Ulcerative colitis medical therapy: Difference between revisions

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{{MedCondContrAbs
{{MedCondContrAbs


|MedCond = Ulcerative colitis|Alosetron|Dicyclomine|Hyoscyamine|Loperamide|Reserpine|Streptokinase}}
|MedCond = Ulcerative colitis|Alosetron|Dicyclomine|Glycopyrrolate|Hyoscyamine|Loperamide|Reserpine|Streptokinase}}


== References ==
== References ==

Revision as of 14:20, 17 April 2015

Ulcerative colitis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Ulcerative colitis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Abdominal X Ray

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Alternative Treatments

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Medical Therapy

Standard treatment for ulcerative colitis depends on extent of involvement and disease severity. The goal is to induce remission initially with medications, followed by the administration of maintenance medications to prevent a relapse of the disease. The concept of induction of remission and maintenance of remission is very important. The medications used to induce and maintain a remission somewhat overlap, but the treatments are different. Physicians first direct treatment to inducing a remission which involves relief of symptoms and mucosal healing of the lining of the colon and then longer term treatment to maintain the remission.

Pharmacotherapies

Aminosalicylates

Sulfasalazine has been a major agent in the therapy of mild to moderate UC for over 50 years. In 1977 Mastan S.Kalsi et al determined that 5-aminosalicyclic acid (5-ASA and mesalazine) was the therapeutically active compound in sulfasalazine. Since then many 5-ASA compounds have been developed with the aim of maintaining efficacy but reducing the common side effects associated with the sulfapyridine moiety in sulfasalazine.[1]

Corticosteroids

Immunosuppressive drugs

Biological treatment

Contraindicated medications

Ulcerative colitis is considered an absolute contraindication to the use of the following medications:

References

  1. S. Kane (2006). "Asacol - A Review Focusing on Ulcerative Colitis".

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