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{{Toxic shock syndrome}}
{{Toxic shock syndrome}}


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{{CMG}},{{AE}}{{MIR}}


==Overview==
==Overview:==
One of the symptoms of streptococcal toxic shock syndrome is extreme infection of the skin and deeper parts is called [[fasciitis necroticans|necrotizing fasciitis]]. This often requires prompt surgical treatment.
[[Surgery]] is not the first-line treatment option for patients with [[toxic shock syndrome]](TSS). Surgical [[debridement]] is usually reserved for patients with either [[necrotizing fasciitis]](NF), and patients with deep-seeded [[pyogenic]] infection. [[Urgent care|Urgent]] surgical [[debridement]] was recommended for all patients who develop [[Necrotizing fasciitis|NF]] earlier, but is under questioning nowadays.
* Although every medical reference continously announce that early surgical debridement in STSS patients can lead to better management of the disease, there are no enough studies to suggest this idea.
* 9560122


* Prompt, aggressive exploration and debridement of patients thought to have deep-seeded pyogenic infection constitutes a surgical emergency. Surgical exploration through a small incision with visualization of the muscle and fascia may provide an early and definitive diagnosis of necrotizing fasciitis. Infection often is more extensive than is apparent from external examination. Surgical debridement of infected tissue is extremely important and often requires re-exploration to ensure adequacy of resection.
==Surgery==
Prompt, aggressive, immediate exploration and [[debridement]] of patients thought to have deep tissue localized [[infection]] was believed to be a [[surgical emergency]] <ref name="pmid9560122">{{cite journal |vauthors=Schurr M, Engelhardt S, Helgerson R |title=Limb salvage for streptococcal gangrene of the extremity |journal=Am. J. Surg. |volume=175 |issue=3 |pages=213–7 |year=1998 |pmid=9560122 |doi= |url=}}</ref>. Surgical [[exploration]] of the susceptible infected tissue may help with the early and definitive diagnosis of NF. In NF related [[Toxic shock syndrome|TSS]] patients, infection usually is more extensive than is apparent from external examination. Although the necessity of surgical [[debridement]], the recommendation of immediate radical excision of [[necrotic tissue]] in patients with [[Streptococcus|streptococcal]] TSS NF is not supported by clinical studies and should be reconsidered as an emergency treatment in TSS management<ref name="pmid7553574">{{cite journal |vauthors=Kotb M |title=Bacterial pyrogenic exotoxins as superantigens |journal=Clin. Microbiol. Rev. |volume=8 |issue=3 |pages=411–26 |year=1995 |pmid=7553574 |pmc=174633 |doi= |url=}}</ref>.


*
==Indications==
The recommendation of immediate radical excision of necrotic tissue in patients with STSS NF is not supported by clinical studies and should be reconsidered.M. Kotb. Bacterial pyrogenic exotoxins as superantigens. Clin Microbiol Rev, 8 (1995), pp. 411–426
Surgical [[debridement]] of body tissues should be considered in these patients:
 
* [[Localized disease|Localized]] source of [[infection]] is diagnosed
Early and immediate surgical debridement should be considered in most patients with suspected streptococcal toxic shock syndrome (i.e., those who present with fever, pain, soft-tissue swelling, and/or vesicle and bullae formation).
* [[Streptococcus|Streptococcal]] [[Necrotizing fasciitis|NF]]-related [[Toxic shock syndrome|TSS]] patients<ref name="urlChapter 125. Infections of the Skin, Muscles, and Soft Tissues | Harrisons Principles of Internal Medicine, 18e | AccessMedicine | McGraw-Hill Medical">{{cite web |url=http://accessmedicine.mhmedical.com/content.aspx?bookid=331&sectionid=40726869 |title=Chapter 125. Infections of the Skin, Muscles, and Soft Tissues &#124; Harrison's Principles of Internal Medicine, 18e &#124; AccessMedicine &#124; McGraw-Hill Medical |format= |work= |accessdate=}}</ref>
 
Aggressive surgical debridement of infected tissue including fascia is imperative and mandatory if a site of potential infection is identified. Repeated and sequential operative and bedside debridements of infected tissue are often needed, particularly if necrotizing fasciitis is present in streptococcal disease. [null <nowiki>[19]</nowiki>]
 
In addition to surgical debridements, fasciotomy or amputation may be needed to halt the progression of the disease.Stevens DL, Tanner MH, Winship J, et al. Severe group A streptococcal infections associated with a shock-like syndrome. N Engl J Med. 1989;321:1-7


==References==
==References==
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Latest revision as of 00:27, 30 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1],Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]

Overview:

Surgery is not the first-line treatment option for patients with toxic shock syndrome(TSS). Surgical debridement is usually reserved for patients with either necrotizing fasciitis(NF), and patients with deep-seeded pyogenic infection. Urgent surgical debridement was recommended for all patients who develop NF earlier, but is under questioning nowadays.

Surgery

Prompt, aggressive, immediate exploration and debridement of patients thought to have deep tissue localized infection was believed to be a surgical emergency [1]. Surgical exploration of the susceptible infected tissue may help with the early and definitive diagnosis of NF. In NF related TSS patients, infection usually is more extensive than is apparent from external examination. Although the necessity of surgical debridement, the recommendation of immediate radical excision of necrotic tissue in patients with streptococcal TSS NF is not supported by clinical studies and should be reconsidered as an emergency treatment in TSS management[2].

Indications

Surgical debridement of body tissues should be considered in these patients:

References

  1. Schurr M, Engelhardt S, Helgerson R (1998). "Limb salvage for streptococcal gangrene of the extremity". Am. J. Surg. 175 (3): 213–7. PMID 9560122.
  2. Kotb M (1995). "Bacterial pyrogenic exotoxins as superantigens". Clin. Microbiol. Rev. 8 (3): 411–26. PMC 174633. PMID 7553574.
  3. "Chapter 125. Infections of the Skin, Muscles, and Soft Tissues | Harrison's Principles of Internal Medicine, 18e | AccessMedicine | McGraw-Hill Medical".


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