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| <small>'''''Synonyms / Brand Names:''''' </small>
| | {{Drugbox |
| | | verifiedrevid = 470611261 |
| | | IUPAC_name = ''N''-(2,6-dimethylphenyl)alaninamide |
| | | image = Tocainide.png |
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| {{CMG}} | | <!--Clinical data--> |
| | | tradename = |
| | | Drugs.com = {{drugs.com|CONS|tocainide}} |
| | | MedlinePlus = a601248 |
| | | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
| | | pregnancy_US = <!-- A / B / C / D / X --> |
| | | pregnancy_category = |
| | | legal_AU = <!-- Unscheduled / S2 / S4 / S8 --> |
| | | legal_UK = <!-- GSL / P / POM / CD --> |
| | | legal_US = <!-- OTC / Rx-only --> |
| | | legal_status = |
| | | routes_of_administration = |
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| | <!--Pharmacokinetic data--> |
| | | bioavailability = 0.9-1 (oral) |
| | | protein_bound = 10-20% |
| | | metabolism = glucuronidation (primary) |
| | | elimination_half-life = 9-14 R, 13-20 S |
| | | excretion = 30-50% urine (unchanged) |
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| ==Dosing and Administration==
| | <!--Identifiers--> |
| <br> | | | CASNo_Ref = {{cascite|correct|CAS}} |
| ---- | | | CAS_number_Ref = {{cascite|correct|??}} |
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| | | CAS_number = 41708-72-9 |
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| | | ATC_prefix = C01 |
| [[{{PAGENAME}}#FDA Package Insert Resources|FDA Package Insert Resources]]
| | | ATC_suffix = BB03 |
| <br></font size><small>Indications, Contraindications, Side Effects, Drug Interactions, etc.</small><font size="4"><br>
| | | ATC_supplemental = |
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| | | PubChem = 38945 |
| [http://www.pace-med-apps.com/gfrcalc.htm Calculate Creatine Clearance]
| | | DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
| <br></font size><small>On line calculator of your patients Cr Cl by a variety of formulas.</small><font size="4"><br>
| | | DrugBank = DB01056 |
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| | | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
| [http://home.earthlink.net/~sensei11/convert.htm Convert pounds to Kilograms]
| | | ChemSpiderID = 35632 |
| <br></font size><small>On line calculator of your patients weight in pounds to Kg for dosing estimates.</small><font size="4"><br>
| | | UNII_Ref = {{fdacite|correct|FDA}} |
| <br> [[{{PAGENAME}}#Publication Resources|Publication Resources]]
| | | UNII = 27DXO59SAN |
| <br></font size><small>Recent articles, WikiDoc State of the Art Review, Textbook Information</small><font size="4"><br>
| | | KEGG_Ref = {{keggcite|correct|kegg}} |
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| | | KEGG = D06172 |
| [[{{PAGENAME}}#Trial Resources|Trial Resources]]
| | | ChEBI_Ref = {{ebicite|correct|EBI}} |
| <br></font size><small>Ongoing Trials, Trial Results</small><font size="4"><br>
| | | ChEBI = 9611 |
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| | | ChEMBL_Ref = {{ebicite|correct|EBI}} |
| [[{{PAGENAME}}#Guidelines & Evidence Based Medicine Resources|Guidelines & Evidence Based Medicine Resources]]
| | | ChEMBL = 1762 |
| <br></font size><small>US National Guidelines, Cochrane Collaboration, etc.</small><font size="4"><br>
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| [[{{PAGENAME}}#Media Resources|Media Resources]]
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| [[{{PAGENAME}}#Patient Resources|Patient Resources]]
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| [[{{PAGENAME}}#International Resources|International Resources]]
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| <br></font size><small>en Español</small><font size="4"><br>
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| ==FDA Package Insert Resources== | | <!--Chemical data--> |
| [[{{PAGENAME}} indications|Indications]]
| | | C=11 | H=16 | N=2 | O=1 |
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| | | molecular_weight = 192.258 g/mol |
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| | | smiles = O=C(Nc1c(cccc1C)C)C(N)C |
| [[{{PAGENAME}} contraindications|Contraindications]]
| | | InChI = 1/C11H16N2O/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12/h4-6,9H,12H2,1-3H3,(H,13,14) |
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| | | InChIKey = BUJAGSGYPOAWEI-UHFFFAOYAA |
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| | | StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
| [[{{PAGENAME}} side effects|Side Effects]]
| | | StdInChI = 1S/C11H16N2O/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12/h4-6,9H,12H2,1-3H3,(H,13,14) |
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| | | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| | | StdInChIKey = BUJAGSGYPOAWEI-UHFFFAOYSA-N |
