Toxic shock syndrome diagnostic criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]}

Diagnostic Criteria

The diagnosis is dependent upon which organism is responsible for the TSS:

Staphylococcal TSS

The diagnosis of toxic shock syndrome (TSS) is based upon clinical presentation as no confirmatory diagnostic criteria is developed yet. A criteria list have been established by United States Centers for Disease Control and Prevention (CDC) for epidemiologic studies on Staphylococcal TSS, mean that a patient can not be excluded from disease based on the absence of one of these criterias when it come to diagnosis terms:

  1. Gastrointestinal: Vomiting or diarrhea at onset of illness
  2. Muscular: Severe myalgia or creatine phosphokinase elevation >2 times the upper limit of normal
  3. Mucous membranes: Vaginal, oropharyngeal, or conjunctival hyperemia
  4. Renal: Blood urea nitrogen or serum creatinine >2 times the upper limit of normal or pyuria (>5 white blood count/high power field) in the absence of urinary tract infection
  5. Hepatic: Bilirubin or transaminases >2 times the upper limit of normal
  6. Hematologic: Platelets <100,000/microL
  7. Central nervous system: Disorientation or alterations in consciousness without focal neurologic signs in the absence of fever and hypotension
  8. Negative results on the following tests, if obtained: Blood or cerebrospinal fluid cultures for another pathogen (blood cultures may be positive for Staphylococcus aureus){{[1],[2]

References

  1. cite journal |vauthors= |title=Repeat injuries in an inner city population--Philadelphia, 1987-1988 |journal=MMWR Morb. Mortal. Wkly. Rep. |volume=39 |issue=1 |pages=1–3 |year=1990 |pmid=2294395 |doi= |url=}}
  2. "Case definitions for infectious conditions under public health surveillance. Centers for Disease Control and Prevention". MMWR Recomm Rep. 46 (RR-10): 1–55. 1997. PMID 9148133.


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