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{{Uveal melanoma}}
{{Uveal melanoma}}
{{CMG}}{{AE}}{{Simrat}}
{{CMG}}{{AE}} {{Fs}}, {{Simrat}}
==Overview==
==Overview==
Uveal melanoma may be classified according to Callender classification into four subtypes based on cell type.
[[Uvea (anatomy)|Uveal]] [[melanoma]] may be classified according to [[Cell (biology)|cell]] type into 5 subtypes: [[Spindle cells|Spindle]] A, [[Spindle cells|spindle]] B, epitheliolid, mixed, and [[necrotic]]. [[Uvea (anatomy)|Uveal]] [[melanoma]] may also be classified according to its location into 2 types, anterior [[Uvea (anatomy)|uveal]] [[melanoma]] which contain [[iris]] [[melanoma]], and posterior [[Uvea (anatomy)|uveal]] [[melanoma]] which contains [[ciliary body]] [[melanoma]] and chroidal [[melanoma]].
 
==Classification==
==Classification==
Uveal melanomas originate from melanocytes in the uveal tract. According to the revised Callender classification there are four distinct cellular types.
[[Uvea (anatomy)|Uveal]] [[melanoma]] may be classified according to [[Cell (biology)|cell]] type into 5 subtypes: [[Spindle cells|Spindle]] A, [[Spindle cells|spindle]] B, epitheliolid, mixed, and [[necrotic]].<ref name="McLeanFoster1983">{{cite journal|last1=McLean|first1=Ian W.|last2=Foster|first2=Walter D.|last3=Zimmerman|first3=Lorenz E.|last4=Gamel|first4=John W.|title=Modifications of Callender's Classification of Uveal Melanoma at the Armed Forces Institute of Pathology|journal=American Journal of Ophthalmology|volume=96|issue=4|year=1983|pages=502–509|issn=00029394|doi=10.1016/S0002-9394(14)77914-0}}</ref>
*Spindle-A cells (spindle-shaped cells with slender nuclei and lacking visible nucleoli).
 
*Spindle-B cells (spindle-shaped cells with larger nuclei and distinct nucleoli).
{|
*Epithelioid cells (larger polygonal cells with one or more prominent nucleoli).
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Cell type
*Intermediate cells (similar to but smaller than epithelioid cells).
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Explanation
Most primary intraocular melanomas contain variable proportions of epithelioid, spindle-A, and spindle-B cells (mixed-cell melanomas). Pure epithelioid-cell primary melanomas are infrequent (approximately 3% of cases). In the Collaborative Ocular Melanoma Study, mixed-cell type melanomas predominated (86% of cases).
|-
! style="background: #DCDCDC; text-align: center;" |Spindle A
| style="background: #F5F5F5;" |
* Fine [[nuclear]] [[chromatin]]
 
*[[Cell (biology)|Cells]] with small spindle nuclei and central dark stripe
* No distinct [[nucleoli]]
* Rare [[mitotic]] features
|-
! style="background: #DCDCDC; text-align: center;" |Spindle B
| style="background: #F5F5F5;" |
* Commen
 
* Coarse [[nuclear]] [[chromatin]]
* Distinct [[nucleoli]]
* Rare [[mitotic]] features
 
|-
! style="background: #DCDCDC; text-align: center;" |Epithelioid
| style="background: #F5F5F5;" |
* Rarest
* Large round [[nuclei]]
* Prominent [[nucleoli]]
*[[Mitotic]] features are common
|-
! style="background: #DCDCDC; text-align: center;" |Mixed
| style="background: #F5F5F5;" |
* Most common
* Contains both [[spindle cells]] and epithelioil cells
|-
! style="background: #DCDCDC; text-align: center;" |Necrotic
| style="background: #F5F5F5;" |
* uncommon
 
*[[Necrotic]] [[tumor]] with unidentifiable [[cell]] type
|}
 
[[Uvea (anatomy)|Uveal]] [[melanoma]] may also be classified according to its location into 2 types:
* Anterior [[Uvea (anatomy)|uveal]] [[melanoma]]
**[[Iris]] [[melanoma]]
* Posterior [[Uvea (anatomy)|uveal]] [[melanoma]]
**[[Ciliary body]]  [[melanoma]]
** Chroidal [[melanoma]]
 
[[File:Untitledd.png|500px|none|thumb|source: {{Fs}}]]
 
== References ==  
== References ==  
{{Reflist|2}}
{{reflist|2}}
{{WH}}
{{WS}}
 
[[Category:Disease]]
[[Category:Ophthalmology]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Ophthalmology]]

Latest revision as of 17:11, 1 July 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D., Simrat Sarai, M.D. [2]

Overview

Uveal melanoma may be classified according to cell type into 5 subtypes: Spindle A, spindle B, epitheliolid, mixed, and necrotic. Uveal melanoma may also be classified according to its location into 2 types, anterior uveal melanoma which contain iris melanoma, and posterior uveal melanoma which contains ciliary body melanoma and chroidal melanoma.

Classification

Uveal melanoma may be classified according to cell type into 5 subtypes: Spindle A, spindle B, epitheliolid, mixed, and necrotic.[1]

Cell type Explanation
Spindle A
Spindle B
  • Commen
Epithelioid
Mixed
Necrotic
  • uncommon

Uveal melanoma may also be classified according to its location into 2 types:

source: Fahimeh Shojaei, M.D.

References

  1. ↑ McLean, Ian W.; Foster, Walter D.; Zimmerman, Lorenz E.; Gamel, John W. (1983). "Modifications of Callender's Classification of Uveal Melanoma at the Armed Forces Institute of Pathology". American Journal of Ophthalmology. 96 (4): 502–509. doi:10.1016/S0002-9394(14)77914-0. ISSN 0002-9394.

Template:WH Template:WS

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