UBE2C: Difference between revisions

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'''Ubiquitin-conjugating enzyme E2 C''' is a [[protein]] that in humans is encoded by the ''UBE2C'' [[gene]].<ref name="pmid9122200">{{cite journal | vauthors = Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV | title = Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 6 | pages = 2362–7 |date=Apr 1997 | pmid = 9122200 | pmc = 20093 | doi =10.1073/pnas.94.6.2362  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11065| accessdate = }}</ref>
'''Ubiquitin-conjugating enzyme E2 C''' is a [[protein]] that in humans is encoded by the ''UBE2C'' [[gene]].<ref name="pmid9122200">{{cite journal | vauthors = Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV | title = Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 6 | pages = 2362–7 |date=Apr 1997 | pmid = 9122200 | pmc = 20093 | doi =10.1073/pnas.94.6.2362  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11065| accessdate = }}</ref>
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{{PBB_Summary
{{PBB_Summary
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| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.<ref name="entrez" />
| summary_text = The modification of proteins with [[ubiquitin]] is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of [[enzymes]]: [[ubiquitin-activating enzyme|ubiquitin-activating enzymes]], or E1s, [[ubiquitin-conjugating enzyme|ubiquitin-conjugating enzymes]], or E2s, and [[ubiquitin-protein ligases]], or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic [[cyclins]] and for [[cell cycle progression]]. Multiple [[alternatively spliced]] transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.<ref name="entrez" />
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Latest revision as of 07:18, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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n/a

RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[2]

References

  1. Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV (Apr 1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase". Proc Natl Acad Sci U S A. 94 (6): 2362–7. doi:10.1073/pnas.94.6.2362. PMC 20093. PMID 9122200.
  2. 2.0 2.1 "Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C".

Further reading