did not exaggerate the psychomotor and psychometric effects induced by [[ethanol]] in these same subjects when they were not receiving venlafaxine. |
|
| |
|
| | ===[[Cimetidine]]=== |
|
| |
|
| {{FDA}}
| | Concomitant administration of [[Cimetidine]] and venlafaxine in a steady-state study for both drugs resulted in inhibition of first-pass metabolism of venlafaxine in 18 healthy subjects. The oral clearance of venlafaxine was reduced by about 43%, and the exposure (AUC) and maximum concentration (Cmax) of the drug were increased by about 60%. However, coadministration of [[Cimetidine]] had no apparent effect on the pharmacokinetics of ODV, which is present in much greater quantity in the circulation than venlafaxine. The overall pharmacological activity of venlafaxine plus ODV is expected to increase only slightly, and no dosage adjustment should be necessary for most normal adults. However, for patients with pre-existing hypertension, and for elderly patients or patients with hepatic dysfunction, the interaction associated with the concomitant use of venlafaxine and [[Cimetidine]] is not known and potentially could be more pronounced. Therefore, caution is advised with such patients. |
|
| |
|
| | ===[[diazepam]]=== |
|
| |
|
| | Under steady-state conditions for venlafaxine administered at 150 mg/day, a single 10 mg dose of [[diazepam]] did not appear to affect the pharmacokinetics of either venlafaxine or ODV in 18 healthy male subjects. Venlafaxine also did not have any effect on the pharmacokinetics of [[diazepam]] or its active metabolite, desmethyl[[diazepam]], or affect the psychomotor and psychometric effects induced by [[diazepam]]. |
|
| |
|
| | ===[[Haloperidol]]=== |
|
| |
|
| | Venlafaxine administered under steady-state conditions at 150 mg/day in 24 healthy subjects decreased total oral-dose clearance (Cl/F) of a single 2 mg dose of [[Haloperidol]] by 42%, which resulted in a 70% increase in [[Haloperidol]] AUC. In addition, the [[Haloperidol]] Cmax increased 88% when coadministered with venlafaxine, but the [[Haloperidol]] elimination half-life (t1/2) was unchanged. The mechanism explaining this finding is unknown. |
|
| |
|
| | ===[[Lithium]]=== |
| | |
| | The steady-state pharmacokinetics of venlafaxine administered at 150 mg/day were not affected when a single 600 mg oral dose of [[Lithium]] was administered to 12 healthy male subjects. ODV also was unaffected. Venlafaxine had no effect on the pharmacokinetics of [[Lithium]] (see also CNS-Active Drugs, below). |
| | |
| | ===Drugs Highly Bound to Plasma Proteins=== |
| | |
| | Venlafaxine is not highly bound to plasma proteins; therefore, administration of Effexor XR to a patient taking another drug that is highly protein bound should not cause increased free concentrations of the other drug. |
| | |
| | ===Drugs that Interfere with Hemostasis (e.g., [[NSAIDs]], [[Aspirin]], and [[Warfarin]])=== |
| | |
| | Serotonin release by platelets plays an important role in hemostasis. Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an [[NSAID]] or [[aspirin]] may potentiate this risk of bleeding. Altered anticoagulant effects, including increased bleeding, have been reported when [[SSRIs]] and [[SNRIs]] are coadministered with [[warfarin]]. Patients receiving [[warfarin]] therapy should be carefully monitored when Effexor XR is initiated or discontinued. |
| | |
| | ===Drugs that Inhibit Cytochrome P450 [[isoenzyme]]s=== |
| | |
| | ====CYP2D6 Inhibitors==== |
| | |
| | In vitro and in vivo studies indicate that venlafaxine is metabolized to its active metabolite, ODV, by CYP2D6, the [[isoenzyme]] that is responsible for the genetic polymorphism seen in the metabolism of many antidepressants. Therefore, the potential exists for a drug interaction between drugs that inhibit CYP2D6-mediated metabolism of venlafaxine, reducing the metabolism of venlafaxine to ODV, resulting in increased plasma concentrations of venlafaxine and decreased concentrations of the active metabolite. CYP2D6 inhibitors such as [[quinidine]] would be expected to do this, but the effect would be similar to what is seen in patients who are genetically CYP2D6 poor metabolizers (see Metabolism and Excretion under CLINICAL PHARMACOLOGY). Therefore, no dosage adjustment is required when venlafaxine is coadministered with a CYP2D6 inhibitor. |
