Transitional cell carcinoma risk factors: Difference between revisions
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:* Jobs that involve manufacture of carpets, paints, plastics, and industrial chemicals. | :* Jobs that involve manufacture of carpets, paints, plastics, and industrial chemicals. | ||
* Chronic [[bladder]] irritation | * Chronic [[bladder]] irritation | ||
* Drinking chlorinated water | |||
* High concentrations of arsenic in drinking water | |||
* Decreased fluid intake | |||
* Consumption of Chinese herbs that contain aristolochic acid | |||
:* [[Inflammation]] | :* [[Inflammation]] | ||
::* Chronic [[urinary tract infection]] | ::* Chronic [[urinary tract infection]] | ||
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* [[Radiation therapy]] | * [[Radiation therapy]] | ||
* [[Arsenic]] | * [[Arsenic]] | ||
* [[Congenital]] bladder anomalies | * [[Congenital]] bladder anomalies | ||
:*[[Urachus]] | :*[[Urachus]] | ||
:*[[Bladder exstrophy|Exstrophy]] | :*[[Bladder exstrophy|Exstrophy]] | ||
* Aristolochic acids | * Aristolochic acids | ||
* Urothelial cancers of the renal pelvis and ureter | |||
* Augmentation cystoplasty | |||
* Thiazolidinediones given for diabetes | |||
* Other factors | |||
:* Air pollution | |||
:* Artificial sweeteners | |||
:* Coffee and tea | |||
:* Hair dyes | |||
* GENETIC EFFECTS | |||
:* Heredity | |||
:* Mutation in the TP53 gene | |||
:* Alterations of the RB gene | |||
:* Differences in the endogenous mechanisms responsible for metabolizing chemical carcinogens | |||
==References== | ==References== | ||
Revision as of 18:10, 18 June 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Common risk factors in the development of transitional cell carcinoma are smoking, occupational exposure to chemicals, chronic bladder irritation, chemotherapy, radiation therapy, arsenic, personal history of cancer in the urinary tract, congenital bladder anomalies, and aristolochic acids.
Risk Factors
Environmental exposures account for most cases of bladder cancer.
Common risk factors in the development of transitional cell carcinoma are:[1][2]
- Smoking 21846855,26149669,
- Smoking tobacco is the strongest risk factor for developing cancer of the renal pelvis or ureter.
- Risk increases with the length of time a person smokes and with the number of cigarettes smoked.
- Exposure to secondhand smoke 17671226
- Phenacetin
- Aromatic amines, such as 2-naphthylamine, benzidine.
- Human papilloma virus
- Balkan nephropathy
- Well-characterized carcinogenic chemicals
- 4-aminobiphenyl,
- 4-nitrobiphenyl,
- 2-amino-1-naphthol
- Occupational exposure to chemicals:14750529,9498898,2407118
- Metal workers,
- Painters
- Rubber industry workers
- Textile and electrical workers
- Miners
- Cement workers
- Transport operators
- Excavating-machine operators
- Jobs that involve manufacture of carpets, paints, plastics, and industrial chemicals.
- Chronic bladder irritation
- Drinking chlorinated water
- High concentrations of arsenic in drinking water
- Decreased fluid intake
- Consumption of Chinese herbs that contain aristolochic acid
-
- Trauma
- Radiation therapy
- Arsenic
- Congenital bladder anomalies
- Aristolochic acids
- Urothelial cancers of the renal pelvis and ureter
- Augmentation cystoplasty
- Thiazolidinediones given for diabetes
- Other factors
- Air pollution
- Artificial sweeteners
- Coffee and tea
- Hair dyes
- GENETIC EFFECTS
- Heredity
- Mutation in the TP53 gene
- Alterations of the RB gene
- Differences in the endogenous mechanisms responsible for metabolizing chemical carcinogens
References
- ↑ Risk factors for bladder cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/renal-pelvis-and-ureter/risks/?region=ab Accessed on February 10, 2016
- ↑ Kirkali, Ziya; Tuzel, Emre (2003). "Transitional cell carcinoma of the ureter and renal pelvis". Critical Reviews in Oncology/Hematology. 47 (2): 155–169. doi:10.1016/S1040-8428(03)00079-9. ISSN 1040-8428.