Uveal melanoma classification: Difference between revisions
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*Medium (10 to 15 mm in diameter and 3 to 5 mm in height) | *Medium (10 to 15 mm in diameter and 3 to 5 mm in height) | ||
*Large (>15 mm in diameter and >5 mm in height) | *Large (>15 mm in diameter and >5 mm in height) | ||
===Classification based on cell type=== | |||
Uveal melanomas originate from melanocytes in the uveal tract. According to the revised Callender classification there are four distinct cellular types.<ref name="NCI">Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq#section/_95 Accessed on October 20 2015</ref> | Uveal melanomas originate from melanocytes in the uveal tract. According to the revised Callender classification there are four distinct cellular types.<ref name="NCI">Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq#section/_95 Accessed on October 20 2015</ref> | ||
*Spindle-A cells (spindle-shaped cells with slender nuclei and lacking visible nucleoli). | *Spindle-A cells (spindle-shaped cells with slender nuclei and lacking visible nucleoli). | ||
Revision as of 07:01, 25 October 2015
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Uveal melanoma classification On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Uveal melanoma may be classified into several subtypes based on their location and based on the cell type. According to the Callender classification, there are four subtypes of uveal melanoma based on the cell type. Based on their location uveal melanoma may be classified into two subtypes.
Classification
Uveal melanomas may arise from any of the three parts of the uvea, and can be divided into two categories.[1]
- Anterior uveal melanomas
- The tumor arises in the iris
- Posterior uveal melanomas
- The tumor arises in either the choroid or the ciliary body. Intraocular melanomas simultaneously can involve more than 1 uveal structure.
Classification based on size
Based on size choroidal melanomas are classified as following:[2][3]
- Small (<10 mm in diameter and <3 mm in height)
- Medium (10 to 15 mm in diameter and 3 to 5 mm in height)
- Large (>15 mm in diameter and >5 mm in height)
Classification based on cell type
Uveal melanomas originate from melanocytes in the uveal tract. According to the revised Callender classification there are four distinct cellular types.[4]
- Spindle-A cells (spindle-shaped cells with slender nuclei and lacking visible nucleoli).
- Spindle-B cells (spindle-shaped cells with larger nuclei and distinct nucleoli).
- Epithelioid cells (larger polygonal cells with one or more prominent nucleoli).
- Intermediate cells (similar to but smaller than epithelioid cells).
Most primary intraocular melanomas contain variable proportions of epithelioid, spindle-A, and spindle-B cells (mixed-cell melanomas). Pure epithelioid-cell primary melanomas are infrequent (approximately 3% of cases). In the Collaborative Ocular Melanoma Study, mixed-cell type melanomas predominated (86% of cases).
References
- ↑ Uveal melanoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Uveal_melanoma Accessed on October 20, 2015
- ↑ Zimmerman LE, McLean IW, Foster WD (1980). "Statistical analysis of follow-up data concerning uveal melanomas, and the influence of enucleation". Ophthalmology. 87 (6): 557–64. PMID 7413145.
- ↑ Shields JA, Shields CL (2015). "Management of posterior uveal melanoma: past, present, and future: the 2014 Charles L. Schepens lecture". Ophthalmology. 122 (2): 414–28. doi:10.1016/j.ophtha.2014.08.046. PMID 25439609.
- ↑ Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq#section/_95 Accessed on October 20 2015