| | |
| | ====[[ketoconazole]]==== |
| | |
| | A pharmacokinetic study with [[ketoconazole]] 100 mg b.i.d. with a single dose of venlafaxine 50 mg in extensive metabolizers (EM; n = 14) and 25 mg in poor metabolizers (PM; n = 6) of CYP2D6 resulted in higher plasma concentrations of both venlafaxine and O-desmethylvenlafaxine (ODV) in most subjects following administration of [[ketoconazole]]. Venlafaxine Cmax increased by 26% in EM subjects and 48% in PM subjects. Cmax values for ODV increased by 14% and 29% in EM and PM subjects, respectively. |
| | |
| | Venlafaxine AUC increased by 21% in EM subjects and 70% in PM subjects (range in PMs -2% to 206%), and AUC values for ODV increased by 23% and 33% in EM and PM (range in PMs -38% to 105%) subjects, respectively. Combined AUCs of venlafaxine and ODV increased on average by approximately 23% in EMs and 53% in PMs (range in PMs 4% to 134%). |
| | |
| | Concomitant use of CYP3A4 inhibitors and venlafaxine may increase levels of venlafaxine and ODV. Therefore, caution is advised if a patient's therapy includes a CYP3A4 inhibitor and venlafaxine concomitantly. |
| | |
| | ===Drugs Metabolized by Cytochrome P450 [[isoenzyme]]s=== |
| | |
| | ====CYP2D6==== |
| | |
| | In vitro studies indicate that venlafaxine is a relatively weak inhibitor of CYP2D6. These findings have been confirmed in a clinical drug interaction study comparing the effect of venlafaxine with that of [[fluoxetine]] on the CYP2D6-mediated metabolism of [[dextromethorphan]] to [[dextrorphan]]. |
| | |
| | ====[[Imipramine]]==== |
| | |
| | Venlafaxine did not affect the pharmacokinetics of [[Imipramine]] and 2-OH-[[Imipramine]]. However, desipramine AUC, Cmax, and Cmin increased by about 35% in the presence of venlafaxine. The 2-OH-desipramine AUC's increased by at least 2.5 fold (with venlafaxine 37.5 mg q12h) and by 4.5 fold (with venlafaxine 75 mg q12h). [[Imipramine]] did not affect the pharmacokinetics of venlafaxine and ODV. The clinical significance of elevated 2-OH-desipramine levels is unknown. |
| | |
| | ====Metoprolol==== |
| | |
| | Concomitant administration of venlafaxine (50 mg every 8 hours for 5 days) and [[Metoprolol]] (100 mg every 24 hours for 5 days) to 18 healthy male subjects in a pharmacokinetic interaction study for both drugs resulted in an increase of plasma concentrations of [[Metoprolol]] by approximately 30–40% without altering the plasma concentrations of its active metabolite, α-hydroxy[[Metoprolol]]. [[Metoprolol]] did not alter the pharmacokinetic profile of venlafaxine or its active metabolite, O-desmethylvenlafaxine. |
| | |
| | Venlafaxine appeared to reduce the blood pressure lowering effect of [[Metoprolol]] in this study. The clinical relevance of this finding for hypertensive patients is unknown. Caution should be exercised with co-administration of venlafaxine and [[Metoprolol]]. |
| | |
| | Venlafaxine treatment has been associated with dose-related increases in blood pressure in some patients. It is recommended that patients receiving Effexor XR have regular monitoring of blood pressure (see WARNINGS). |
| | |
| | ====Risperidone==== |
| | |
| | Venlafaxine administered under steady-state conditions at 150 mg/day slightly inhibited the CYP2D6-mediated metabolism of [[Risperidone]] (administered as a single 1 mg oral dose) to its active metabolite, 9-hydroxy[[Risperidone]], resulting in an approximate 32% increase in [[Risperidone]] AUC. However, venlafaxine coadministration did not significantly alter the pharmacokinetic profile of the total active moiety ([[Risperidone]] plus 9-hydroxy[[Risperidone]]). |
| | |
| | ===CYP3A4=== |
| | |
