Uveal melanoma classification: Difference between revisions
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{{CMG}}{{AE}} {{Fs}}, {{Simrat}} | {{CMG}}{{AE}} {{Fs}}, {{Simrat}} | ||
==Overview== | ==Overview== | ||
Uveal melanoma may be classified according to cell type into 5 subtypes: Spindle A, spindle B, epitheliolid, mixed, and necrotic. Uveal melanoma may also be classified according to its location into 2 types, anterior uveal melanoma which contain iris melanoma, and posterior uveal melanoma which contains ciliary | [[Uvea (anatomy)|Uveal]] [[melanoma]] may be classified according to [[Cell (biology)|cell]] type into 5 subtypes: [[Spindle cells|Spindle]] A, [[Spindle cells|spindle]] B, epitheliolid, mixed, and [[necrotic]]. [[Uvea (anatomy)|Uveal]] [[melanoma]] may also be classified according to its location into 2 types, anterior [[Uvea (anatomy)|uveal]] [[melanoma]] which contain [[iris]] [[melanoma]], and posterior [[Uvea (anatomy)|uveal]] [[melanoma]] which contains [[ciliary body]] [[melanoma]] and chroidal [[melanoma]]. | ||
==Classification== | ==Classification== | ||
Uveal melanoma may be classified according to cell type into 5 subtypes: Spindle A, spindle B, epitheliolid, mixed, and necrotic.<ref name="McLeanFoster1983">{{cite journal|last1=McLean|first1=Ian W.|last2=Foster|first2=Walter D.|last3=Zimmerman|first3=Lorenz E.|last4=Gamel|first4=John W.|title=Modifications of Callender's Classification of Uveal Melanoma at the Armed Forces Institute of Pathology|journal=American Journal of Ophthalmology|volume=96|issue=4|year=1983|pages=502–509|issn=00029394|doi=10.1016/S0002-9394(14)77914-0}}</ref> | [[Uvea (anatomy)|Uveal]] [[melanoma]] may be classified according to [[Cell (biology)|cell]] type into 5 subtypes: [[Spindle cells|Spindle]] A, [[Spindle cells|spindle]] B, epitheliolid, mixed, and [[necrotic]].<ref name="McLeanFoster1983">{{cite journal|last1=McLean|first1=Ian W.|last2=Foster|first2=Walter D.|last3=Zimmerman|first3=Lorenz E.|last4=Gamel|first4=John W.|title=Modifications of Callender's Classification of Uveal Melanoma at the Armed Forces Institute of Pathology|journal=American Journal of Ophthalmology|volume=96|issue=4|year=1983|pages=502–509|issn=00029394|doi=10.1016/S0002-9394(14)77914-0}}</ref> | ||
{| | {| | ||
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! style="background: #DCDCDC; text-align: center;" |Spindle A | ! style="background: #DCDCDC; text-align: center;" |Spindle A | ||
| style="background: #F5F5F5;" | | | style="background: #F5F5F5;" | | ||
* Fine nuclear chromatin | * Fine [[nuclear]] [[chromatin]] | ||
* Cells with small spindle nuclei and central dark stripe | *[[Cell (biology)|Cells]] with small spindle nuclei and central dark stripe | ||
* No distinct nucleoli | * No distinct [[nucleoli]] | ||
* Rare mitotic features | * Rare [[mitotic]] features | ||
|- | |- | ||
! style="background: #DCDCDC; text-align: center;" |Spindle B | ! style="background: #DCDCDC; text-align: center;" |Spindle B | ||
| Line 24: | Line 24: | ||
* Commen | * Commen | ||
* Coarse nuclear chromatin | * Coarse [[nuclear]] [[chromatin]] | ||
* Distinct nucleoli | * Distinct [[nucleoli]] | ||
* Rare mitotic features | * Rare [[mitotic]] features | ||
|- | |- | ||
| Line 32: | Line 32: | ||
| style="background: #F5F5F5;" | | | style="background: #F5F5F5;" | | ||
* Rarest | * Rarest | ||
* Large round nuclei | * Large round [[nuclei]] | ||
* Prominent nucleoli | * Prominent [[nucleoli]] | ||
* Mitotic features are common | *[[Mitotic]] features are common | ||
|- | |- | ||
! style="background: #DCDCDC; text-align: center;" |Mixed | ! style="background: #DCDCDC; text-align: center;" |Mixed | ||
| style="background: #F5F5F5;" | | | style="background: #F5F5F5;" | | ||
* Most common | * Most common | ||
* Contains both spindle cells and epithelioil cells | * Contains both [[spindle cells]] and epithelioil cells | ||
|- | |- | ||
! style="background: #DCDCDC; text-align: center;" |Necrotic | ! style="background: #DCDCDC; text-align: center;" |Necrotic | ||
| Line 45: | Line 45: | ||
* uncommon | * uncommon | ||
* Necrotic | *[[Necrotic]] [[tumor]] with unidentifiable [[cell]] type | ||
|} | |} | ||
Uveal melanoma may also be classified according to its location into 2 types: | [[Uvea (anatomy)|Uveal]] [[melanoma]] may also be classified according to its location into 2 types: | ||
* Anterior uveal melanoma | * Anterior [[Uvea (anatomy)|uveal]] [[melanoma]] | ||
** Iris melanoma | **[[Iris]] [[melanoma]] | ||
* Posterior uveal melanoma | * Posterior [[Uvea (anatomy)|uveal]] [[melanoma]] | ||
** Ciliary body melanoma | **[[Ciliary body]] [[melanoma]] | ||
** Chroidal melanoma | ** Chroidal [[melanoma]] | ||
[[File:Untitledd.png|500px|none|thumb|source: {{Fs}}]] | [[File:Untitledd.png|500px|none|thumb|source: {{Fs}}]] | ||
Latest revision as of 17:11, 1 July 2019
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Uveal melanoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Uveal melanoma classification On the Web |
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American Roentgen Ray Society Images of Uveal melanoma classification |
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Risk calculators and risk factors for Uveal melanoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D., Simrat Sarai, M.D. [2]
Overview
Uveal melanoma may be classified according to cell type into 5 subtypes: Spindle A, spindle B, epitheliolid, mixed, and necrotic. Uveal melanoma may also be classified according to its location into 2 types, anterior uveal melanoma which contain iris melanoma, and posterior uveal melanoma which contains ciliary body melanoma and chroidal melanoma.
Classification
Uveal melanoma may be classified according to cell type into 5 subtypes: Spindle A, spindle B, epitheliolid, mixed, and necrotic.[1]
| Cell type | Explanation |
|---|---|
| Spindle A | |
| Spindle B |
|
| Epithelioid | |
| Mixed |
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| Necrotic |
|
Uveal melanoma may also be classified according to its location into 2 types:
References
- ↑ McLean, Ian W.; Foster, Walter D.; Zimmerman, Lorenz E.; Gamel, John W. (1983). "Modifications of Callender's Classification of Uveal Melanoma at the Armed Forces Institute of Pathology". American Journal of Ophthalmology. 96 (4): 502–509. doi:10.1016/S0002-9394(14)77914-0. ISSN 0002-9394.