UBE2C: Difference between revisions

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'''Ubiquitin-conjugating enzyme E2 C''' is a [[protein]] that in humans is encoded by the ''UBE2C'' [[gene]].<ref name="pmid9122200">{{cite journal | vauthors = Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV | title = Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 6 | pages = 2362–7 |date=Apr 1997 | pmid = 9122200 | pmc = 20093 | doi =10.1073/pnas.94.6.2362 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11065| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_UBE2C_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1i7k.
| PDB = {{PDB2|1i7k}}
| Name = Ubiquitin-conjugating enzyme E2C
| HGNCid = 15937
| Symbol = UBE2C
| AltSymbols =; UBCH10; dJ447F3.2
| OMIM = 605574
| ECnumber = 
| Homologene = 5096
| MGIid = 1915862
| GeneAtlas_image1 = PBB_GE_UBE2C_202954_at_tn.png
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007051 |text = spindle organization and biogenesis}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0008054 |text = cyclin catabolic process}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}} {{GNF_GO|id=GO:0031536 |text = positive regulation of exit from mitosis}} {{GNF_GO|id=GO:0048015 |text = phosphoinositide-mediated signaling}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11065
    | Hs_Ensembl = ENSG00000175063
    | Hs_RefseqProtein = NP_008950
    | Hs_RefseqmRNA = NM_007019
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 43874662
    | Hs_GenLoc_end = 43879003
    | Hs_Uniprot = O00762
    | Mm_EntrezGene = 68612
    | Mm_Ensembl = ENSMUSG00000001403
    | Mm_RefseqmRNA = NM_026785
    | Mm_RefseqProtein = NP_081061
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 164461134
    | Mm_GenLoc_end = 164470025
    | Mm_Uniprot = Q3UWQ1
  }}
}}
'''Ubiquitin-conjugating enzyme E2C''', also known as '''UBE2C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11065| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.<ref name="entrez">{{cite web | title = Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11065| accessdate = }}</ref>
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Townsley FM, Aristarkhov A, Beck S, ''et al.'' |title=Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2362-7 |year= 1997 |pmid= 9122200 |doi=  }}
*{{cite journal   |vauthors=Fossey SC, Mychaleckyj JC, Pendleton JK, etal |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 |journal=Genomics |volume=76 |issue= 1–3 |pages= 45–57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584 }}
*{{cite journal  | author=Fossey SC, Mychaleckyj JC, Pendleton JK, ''et al.'' |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. |journal=Genomics |volume=76 |issue= 1-3 |pages= 45-57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584 }}
*{{cite journal   |vauthors=Tang Z, Li B, Bharadwaj R, etal |title=APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex |journal=Mol. Biol. Cell |volume=12 |issue= 12 |pages= 3839–51 |year= 2002 |pmid= 11739784 |doi= 10.1091/mbc.12.12.3839| pmc=60759 }}
*{{cite journal | author=Tang Z, Li B, Bharadwaj R, ''et al.'' |title=APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. |journal=Mol. Biol. Cell |volume=12 |issue= 12 |pages= 3839-51 |year= 2002 |pmid= 11739784 |doi=  }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | vauthors=Lin Y, Hwang WC, Basavappa R |title=Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10 |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21913–21 |year= 2002 |pmid= 11927573 |doi= 10.1074/jbc.M109398200 }}
*{{cite journal  | author=Lin Y, Hwang WC, Basavappa R |title=Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21913-21 |year= 2002 |pmid= 11927573 |doi= 10.1074/jbc.M109398200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Okamoto Y, Ozaki T, Miyazaki K, etal |title=UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme |journal=Cancer Res. |volume=63 |issue= 14 |pages= 4167–73 |year= 2003 |pmid= 12874022 |doi=  }}
*{{cite journal | author=Okamoto Y, Ozaki T, Miyazaki K, ''et al.'' |title=UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme. |journal=Cancer Res. |volume=63 |issue= 14 |pages= 4167-73 |year= 2003 |pmid= 12874022 |doi=  }}