| | Venlafaxine did not inhibit CYP3A4 in vitro. This finding was confirmed in vivo by clinical drug interaction studies in which venlafaxine did not inhibit the metabolism of several CYP3A4 substrates, including [[alprazolam]], [[diazepam]], and [[terfenadine]]. |
| | |
| | ====Indinavir==== |
| | |
| | In a study of 9 healthy volunteers, venlafaxine administered under steady-state conditions at 150 mg/day resulted in a 28% decrease in the AUC of a single 800 mg oral dose of [[indinavir]] and a 36% decrease in [[indinavir]] Cmax. [[Indinavir]] did not affect the pharmacokinetics of venlafaxine and ODV. The clinical significance of this finding is unknown. |
| | |
| | ===CYP1A2=== |
| | |
| | Venlafaxine did not inhibit CYP1A2 in vitro. This finding was confirmed in vivo by a clinical drug interaction study in which venlafaxine did not inhibit the metabolism of caffeine, a CYP1A2 substrate. |
| | |
| | ===CYP2C9=== |
| | |
| | Venlafaxine did not inhibit CYP2C9 in vitro. In vivo, venlafaxine 75 mg by mouth every 12 hours did not alter the pharmacokinetics of a single 500 mg dose of tolbutamide or the CYP2C9 mediated formation of 4-hydroxy-tolbutamide. |
| | |
| | ===CYP2C19=== |
| | |
| | Venlafaxine did not inhibit the metabolism of [[diazepam]], which is partially metabolized by CYP2C19 (see [[diazepam]] above). |
| | |
| | Monoamine Oxidase Inhibitors |
| | |
| | See CONTRAINDICATIONS, WARNINGS, and DOSAGE AND ADMINISTRATION. |
| | |
| | ===CNS-Active Drugs=== |
| | |
| | The risk of using venlafaxine in combination with other CNS-active drugs has not been systematically evaluated (except in the case of those CNS-active drugs noted above). Consequently, caution is advised if the concomitant administration of venlafaxine and such drugs is required. (See CONTRAINDICATIONS and WARNINGS, Serotonin Syndrome) |
| | |
| | ====Serotonergic Drugs==== |
| | |
| | See CONTRAINDICATIONS, WARNINGS, and DOSAGE AND ADMINISTRATION. |
| | |
| | ====Triptans==== |
| | |
| | There have been rare postmarketing reports of serotonin syndrome with use of an [[SSRI]] and a [[triptan]]. If concomitant treatment of Effexor XR with a [[triptan]] is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases (see WARNINGS, Serotonin Syndrome). |
| | |
| | ===Drugs that Prolong the QT Interval=== |
| | |
| | The risk of QTc prolongation and/or ventricular [[arrhythmia]]s (e.g., TdP) is increased with concomitant use of other drugs which prolong the QTc interval (e.g., some antipsychotics and antibiotics) (see PRECAUTIONS, Use in Patients With Concomitant Illness). |
| | |
| | ===Drug-Laboratory Test Interactions=== |
| | |
| | False-positive urine immunoassay screening tests for [[phencyclidine]] (PCP) and [[amphetamine]] have been reported in patients taking venlafaxine. This is due to lack of specificity of the screening tests. False positive test results may be expected for several days following discontinuation of venlafaxine therapy. Confirmatory tests, such as gas chromatography/mass spectrometry, will distinguish venlafaxine from PCP and amphetamine. |
| | |
| | ====Electroconvulsive Therapy==== |
| | |
| | There are no clinical data establishing the benefit of electroconvulsive therapy combined with Effexor XR (venlafaxine hydrochloride) extended-release capsules treatment. |
| | |
| | Postmarketing Spontaneous Drug Interaction Reports |
| | |
| | See ADVERSE REACTIONS, Postmarketing Reports.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = EFFEXOR XR (VENLAFAXINE HYDROCHLORIDE) CAPSULE, EXTENDED RELEASE [WYETH PHARMACEUTICALS COMPANY, A SUBSIDIARY OF PFIZER INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=53c3e7ac-1852-4d70-d2b6-4fca819acf26 | publisher = | date = | accessdate = 7 February 2014 }}</ref> |
| | |
| | ==References== |
| | |
| | {{Reflist|2}} |
| | |
| | [[Category:Antidepressants]] |
| [[Category:Drugs]] | | [[Category:Drugs]] |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
Drug Interactions
As with all drugs, the potential for interaction by a variety of mechanisms is a possibility.
