Tipepidine

Revision as of 16:00, 9 April 2015 by Turky Alkathery (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
Tipepidine
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC15H17NS2
Molar mass275.434 g/mol
3D model (JSmol)
  (verify)

WikiDoc Resources for Tipepidine

Articles

Most recent articles on Tipepidine

Most cited articles on Tipepidine

Review articles on Tipepidine

Articles on Tipepidine in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Tipepidine

Images of Tipepidine

Photos of Tipepidine

Podcasts & MP3s on Tipepidine

Videos on Tipepidine

Evidence Based Medicine

Cochrane Collaboration on Tipepidine

Bandolier on Tipepidine

TRIP on Tipepidine

Clinical Trials

Ongoing Trials on Tipepidine at Clinical Trials.gov

Trial results on Tipepidine

Clinical Trials on Tipepidine at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Tipepidine

NICE Guidance on Tipepidine

NHS PRODIGY Guidance

FDA on Tipepidine

CDC on Tipepidine

Books

Books on Tipepidine

News

Tipepidine in the news

Be alerted to news on Tipepidine

News trends on Tipepidine

Commentary

Blogs on Tipepidine

Definitions

Definitions of Tipepidine

Patient Resources / Community

Patient resources on Tipepidine

Discussion groups on Tipepidine

Patient Handouts on Tipepidine

Directions to Hospitals Treating Tipepidine

Risk calculators and risk factors for Tipepidine

Healthcare Provider Resources

Symptoms of Tipepidine

Causes & Risk Factors for Tipepidine

Diagnostic studies for Tipepidine

Treatment of Tipepidine

Continuing Medical Education (CME)

CME Programs on Tipepidine

International

Tipepidine en Espanol

Tipepidine en Francais

Business

Tipepidine in the Marketplace

Patents on Tipepidine

Experimental / Informatics

List of terms related to Tipepidine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Tipepidine (INN) (brand names Asverin, Antupex, Asvelik, Asvex, Bitiodin, Cofdenin A, Hustel, Nodal, Sotal), also known as tipepidine hibenzate (JAN), is a synthetic, non-opioid antitussive and expectorant of the thiambutene class.[1][2] It acts as an inhibitor of G protein-coupled inwardly-rectifying potassium channels (GIRKs).[3] The drug was discovered in the 1950s,[4] and was developed in Japan in 1959.[5] It is used as the hibenzate and citrate salts.[1][5] The usual dose is 20 mg every 4–6 hours.[citation needed] Possible side effects of tipepidine, especially in overdose, may include drowsiness, vertigo, delirium, disorientation, loss of consciousness, and confusion.[5]

Tipepidine has recently garnered interest as a potential psychiatric drug. It is being investigated in depression,[3][6][7] obsessive-compulsive disorder,[8] and attention-deficit hyperactivity disorder (ADHD).[9][10] Through inhibition of GIRK channels, tipepidine increases dopamine levels in the nucleus accumbens, but without increasing locomotor activity or producing methamphetamine-like behavioral sensitization, and this action appears to be at least partly responsible for its antidepressant-like effects in rodents.[11][12]

See also

References

  1. 1.0 1.1 C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1988–. ISBN 978-0-412-46630-4.
  2. Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 1649–. ISBN 978-3-88763-075-1.
  3. 3.0 3.1 Kawaura, Kazuaki; Ogata, Yukino; Inoue, Masako; Honda, Sokichi; Soeda, Fumio; Shirasaki, Tetsuya; Takahama, Kazuo (2009). "The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats". Behavioural Brain Research. 205 (1): 315–318. doi:10.1016/j.bbr.2009.07.004. ISSN 0166-4328.
  4. ES Patent 272195
  5. 5.0 5.1 5.2 Imai, Yuki; Ishii, Wakako; Endo, Ayumi; Arakawa, Chikako; Kohira, Ryutaro; Fujita, Yukihiko; Fuchigami, Tatsuo; Mugishima, Hideo (2011). "Tipepidine hibenzate intoxication". Pediatrics International. 53 (5): 779–781. doi:10.1111/j.1442-200X.2010.03297.x. ISSN 1328-8067.
  6. KAWAURA, Kazuaki; HONDA, Sokichi; SOEDA, Fumio; SHIRASAKI, Tetsuya; TAKAHAMA, Kazuo (2010). "A Novel Antidepressant-like Action of Drugs Possessing GIRK Channel Blocking Action in Rats". YAKUGAKU ZASSHI. 130 (5): 699–705. doi:10.1248/yakushi.130.699. ISSN 0031-6903.
  7. Sasaki T, Hashimoto K, Tachibana M, Kurata T, Kimura H, Komatsu H, et al. (2014). "Tipepidine in adolescent patients with depression: a 4 week, open-label, preliminary study". Neuropsychiatr Dis Treat. 10: 719–22. doi:10.2147/NDT.S63075. PMC 4015794. PMID 24833905.
  8. Honda, Sokichi; Kawaura, Kazuaki; Soeda, Fumio; Shirasaki, Tetsuya; Takahama, Kazuo (2011). "The potent inhibitory effect of tipepidine on marble-burying behavior in mice". Behavioural Brain Research. 216 (1): 308–312. doi:10.1016/j.bbr.2010.08.010. ISSN 0166-4328.
  9. Sasaki T, Hashimoto K, Tachibana M, Kurata T, Okawada K, Ishikawa M, et al. (2014). "Tipepidine in children with attention deficit/hyperactivity disorder: a 4-week, open-label, preliminary study". Neuropsychiatr Dis Treat. 10: 147–51. doi:10.2147/NDT.S58480. PMC 3908907. PMID 24493927.
  10. Hashimoto, K.; Sasaki, T. (2014). "Old drug tipepidine as new hope for children with ADHD". Australian & New Zealand Journal of Psychiatry. 49 (2): 181–182. doi:10.1177/0004867414553952. ISSN 0004-8674.
  11. Hamasaki R, Shirasaki T, Soeda F, Takahama K (2013). "Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current". Neuroscience. 252: 24–34. doi:10.1016/j.neuroscience.2013.07.044. PMID 23896570.
  12. Hamao K, Kawaura K, Soeda F, Hamasaki R, Shirasaki T, Takahama K (2015). "Tipepidine increases dopamine level in the nucleus accumbens without methamphetamine-like behavioral sensitization". Behav. Brain Res. doi:10.1016/j.bbr.2015.02.012. PMID 25687844.


Template:Cough and cold preparations