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{{Toxic shock syndrome}}
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== Overview ==
Patients with [[toxic shock syndrome]] (TSS) usually present with [[shock]]. [[Physical examination]] of patients with TSS is usually remarkable for [[hypotension]], [[fever]], and diffuse [[erythroderma]]. The presence of [[desquamation]] on [[physical examination]] is highly suggestive of TSS.


==Physical Examination==
==Physical Examination==
Physical exam in TSS patients usually include these findings:<ref name="urlTintinallis Emergency Medicine: A Comprehensive Study Guide, 8th edition - Judith Tintinalli, J. Stapczynski, O. John Ma, David M. Cline, Garth Meckler - Google Books">{{cite web |url=https://books.google.com/books?id=FNKLCgAAQBAJ&q=It%27s+main+characteristics+involve+diffuse,+red,+macular+rash+resembling+sunburn+that+can+also+involve+the+palms+and+soles.&dq=It%27s+main+characteristics+involve+diffuse,+red,+macular+rash+resembling+sunburn+that+can+also+involve+the+palms+and+soles.&hl=en&sa=X&ved=0ahUKEwjlq-LXoODTAhVF7CYKHQ3aDkoQ6AEIJzAA |title=Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 8th edition - Judith Tintinalli, J. Stapczynski, O. John Ma, David M. Cline, Garth Meckler - Google Books |format= |work= |accessdate=}}</ref><ref name="pmid7282746">{{cite journal |vauthors=Chesney RW, Chesney PJ, Davis JP, Segar WE |title=Renal manifestations of the staphylococcal toxic-shock syndrome |journal=Am. J. Med. |volume=71 |issue=4 |pages=583–8 |year=1981 |pmid=7282746 |doi= |url=}}</ref><ref name="pmid2928649">{{cite journal |vauthors=Olson RD, Stevens DL, Melish ME |title=Direct effects of purified staphylococcal toxic shock syndrome toxin 1 on myocardial function of isolated rabbit atria |journal=Rev. Infect. Dis. |volume=11 Suppl 1 |issue= |pages=S313–5 |year=1989 |pmid=2928649 |doi= |url=}}</ref>
===Appearance of the Patient===
*TSS is presented by its [[shock]] symptoms.
*May be ill appearing in the early stages of the disease, progress to confusion and change in mental status by disease progress.
===Vital Signs===
===Vital Signs===
* [[Hypotension]]: [[systolic blood pressure]] of ≤90 mmHg for adults or less than fifth percentile by age for children <16 years of age, which may be unresponsive to fluid infusion even large amounts of [[isotonic]] [[intravenous fluids]]
* High grade [[Fever]]
* [[Fever]]
* [[Hypotension]]
* [[Tachycardia]] (as a result of shock and hypotension)
**[[Systolic blood pressure]] of ≤90 mmHg for adults or less than fifth percentile by age for children <16 years of age, which may be unresponsive to [[Fluid balance|fluid infusion]] even large amounts of [[isotonic]] [[intravenous fluids]]
* [[Tachypnea]]: may be pressent as a result of pulmonary edema secondary to shock
* [[Tachycardia]]
 
**As a result of [[shock]] and [[hypotension]]
===Neuropsychologic===
* [[Tachypnea]]
* [[Cerebral edema]]  
**May be pressent as a result of [[pulmonary edema]] secondary to [[shock]]
* [[Seizure activity|Seizure]] activity
* [[Headaches]], [[memory loss]],[[disorientation]] and poor [[concentration]] ,
* [[Somnolence]], [[irritability]], [[agitation]], and [[Hallucination|hallucinations]]
* [[Confusion]] without any focal neurological findings


===Gastrointestinal===
===Skin===
* [[Vomiting]]
* Watery [[Diarrhea]]
* [[Hepatic failure|Hepatic Failure]]: Which may present with [[hepatomegaly]], [[hypoalbuminemia]], [[Edema|non-pitting edema]]
 
=== Renal ===
* [[Renal failure|Prerenal failure]]: Decrease in urinary output, due to [[dehydration]] and [[shock]]
* [[Metabolic Control Analysis|Metabolic abnormalities]] related to RF such as [[hypocalcemia]], [[hyponatremia]], and [[hypophosphatemia]] and their related signs and symptoms
 
=== Cardiopulmonary ===
* [[Pleural effusion|Pleural effusions]]
* [[Pulmonary edema]]
* [[Cardiac dysfunction]]
 