Alcohol
A single dose of ethanol (0.5 g/kg) had no effect on the pharmacokinetics of venlafaxine or O-desmethylvenlafaxine (ODV) when venlafaxine was administered at 150 mg/day in 15 healthy male subjects. Additionally, administration of venlafaxine in a stable regimen did not exaggerate the psychomotor and psychometric effects induced by ethanol in these same subjects when they were not receiving venlafaxine.
Concomitant administration of Cimetidine and venlafaxine in a steady-state study for both drugs resulted in inhibition of first-pass metabolism of venlafaxine in 18 healthy subjects. The oral clearance of venlafaxine was reduced by about 43%, and the exposure (AUC) and maximum concentration (Cmax) of the drug were increased by about 60%. However, coadministration of Cimetidine had no apparent effect on the pharmacokinetics of ODV, which is present in much greater quantity in the circulation than venlafaxine. The overall pharmacological activity of venlafaxine plus ODV is expected to increase only slightly, and no dosage adjustment should be necessary for most normal adults. However, for patients with pre-existing hypertension, and for elderly patients or patients with hepatic dysfunction, the interaction associated with the concomitant use of venlafaxine and Cimetidine is not known and potentially could be more pronounced. Therefore, caution is advised with such patients.
Under steady-state conditions for venlafaxine administered at 150 mg/day, a single 10 mg dose of diazepam did not appear to affect the pharmacokinetics of either venlafaxine or ODV in 18 healthy male subjects. Venlafaxine also did not have any effect on the pharmacokinetics of diazepam or its active metabolite, desmethyldiazepam, or affect the psychomotor and psychometric effects induced by diazepam.
Venlafaxine administered under steady-state conditions at 150 mg/day in 24 healthy subjects decreased total oral-dose clearance (Cl/F) of a single 2 mg dose of Haloperidol by 42%, which resulted in a 70% increase in Haloperidol AUC. In addition, the Haloperidol Cmax increased 88% when coadministered with venlafaxine, but the Haloperidol elimination half-life (t1/2) was unchanged. The mechanism explaining this finding is unknown.
The steady-state pharmacokinetics of venlafaxine administered at 150 mg/day were not affected when a single 600 mg oral dose of Lithium was administered to 12 healthy male subjects. ODV also was unaffected. Venlafaxine had no effect on the pharmacokinetics of Lithium (see also CNS-Active Drugs, below).
Drugs Highly Bound to Plasma Proteins
Venlafaxine is not highly bound to plasma proteins; therefore, administration of Effexor XR to a patient taking another drug that is highly protein bound should not cause increased free concentrations of the other drug.
