Vaginal bleeding

Template:DiseaseDisorder infobox Template:Search infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Vaginal bleeding refers to bleeding in females that are either a physiologic response during the non-conceptional menstrual cycle or caused by hormonal or organic problems of the reproductive system. Vaginal bleeding may occur at any age, but always needs investigation when encountered in female children or postmenopausal women. Vaginal bleeding during pregnancy may indicate a possible pregnancy complication that needs to be medically addressed.

Anatomy

Blood loss per vaginam (Latin: from the vagina) typically arises from the lining of the uterus (endometrium), but may arise from uterine or cervical lesions, the vagina, and rarely from the Fallopian tube. During pregnancy it is usually but not always related to the pregnancy itself. Rarely, the blood may actually arise from the urinary tract (hematuria), although the vast majority of women can identify the difference. It can also be a sign of vaginal cancer.

Causes

• Drug Side Effect:
  • Clomiphene
  • Estradiol valerate and estradiol valerate/dienogest
  • Ganirelix
  • Tiagabine
  • Trimethadione

Bleeding in Children

Bleeding before the expected time of menarche could be a sign of precocious puberty. Other possible causes include the presence of a foreign body in the vagina, molestation, vaginal infection (vaginitis), and rarely, a tumor.

Premenopausal women

• Menstruation. Exceptionally heavy bleeding during periods is termed menorrhagia or hypermenorrhea, while light bleeding is called hypomenorrhea.
• If bleeding occurs between periods, this is not necessarily pathological, but it is termed intermenstrual bleeding. If no period can be identified due to the unpredictable bleeding, metrorrhagia is used.
• Dysfunctional uterine bleeding is a common cause of menorrhagia and irregular bleeding. It is due to a hormonal imbalance, and symptoms can be managed by use of hormonal contraception (although hormonal contraception does not treat the underlying cause of the imbalance). If it is due to polycystic ovary syndrome, weight loss may help, and infertility may respond to clomifene citrate.
• Uterine fibroids (leiomyoma) are benign tumors of the uterus.
• Cervical cancer may occur at premenopausal age, and often presents with "contact bleeding" (e.g. after sexual intercourse)
• Uterine cancer will lead to irregular and often prolonged bleeding.

Pregnant women

During pregnancy: mild to moderate blood loss may be due to rupture of a small vein on the outer rim of the placenta. It can also herald a miscarriage or ectopic pregnancy, which is why urgent ultrasound is required to separate the two causes. Bleeding in early pregnancy may be a sign of a threatened or incomplete miscarriage. In the second or third trimester a placenta previa (a placenta partially or completely overlying the cervix) may bleed quite severely. Placental abruption is often associated with uterine bleeding as well as uterine pain.

• Drugs: Mifepristone

Postmenopausal women

Any vaginal bleeding after the menopause needs to be medically assessed.

• Atrophy of the endometrium may cause bleeding
• Endometrial cancer often presents with blood loss in postmenopausal women
• Drugs:Spironolactone

Investigation

The diagnosis can often be made on the basis of the bleeding history, physical examination, and other medical tests as appropriate. Typically a pregnancy test and additional hormonal tests, a Pap smear, a transvaginal ultrasound are needed. If bleeding was excessive or prolonged, a CBC may be useful to check for anemia. Abnormal endometrium may have to be investigated by a hysteroscopy with a biopsy or a dilation and curettage.

Differential Diagnosis

In alphabetical order.

• Abortion
• Adherent placental residue
• Adnexitis
• Adrenal disease
• Atonic secondary bleeding
• Carcinoma
• Cervical Cancer
• Cervical ectopia
• Cervical erosion
• Cervical neoplasms
• Cervical polyp
• Cervicitis
• Chorionepithelioma
• Colpitis Senilis
• Corpus luteum deficiency syndrome
• Ectopic Pregnancy
• Endometrial polyps
• Endometriosis
• Endometritis
• Estrogen-progestogen therapy
• Estrogen breakthrough bleeding
• Fibrinogen deficiency
• Follicle persistence
• Granulosa cell tumor
• Hydatidiform mole
• Hypothalamic or pituitary lesion
• Inadequate corpus luteum
• Injuries
• Intrauterine device (IUD)
• Lacerated placenta
• Midcycle ovulatory bleeding
• Myoma
• Neoplasms
• Placenta Previa
• Postcoital hemorrhage
• Premature placental abruption
• Prolapsed uterus
• Rupture hemorrhage
• Ruptured uterus
• Stress/psychogenic factors
• Thyroid disease
• Trauma
• Uterine adenomytosis
• Uterine leiomyomas
• Vaginal Cancer
• Vaginal infections
• Vaginal varices
• Varicosis of the vagina
• Velamentous insertion
• Vulvar Cancer

Treatment

The treatment will be directed at the cause. Hormonal bleeding problems during the reproductive years, if bothersome to the woman, are frequently managed by use of combined oral contraceptive pills.

Contraindicated medications

Vaginal Bleeding is considered an absolute contraindication to the use of the following medications:

• Hydroxyprogesterone caproate, Dinoprostone

Complications

A possible complication from protracted vaginal blood loss is iron deficiency anemia, which can develop insidiously. Eliminating the cause will resolve the anemia, although some women require iron supplements or blood transfusions to improve the anemia.

References

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