*{{cite journal  | vauthors=Chuang TH, Ulevitch RJ |title=Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors |journal=Nat. Immunol. |volume=5 |issue= 5 |pages= 495–502 |year= 2004 |pmid= 15107846 |doi= 10.1038/ni1066 }}
*{{cite journal  | author=Chuang TH, Ulevitch RJ |title=Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. |journal=Nat. Immunol. |volume=5 |issue= 5 |pages= 495-502 |year= 2004 |pmid= 15107846 |doi= 10.1038/ni1066 }}
*{{cite journal   |vauthors=Wagner KW, Sapinoso LM, El-Rifai W, etal |title=Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin |journal=Oncogene |volume=23 |issue= 39 |pages= 6621–9 |year= 2004 |pmid= 15208666 |doi= 10.1038/sj.onc.1207861 }}
*{{cite journal | author=Wagner KW, Sapinoso LM, El-Rifai W, ''et al.'' |title=Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin. |journal=Oncogene |volume=23 |issue= 39 |pages= 6621-9 |year= 2004 |pmid= 15208666 |doi= 10.1038/sj.onc.1207861 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Le XF, Lammayot A, Gold D, etal |title=Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling |journal=J. Biol. Chem. |volume=280 |issue= 3 |pages= 2092–104 |year= 2005 |pmid= 15504738 |doi= 10.1074/jbc.M403080200 }}
*{{cite journal | author=Le XF, Lammayot A, Gold D, ''et al.'' |title=Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. |journal=J. Biol. Chem. |volume=280 |issue= 3 |pages= 2092-104 |year= 2005 |pmid= 15504738 |doi= 10.1074/jbc.M403080200 }}
*{{cite journal   |vauthors=Pallante P, Berlingieri MT, Troncone G, etal |title=UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas |journal=Br. J. Cancer |volume=93 |issue= 4 |pages= 464–71 |year= 2005 |pmid= 16106252 |doi= 10.1038/sj.bjc.6602721 | pmc=2361574 }}
*{{cite journal | author=Pallante P, Berlingieri MT, Troncone G, ''et al.'' |title=UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas. |journal=Br. J. Cancer |volume=93 |issue= 4 |pages= 464-71 |year= 2005 |pmid= 16106252 |doi= 10.1038/sj.bjc.6602721 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Takahashi Y, Ishii Y, Nishida Y, etal |title=Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH |journal=Cancer Genet. Cytogenet. |volume=168 |issue= 1 |pages= 30–5 |year= 2006 |pmid= 16772118 |doi= 10.1016/j.cancergencyto.2005.12.011 }}
*{{cite journal | author=Takahashi Y, Ishii Y, Nishida Y, ''et al.'' |title=Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH. |journal=Cancer Genet. Cytogenet. |volume=168 |issue= 1 |pages= 30-5 |year= 2006 |pmid= 16772118 |doi= 10.1016/j.cancergencyto.2005.12.011 }}
*{{cite journal   |vauthors=Lin J, Raoof DA, Wang Z, etal |title=Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma |journal=Neoplasia |volume=8 |issue= 12 |pages= 1062–71 |year= 2007 |pmid= 17217624 |doi= 10.1593/neo.05832 | pmc=1783715 }}
*{{cite journal | author=Lin J, Raoof DA, Wang Z, ''et al.'' |title=Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma. |journal=Neoplasia |volume=8 |issue= 12 |pages= 1062-71 |year= 2007 |pmid= 17217624 |doi= 10.1593/neo.05832 }}
*{{cite journal   |vauthors=Ieta K, Ojima E, Tanaka F, etal |title=Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression |journal=Int. J. Cancer |volume=121 |issue= 1 |pages= 33–8 |year= 2007 |pmid= 17354233 |doi= 10.1002/ijc.22605 }}
*{{cite journal | author=Ieta K, Ojima E, Tanaka F, ''et al.'' |title=Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. |journal=Int. J. Cancer |volume=121 |issue= 1 |pages= 33-8 |year= 2007 |pmid= 17354233 |doi= 10.1002/ijc.22605 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=11065}}
{{Ubiquitin-conjugating enzymes}}
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Revision as of 09:31, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[2]

References

  1. ↑ Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV (Apr 1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase". Proc Natl Acad Sci U S A. 94 (6): 2362–7. doi:10.1073/pnas.94.6.2362. PMC 20093. PMID 9122200.
  2. ↑ 2.0 2.1 "Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C".

Further reading



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