Uveal melanoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D., Simrat Sarai, M.D. [2]

Overview

Uveal melanoma may be classified according to cell type into 5 subtypes: Spindle A, spindle B, epitheliolid, mixed, and necrotic. Uveal melanoma may also be classified according to its location into 2 types, anterior uveal melanoma which contain iris melanoma, and posterior uveal melanoma which contains ciliary bode melanoma and chroidal melanoma.

Classification

Uveal melanoma may be classified according to cell type into 5 subtypes: Spindle A, spindle B, epitheliolid, mixed, and necrotic.

Cell type	Explanation
Spindle A	Fine nuclear chromatin Cells with small spindle nuclei and central dark stripe No distinct nucleoli Rare mitotic features
Spindle B	Commen Coarse nuclear chromatin Distinct nucleoli Rare mitotic features
Epithelioid	Rarest Large round nuclei Prominent nucleoli Mitotic features are common
Mixed	Most common Contains both spindle cells and epithelioil cells
Necrotic	uncommon Necrotic tumore with unidentifiable cell type

Uveal melanoma may also be classified according to its location into 2 types:

• Anterior uveal melanoma
  • Iris melanoma
• Posterior uveal melanoma
  • Ciliary body melanoma
  • Chroidal melanoma

source: Fahimeh Shojaei, M.D.