Tirilazad

Tirilazad

Clinical data
Synonyms	(8S,10S,13S,14S,16R,17S)-17-[2-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13,16-trimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
ATC code	N07XX01 (WHO)
Identifiers
IUPAC name (16α)-21-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]-16-methylpregna-1,4,9(11)-triene-3,20-dione
CAS Number	110101-66-1 N
PubChem CID	104903
ChemSpider	94673 Y
UNII	YD064E883I
KEGG	D08606 Y
ChEMBL	ChEMBL1630578 N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C38H52N6O2
Molar mass	624.859 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(CN4CCN(c2nc(nc(N1CCCC1)c2)N3CCCC3)CC4)[C@H]6[C@H](C)C[C@H]5[C@H]8C(=C/C[C@@]56C)\[C@]/7(/C=C\C(=O)\C=C\7CC8)C
InChI InChI=1S/C38H52N6O2/c1-26-22-31-29-9-8-27-23-28(45)10-12-37(27,2)30(29)11-13-38(31,3)35(26)32(46)25-41-18-20-43(21-19-41)34-24-33(42-14-4-5-15-42)39-36(40-34)44-16-6-7-17-44/h10-12,23-24,26,29,31,35H,4-9,13-22,25H2,1-3H3/t26-,29-,31+,35-,37+,38+/m1/s1 Y Key:RBKASMJPSJDQKY-RBFSKHHSSA-N Y
NY (what is this?)  (verify)

Tirilazad is a drug proposed to treat acute ischaemic stroke, however results are mixed as to whether the drug truly treats stroke.

Mixed results

When tested on animal models, tirilazad protects brain tissue, and reduces any brain damage. On the contrary, the drug fails to treat, and even worsens a stroke when studied on a human being.

Usage in treatment of stroke

Tirilazad currently has no usage in the clinical treatment of stroke.

References

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