Drugs that Interfere with Hemostasis (e.g., NSAIDs, Aspirin, and Warfarin)
Serotonin release by platelets plays an important role in hemostasis. Epidemiological studies of the case-control and cohort design that have demonstrated an association between use of psychotropic drugs that interfere with serotonin reuptake and the occurrence of upper gastrointestinal bleeding have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding. Altered anticoagulant effects, including increased bleeding, have been reported when SSRIs and SNRIs are coadministered with warfarin. Patients receiving warfarin therapy should be carefully monitored when Effexor XR is initiated or discontinued.
Drugs that Inhibit Cytochrome P450 isoenzymes
CYP2D6 Inhibitors
In vitro and in vivo studies indicate that venlafaxine is metabolized to its active metabolite, ODV, by CYP2D6, the isoenzyme that is responsible for the genetic polymorphism seen in the metabolism of many antidepressants. Therefore, the potential exists for a drug interaction between drugs that inhibit CYP2D6-mediated metabolism of venlafaxine, reducing the metabolism of venlafaxine to ODV, resulting in increased plasma concentrations of venlafaxine and decreased concentrations of the active metabolite. CYP2D6 inhibitors such as quinidine would be expected to do this, but the effect would be similar to what is seen in patients who are genetically CYP2D6 poor metabolizers (see Metabolism and Excretion under CLINICAL PHARMACOLOGY). Therefore, no dosage adjustment is required when venlafaxine is coadministered with a CYP2D6 inhibitor.
A pharmacokinetic study with ketoconazole 100 mg b.i.d. with a single dose of venlafaxine 50 mg in extensive metabolizers (EM; n = 14) and 25 mg in poor metabolizers (PM; n = 6) of CYP2D6 resulted in higher plasma concentrations of both venlafaxine and O-desmethylvenlafaxine (ODV) in most subjects following administration of ketoconazole. Venlafaxine Cmax increased by 26% in EM subjects and 48% in PM subjects. Cmax values for ODV increased by 14% and 29% in EM and PM subjects, respectively.
Venlafaxine AUC increased by 21% in EM subjects and 70% in PM subjects (range in PMs -2% to 206%), and AUC values for ODV increased by 23% and 33% in EM and PM (range in PMs -38% to 105%) subjects, respectively. Combined AUCs of venlafaxine and ODV increased on average by approximately 23% in EMs and 53% in PMs (range in PMs 4% to 134%).
Concomitant use of CYP3A4 inhibitors and venlafaxine may increase levels of venlafaxine and ODV. Therefore, caution is advised if a patient's therapy includes a CYP3A4 inhibitor and venlafaxine concomitantly.
Drugs Metabolized by Cytochrome P450 isoenzymes
CYP2D6
In vitro studies indicate that venlafaxine is a relatively weak inhibitor of CYP2D6. These findings have been confirmed in a clinical drug interaction study comparing the effect of venlafaxine with that of fluoxetine on the CYP2D6-mediated metabolism of dextromethorphan to dextrorphan.
Venlafaxine did not affect the pharmacokinetics of Imipramine and 2-OH-Imipramine. However, desipramine AUC, Cmax, and Cmin increased by about 35% in the presence of venlafaxine. The 2-OH-desipramine AUC's increased by at least 2.5 fold (with venlafaxine 37.5 mg q12h) and by 4.5 fold (with venlafaxine 75 mg q12h). Imipramine did not affect the pharmacokinetics of venlafaxine and ODV. The clinical significance of elevated 2-OH-desipramine levels is unknown.
Metoprolol
Concomitant administration of venlafaxine (50 mg every 8 hours for 5 days) and Metoprolol (100 mg every 24 hours for 5 days) to 18 healthy male subjects in a pharmacokinetic interaction study for both drugs resulted in an increase of plasma concentrations of Metoprolol by approximately 30–40% without altering the plasma concentrations of its active metabolite, α-hydroxyMetoprolol. Metoprolol did not alter the pharmacokinetic profile of venlafaxine or its active metabolite, O-desmethylvenlafaxine.
