Trefoil factor 1: Difference between revisions

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*{{cite journal |vauthors=Takahashi H, Kida N, Fujii R, Tanaka K, Ohta M, Mori K, Hayashi K | title = Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma. | journal = FEBS Lett. | volume = 261 | issue = 2 | pages = 283–6 | year = 1990 | pmid = 2311759 | doi = 10.1016/0014-5793(90)80572-Z }}
*{{cite journal |vauthors=Takahashi H, Kida N, Fujii R, Tanaka K, Ohta M, Mori K, Hayashi K | title = Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma. | journal = FEBS Lett. | volume = 261 | issue = 2 | pages = 283–6 | year = 1990 | pmid = 2311759 | doi = 10.1016/0014-5793(90)80572-Z }}
*{{cite journal |vauthors=Rio MC, Bellocq JP, Daniel JY, Tomasetto C, Lathe R, Chenard MP, Batzenschlager A, Chambon P | title = Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. | journal = Science | volume = 241 | issue = 4866 | pages = 705–8 | year = 1988 | pmid = 3041593 | doi = 10.1126/science.3041593 }}
*{{cite journal |vauthors=Rio MC, Bellocq JP, Daniel JY, Tomasetto C, Lathe R, Chenard MP, Batzenschlager A, Chambon P | title = Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. | journal = Science | volume = 241 | issue = 4866 | pages = 705–8 | year = 1988 | pmid = 3041593 | doi = 10.1126/science.3041593 }}
*{{cite journal |vauthors=Rio MC, Lepage P, Diemunsch P, Roitsch C, Chambon P | title = [Primary structure of human protein pS2] | journal = C. R. Acad. Sci. III, Sci. Vie | volume = 307 | issue = 19 | pages = 825–31 | year = 1989 | pmid = 3146413 | doi =  }}
*{{cite journal |vauthors=Rio MC, Lepage P, Diemunsch P, Roitsch C, Chambon P | title = [Primary structure of human protein pS2] | journal = Comptes Rendus de l'Académie des Sciences, Série III | volume = 307 | issue = 19 | pages = 825–31 | year = 1989 | pmid = 3146413 | doi =  }}
*{{cite journal |vauthors=Mori K, Fujii R, Kida N, Ohta M, Hayashi K | title = Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product. | journal = Biochem. Biophys. Res. Commun. | volume = 155 | issue = 1 | pages = 366–72 | year = 1988 | pmid = 3261981 | doi = 10.1016/S0006-291X(88)81094-5 }}
*{{cite journal |vauthors=Mori K, Fujii R, Kida N, Ohta M, Hayashi K | title = Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product. | journal = Biochem. Biophys. Res. Commun. | volume = 155 | issue = 1 | pages = 366–72 | year = 1988 | pmid = 3261981 | doi = 10.1016/S0006-291X(88)81094-5 }}
*{{cite journal |vauthors=Jeltsch JM, Roberts M, Schatz C, Garnier JM, Brown AM, Chambon P | title = Structure of the human oestrogen-responsive gene pS2. | journal = Nucleic Acids Res. | volume = 15 | issue = 4 | pages = 1401–14 | year = 1987 | pmid = 3822834 | pmc = 340557 | doi = 10.1093/nar/15.4.1401 }}
*{{cite journal |vauthors=Jeltsch JM, Roberts M, Schatz C, Garnier JM, Brown AM, Chambon P | title = Structure of the human oestrogen-responsive gene pS2. | journal = Nucleic Acids Res. | volume = 15 | issue = 4 | pages = 1401–14 | year = 1987 | pmid = 3822834 | pmc = 340557 | doi = 10.1093/nar/15.4.1401 }}

Revision as of 03:54, 6 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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RefSeq (protein)

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Wikidata
View/Edit Human

Trefoil factor 1 is a protein that in humans is encoded by the TFF1 gene[1][2] (also called pS2 gene[3]).

Function

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.[2]

In gastric carcinoma

TFF1 expression is frequently lost in gastric carcinoma, probably through mechanism of DNA methylation, and it is therefore considered as a tumor suppressor gene.[4]

References

  1. ↑ Gött P, Beck S, Machado JC, Carneiro F, Schmitt H, Blin N (May 1997). "Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression". Eur J Hum Genet. 4 (6): 308–15. PMID 9043862.
  2. ↑ 2.0 2.1 "Entrez Gene: TFF1 trefoil factor 1".
  3. ↑ Chatagnon A, Ballestar E, Esteller M, Dante R (2010). "A Role for Methyl-CpG Binding Domain Protein 2 in the Modulation of the Estrogen Response of pS2/TFF1 Gene". PLoS ONE. 5 (3): e9665. doi:10.1371/journal.pone.0009665. PMC 2837351. PMID 20300195.
  4. ↑ Feng G, Zhang Y, Yuan H, Bai R, Zheng J, Zhang J, Song M (Jan 2014). "DNA methylation of trefoil factor 1 (TFF1) is associated with the tumorigenesis of gastric carcinoma". J Mol Med Rep. 9 (1): 109–117. doi:10.3892/mmr.2013.1772. PMID 24190027.

Further reading


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