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| ==History== | | ==History== |
| A detailed history is important to elicit any recent medications, any risk of [[hepatitis]] infection, or any recent diagnosis with a connective tissue disorder such as [[lupus erythematosus| systemic lupus erythematosus]] ([[SLE]]).
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| ==Symptoms== | | ==Symptoms== |
| Patients usually present with systemic symptoms with single or multiorgan dysfunction.
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| Common (and nonspecific) complaints include
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| * [[Fatigue]] | |
| * [[Weakness]]
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| * [[Fever]]
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| * [[Arthralgias]]
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| * [[Abdominal pain]]
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| * [[Hypertension]]
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| * [[Renal insufficiency]]
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| * [[Neurologic dysfunction]]
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| The following symptoms should raise a strong suspicion of a vasculitis:
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| *'''[[Mononeuritis multiplex]]'''. Also known as asymmetric polyneuropathy is highly suggestive of vasculitis, since [[diabetes]] is the only other cause of this.
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| *'''Palpable purpura'''. If patients have this in isolation, it is most likely due to cutaneous leukocytoclastic vasculitis. If the purpura is in combination with systemic organ involvement, it is most likely to be Henoch-Schonlein purpura or microscopic polyarteritis.
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| *'''Pulmonary-Renal'''. Patients with hemoptysis and renal involvement are likely to have [[Wegener's granulomatosis]], [[microscopic polyangiitis]], or anti-GBM disease ([[Goodpasture's syndrome]]).
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| Other relatively common symptoms include:
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| * [[Claudication]] of extremities
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| * New onset [[headache]] with localized tenderness - [[temporal arteritis]]
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| * Unexplained [[weight loss]] > 4 kg, [[testicular pain]] - [[Polyarteritis nodosa]]
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| * Nasal or oral inflammation (oral ulcers or purulent/bloody nasal discharge, may be painful) - [[Wegener's granulomatosis]]
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| * [[Asthma]] (history of [[wheezing]] or presently wheezing) - [[Churg-Strauss syndrome|Churg-Strauss arteritis]]
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| * [[GI bleed]], [[Hematuria]] - [[Henoch-Schonlein purpura]]
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| ==References== | | ==References== |
| {{Reflist|2}} | | {{Reflist|2}} |
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| | [[Category:Rheumatology]] |
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| {{WH}} | | {{WH}} |
| {{WS}} | | {{WS}} |