Transportin 1

Transportin 1
File:PBB Protein TNPO1 image.jpg PDB rendering based on 1qbk.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1qbk​, 2h4m​, 2ot8​
Identifiers
Symbols	TNPO1 ; IPO2; KPNB2; MIP; MIP1; TRN
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5358
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TNPO1 221829 s at tn.png
File:PBB GE TNPO1 207657 x at tn.png
File:PBB GE TNPO1 209225 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Transportin 1, also known as TNPO1, is a human gene.

This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins.

Further reading

• Bukrinsky MI, Haffar OK (2004). "HIV-1 nuclear import: in search of a leader". Front. Biosci. 2: d578–87. PMID 9366553.
• Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr". Mol. Med. 4 (3): 138–43. PMID 9562972.
• Bukrinsky MI, Sharova N, Dempsey MP; et al. (1992). "Active nuclear import of human immunodeficiency virus type 1 preintegration complexes". Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6580–4. PMID 1631159.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moroianu J, Hijikata M, Blobel G, Radu A (1995). "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins". Proc. Natl. Acad. Sci. U.S.A. 92 (14): 6532–6. PMID 7604027.CS1 maint: Multiple names: authors list (link)
• Bukrinsky MI, Haggerty S, Dempsey MP; et al. (1993). "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells". Nature. 365 (6447): 666–9. doi:10.1038/365666a0. PMID 8105392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Michael WM, Choi M, Dreyfuss G (1996). "A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway". Cell. 83 (3): 415–22. PMID 8521471.CS1 maint: Multiple names: authors list (link)
• Pollard VW, Michael WM, Nakielny S; et al. (1996). "A novel receptor-mediated nuclear protein import pathway". Cell. 86 (6): 985–94. PMID 8808633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakielny S, Siomi MC, Siomi H; et al. (1997). "Transportin: nuclear transport receptor of a novel nuclear protein import pathway". Exp. Cell Res. 229 (2): 261–6. doi:10.1006/excr.1996.0369. PMID 8986607.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonifaci N, Moroianu J, Radu A, Blobel G (1997). "Karyopherin beta2 mediates nuclear import of a mRNA binding protein". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5055–60. PMID 9144189.CS1 maint: Multiple names: authors list (link)
• Fridell RA, Truant R, Thorne L; et al. (1997). "Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta". J. Cell. Sci. 110 ( Pt 11): 1325–31. PMID 9202393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gallay P, Hope T, Chin D, Trono D (1997). "HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9825–30. PMID 9275210.CS1 maint: Multiple names: authors list (link)
• Siomi MC, Eder PS, Kataoka N; et al. (1997). "Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins". J. Cell Biol. 138 (6): 1181–92. PMID 9298975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Henderson BR, Percipalle P (1998). "Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta". J. Mol. Biol. 274 (5): 693–707. doi:10.1006/jmbi.1997.1420. PMID 9405152.
• Efthymiadis A, Briggs LJ, Jans DA (1998). "The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties". J. Biol. Chem. 273 (3): 1623–8. PMID 9430704.CS1 maint: Multiple names: authors list (link)
• Vodicka MA, Koepp DM, Silver PA, Emerman M (1998). "HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection". Genes Dev. 12 (2): 175–85. PMID 9436978.CS1 maint: Multiple names: authors list (link)
• Popov S, Rexach M, Zybarth G; et al. (1998). "Viral protein R regulates nuclear import of the HIV-1 pre-integration complex". EMBO J. 17 (4): 909–17. doi:10.1093/emboj/17.4.909. PMID 9463369.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Popov S, Rexach M, Ratner L; et al. (1998). "Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex". J. Biol. Chem. 273 (21): 13347–52. PMID 9582382.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fouchier RA, Meyer BE, Simon JH; et al. (1998). "Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex". J. Virol. 72 (7): 6004–13. PMID 9621063.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)