===Skin and [[moucosa]]===
* Diffuse [[Pruritic disorders|pruritic]] [[maculopapular]] [[rash]] with palm and soles [[desquamation]]
* Diffuse [[Pruritic disorders|pruritic]] [[maculopapular]] [[rash]] with palm and soles [[desquamation]]
* [[Erythroderma]]
* [[Erythroderma]]
* Superficial [[Ulcer|ulcerations]] that may lead to [[petechiae]], [[vesicles]], and bullae development
* Superficial [[Ulcer|ulcerations]]
* [[Conjunctiva|Conjunctival]]-[[Sclera|scleral hemorrhage]] and [[hyperemia]] of the [[vaginal]] and [[oropharyngeal]] [[mucosa]]
* [[Petechiae]]
* [[Vesicles]]
* Bullae (specially in Streptococcal TSS)
* [[Skin]] [[desquamation]] (apears weeks after disease onset)
* [[Edema|Non-pitting edema]]
* [[Edema|Non-pitting edema]]
* Hair and nail loss<ref name="urlTintinallis Emergency Medicine: A Comprehensive Study Guide, 8th edition - Judith Tintinalli, J. Stapczynski, O. John Ma, David M. Cline, Garth Meckler - Google Books">{{cite web |url=https://books.google.com/books?id=FNKLCgAAQBAJ&q=It%27s+main+characteristics+involve+diffuse,+red,+macular+rash+resembling+sunburn+that+can+also+involve+the+palms+and+soles.&dq=It%27s+main+characteristics+involve+diffuse,+red,+macular+rash+resembling+sunburn+that+can+also+involve+the+palms+and+soles.&hl=en&sa=X&ved=0ahUKEwjlq-LXoODTAhVF7CYKHQ3aDkoQ6AEIJzAA |title=Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 8th edition - Judith Tintinalli, J. Stapczynski, O. John Ma, David M. Cline, Garth Meckler - Google Books |format= |work= |accessdate=}}</ref>,<ref name="pmid7282746">{{cite journal |vauthors=Chesney RW, Chesney PJ, Davis JP, Segar WE |title=Renal manifestations of the staphylococcal toxic-shock syndrome |journal=Am. J. Med. |volume=71 |issue=4 |pages=583–8 |year=1981 |pmid=7282746 |doi= |url=}}</ref>,<ref name="pmid2928649">{{cite journal |vauthors=Olson RD, Stevens DL, Melish ME |title=Direct effects of purified staphylococcal toxic shock syndrome toxin 1 on myocardial function of isolated rabbit atria |journal=Rev. Infect. Dis. |volume=11 Suppl 1 |issue= |pages=S313–5 |year=1989 |pmid=2928649 |doi= |url=}}</ref>.
* Hair and nail loss
 
*[[Cyanosis]]
===HEENT===
*Ophthalmoscopic exam may be abnormal with findings of [[Conjunctiva|conjunctival]]-[[Sclera|scleral hemorrhage]]
*[[Hyperemia]] of [[oropharyngeal]] [[mucosa]]
===Lungs===
*[[Rale|Wet rales]] due to [[pulmonary edema]] complication
===Heart===
*Possibly a [[diastolic]] [[Gallops and Extra Heart Sounds|gallop]] ([[S3]]) due to [[pulmonary edema]]
===Extremities===
*[[Edema|Non-pitting edema]]
**Can develop as a result of increases in [[interstitial fluid]]
 
===Neuromuscular===
*Patient is usually oriented but if the disease is not diagnosed, it can lead to altered [[mental status]] and [[confusion]]
*[[Hyporeflexia]] can be seen as a result of associated [[hypocalcemia]]/ [[hypophosphatemia]]
*[[Muscle cramps|Muscle cramps]] (as a result of [[hypocalcemia]], a contributing complication of [[renal failure]])
*[[Seizure]]
==References==
==References==
{{reflist|2}}
{{reflist|2}}
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[[Category:Needs overview]]
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[[Category:Needs content]]
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Latest revision as of 00:27, 30 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]

Overview

Patients with toxic shock syndrome (TSS) usually present with shock. Physical examination of patients with TSS is usually remarkable for hypotension, fever, and diffuse erythroderma. The presence of desquamation on physical examination is highly suggestive of TSS.

Physical Examination

Physical exam in TSS patients usually include these findings:[1][2][3]

Appearance of the Patient

  • TSS is presented by its shock symptoms.
  • May be ill appearing in the early stages of the disease, progress to confusion and change in mental status by disease progress.

Vital Signs

Skin

HEENT

Lungs

Heart

Extremities

Neuromuscular

References

  1. "Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 8th edition - Judith Tintinalli, J. Stapczynski, O. John Ma, David M. Cline, Garth Meckler - Google Books".
  2. Chesney RW, Chesney PJ, Davis JP, Segar WE (1981). "Renal manifestations of the staphylococcal toxic-shock syndrome". Am. J. Med. 71 (4): 583–8. PMID 7282746.
  3. Olson RD, Stevens DL, Melish ME (1989). "Direct effects of purified staphylococcal toxic shock syndrome toxin 1 on myocardial function of isolated rabbit atria". Rev. Infect. Dis. 11 Suppl 1: S313–5. PMID 2928649.


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