Venlafaxine appeared to reduce the blood pressure lowering effect of Metoprolol in this study. The clinical relevance of this finding for hypertensive patients is unknown. Caution should be exercised with co-administration of venlafaxine and Metoprolol.
Venlafaxine treatment has been associated with dose-related increases in blood pressure in some patients. It is recommended that patients receiving Effexor XR have regular monitoring of blood pressure (see WARNINGS).
Risperidone
Venlafaxine administered under steady-state conditions at 150 mg/day slightly inhibited the CYP2D6-mediated metabolism of Risperidone (administered as a single 1 mg oral dose) to its active metabolite, 9-hydroxyRisperidone, resulting in an approximate 32% increase in Risperidone AUC. However, venlafaxine coadministration did not significantly alter the pharmacokinetic profile of the total active moiety (Risperidone plus 9-hydroxyRisperidone).
CYP3A4
Venlafaxine did not inhibit CYP3A4 in vitro. This finding was confirmed in vivo by clinical drug interaction studies in which venlafaxine did not inhibit the metabolism of several CYP3A4 substrates, including alprazolam, diazepam, and terfenadine.
Indinavir
In a study of 9 healthy volunteers, venlafaxine administered under steady-state conditions at 150 mg/day resulted in a 28% decrease in the AUC of a single 800 mg oral dose of indinavir and a 36% decrease in indinavir Cmax. Indinavir did not affect the pharmacokinetics of venlafaxine and ODV. The clinical significance of this finding is unknown.
CYP1A2
Venlafaxine did not inhibit CYP1A2 in vitro. This finding was confirmed in vivo by a clinical drug interaction study in which venlafaxine did not inhibit the metabolism of caffeine, a CYP1A2 substrate.
CYP2C9
Venlafaxine did not inhibit CYP2C9 in vitro. In vivo, venlafaxine 75 mg by mouth every 12 hours did not alter the pharmacokinetics of a single 500 mg dose of tolbutamide or the CYP2C9 mediated formation of 4-hydroxy-tolbutamide.
CYP2C19
Venlafaxine did not inhibit the metabolism of diazepam, which is partially metabolized by CYP2C19 (see diazepam above).
Monoamine Oxidase Inhibitors
See CONTRAINDICATIONS, WARNINGS, and DOSAGE AND ADMINISTRATION.
CNS-Active Drugs
The risk of using venlafaxine in combination with other CNS-active drugs has not been systematically evaluated (except in the case of those CNS-active drugs noted above). Consequently, caution is advised if the concomitant administration of venlafaxine and such drugs is required. (See CONTRAINDICATIONS and WARNINGS, Serotonin Syndrome)
Serotonergic Drugs
See CONTRAINDICATIONS, WARNINGS, and DOSAGE AND ADMINISTRATION.
Triptans
There have been rare postmarketing reports of serotonin syndrome with use of an SSRI and a triptan. If concomitant treatment of Effexor XR with a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases (see WARNINGS, Serotonin Syndrome).
Drugs that Prolong the QT Interval
The risk of QTc prolongation and/or ventricular arrhythmias (e.g., TdP) is increased with concomitant use of other drugs which prolong the QTc interval (e.g., some antipsychotics and antibiotics) (see PRECAUTIONS, Use in Patients With Concomitant Illness).
Drug-Laboratory Test Interactions
False-positive urine immunoassay screening tests for phencyclidine (PCP) and amphetamine have been reported in patients taking venlafaxine. This is due to lack of specificity of the screening tests. False positive test results may be expected for several days following discontinuation of venlafaxine therapy. Confirmatory tests, such as gas chromatography/mass spectrometry, will distinguish venlafaxine from PCP and amphetamine.
Electroconvulsive Therapy
There are no clinical data establishing the benefit of electroconvulsive therapy combined with Effexor XR (venlafaxine hydrochloride) extended-release capsules treatment.
Postmarketing Spontaneous Drug Interaction Reports
See ADVERSE REACTIONS, Postmarketing Reports.[1]
References