| [[{{PAGENAME}} drug interactions|Drug Interactions]]
| | }} |
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| | __NOTOC__ |
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| [[{{PAGENAME}} precautions|Precautions]]
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| [[{{PAGENAME}} overdose|Overdose]]
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| [[{{PAGENAME}} instructions for administration|Instructions for Administration]]
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| [[{{PAGENAME}} how supplied|How Supplied]]
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| [[{{PAGENAME}} pharmacokinetics and molecular data|Pharmacokinetics and Molecular Data]]
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| [[FDA label]]
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| [http://google2.fda.gov/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&x=0&y=0&client=FDA&site=FDA&lr=&proxystylesheet=FDA&output=xml_no_dtd&getfields=* FDA on {{PAGENAME}}]
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| ==Publication Resources== | | ==Overview== |
| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Most Recent Articles on {{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}] | | '''Tocainide''' (Tonocard) is a class Ib [[antiarrhythmic agent]]. It is no longer sold in the United States. |
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| [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}%20AND%20systematic%5Bsb%5D Review Articles on {{PAGENAME}}]
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| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+AND+%28%28N+Engl+J+Med%5Bta%5D%29+OR+%28Lancet%5Bta%5D%29+OR+%28BMJ%5Bta%5D%29%29 Articles on {{PAGENAME}} in N Eng J Med, Lancet, BMJ]
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| [[WikiDoc state of the art review on {{PAGENAME}}|WikiDoc State of the Art Review]]
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| [http://books.google.com/books?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search&sa=N&tab=gp Textbook Information on {{PAGENAME}}]
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| ==Trial Resources== | | ==Pharmacokinetics== |
| [http://clinicaltrials.gov/search/open/condition={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Ongoing Trials with {{PAGENAME}} at Clinical Trials.gov]
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| ==Guidelines & Evidence Based Medicine Resources==
| | Tocainide is a [[lidocaine]] analog, that does not have significant 1st pass metabolism. It is found in two [[enantiomer]]s. The R isomer is 4x as potent as the S. Oral bioavailability is 0.9-1.0. In the blood tocainide is 10-20% protein bound. The Volume of distribution is 2.5-3.5 L/kg. 30-50% is excreted unchanged in the urine. The more active R-isomer is cleared faster in anephric patients or those with severe renal dysfunction. The main metabolite is the glucuronidated tocainide carbamic acid. The glucuronosyl transferase is apparently induced by rifampin. Weak inhibition of Cyp1A2 leads to a mild theophylline interaction. |
| [http://www.guideline.gov/search/searchresults.aspx?Type=3&txtSearch={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&num=20 US National Guidelines Clearinghouse on {{PAGENAME}}] | |
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| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:({{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}) AND (Cochrane Database Syst Rev[ta])}} Cochrane Collaboration on {{PAGENAME}}]
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| ==Media Resources==
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| [http://www.google.com/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+ppt&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a Powerpoint Slides on {{PAGENAME}}]
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| ==Patient Resources== | | ==References== |
| [[{{PAGENAME}} (patient information)|Patient Information from National Library of Medicine]]
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| [http://www.google.com/search?hl=en&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+more:for_patients&cx=disease_for_patients&sa=N&oi=cooptsr&resnum=0&ct=col3&cd=1 Patient Resources on {{PAGENAME}}]
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| ==International Resources==
| | {{Antiarrhythmic agents}} |
| [http://www.google.com/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+en+espanol&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a {{PAGENAME}} en Español]
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| {{FDA}}
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| [[Category:Drugs]] | | [[Category:Antiarrhythmic agents]] |
| | [[Category:Cardiovascular Drugs]] |
| | [[Category:Drug]] |
