USP9Y

Ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila)
Identifiers
Symbols	USP9Y ; SP3; AZF; AZFA; DFFRY
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68408
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE USP9Y 206624 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila), also known as USP9Y, is a human gene.

This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mutations in this gene have been associated with Sertoli cell-only (SCO) syndrome and male infertility.

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. PMID 9827704.
• Mesco ER, Timiras PS (1992). "Tau-ubiquitin protein conjugates in a human cell line". Mech. Ageing Dev. 61 (1): 1–9. PMID 1723470.
• Vogt PH, Edelmann A, Kirsch S; et al. (1997). "Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11". Hum. Mol. Genet. 5 (7): 933–43. PMID 8817327.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jones MH, Furlong RA, Burkin H; et al. (1997). "The Drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2". Hum. Mol. Genet. 5 (11): 1695–701. PMID 8922996.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lahn BT, Page DC (1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. PMID 9381176.
• Brown GM, Furlong RA, Sargent CA; et al. (1998). "Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene". Hum. Mol. Genet. 7 (1): 97–107. PMID 9384609.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
• Sun C, Skaletsky H, Birren B; et al. (1999). "An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y". Nat. Genet. 23 (4): 429–32. doi:10.1038/70539. PMID 10581029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Foresta C, Ferlin A, Moro E (2000). "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Hum. Mol. Genet. 9 (8): 1161–9. PMID 10767340.CS1 maint: Multiple names: authors list (link)
• Friel A, Houghton JA, Glennon M; et al. (2002). "A preliminary report on the implication of RT-PCR detection of DAZ, RBMY1, USP9Y and Protamine-2 mRNA in testicular biopsy samples from azoospermic men". Int. J. Androl. 25 (1): 59–64. PMID 11869379.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ioulianos A, Sismani C, Fourouclas N; et al. (2002). "A nation-based population screening for azoospermia factor deletions in Greek-Cypriot patients with severe spermatogenic failure and normal fertile controls, using a specific study and experimental design". Int. J. Androl. 25 (3): 153–8. PMID 12031043.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dada R, Gupta NP, Kucheria K (2003). "Cryptorchidism and AZF microdeletion". Asian J. Androl. 4 (2): 148. PMID 12085107.CS1 maint: Multiple names: authors list (link)
• Dada R, Gupta NP, Kucheria K (2003). "AZF microdeletions associated with idiopathic and non-idiopathic cases with cryptorchidism and varicocele". Asian J. Androl. 4 (4): 259–63. PMID 12508125.CS1 maint: Multiple names: authors list (link)
• Richard SM, Knuutila S, Peltomäki P; et al. (2003). "Y chromosome instability in lymphoproliferative disorders". Mutat. Res. 525 (1–2): 103–7. PMID 12650910.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Raicu F, Popa L, Apostol P; et al. (2003). "Screening for microdeletions in human Y chromosome--AZF candidate genes and male infertility". J. Cell. Mol. Med. 7 (1): 43–8. PMID 12767260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ; et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hopps CV, Mielnik A, Goldstein M; et al. (2004). "Detection of sperm in men with Y chromosome microdeletions of the AZFa, AZFb and AZFc regions". Hum. Reprod. 18 (8): 1660–5. PMID 12871878.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee KH, Song GJ, Kang IS; et al. (2005). "Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome". Reprod. Fertil. Dev. 15 (1–2): 129–33. PMID 12895410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frydelund-Larsen L, Vogt PH, Leffers H; et al. (2004). "No AZF deletion in 160 patients with testicular germ cell neoplasia". Mol. Hum. Reprod. 9 (9): 517–21. PMID 12900510.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)