Thyroid adenoma overview: Difference between revisions
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==Overview== | ==Overview== | ||
A thyroid adenoma is a benign tumor of the thyroid gland. Thyroid adenoma was first discovered by Fabricious, in 1619 when he described that thyroid enlargement causes mid line neck swelling. Thyroid adenoma may be classified according to histology into 3 subtypes/groups: follicular adenoma, papillary adenoma, and signet cell adenoma. Thyroid adenoma arises from epithelial cells of thyroid gland, that are normally involved in secretion of thyroxine hormone. The most common gene involved in the pathogenesis of thyroid adenoma is ''THADA'' gene. Common causes of thyroid adenoma include iodine deficiency, chronic inflammation, and genetic mutation of ''THADA'' gene. Thyroid adenoma must be differentiated from other thyroid disorders such as [[multinodular goiter, [[grave's disease]], [[Hashimoto's disease]], medullary cell carcinoma, [[De Quervain's thyroiditis]], thyroid lymphoma, and acute suppurative thyroiditis. The incidence of thyroid adenoma is estimated to be 9 million cases annually in United States. Females are more commonly affected with thyroid adenoma than males. Common risk factors in the development of thyroid adenoma are family history, exposure to radiation, lack of iodine in diet, smoking, and Hashimoto’s thyroiditis. Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as excellent. The hallmark of thyroid adenoma is swelling infront of neck. A positive history of radiation exposure and family history of thyroid adenoma is suggestive of thyroid adenoma. The most common symptoms thyroid adenoma include cough and hoarseness of voice. On ultrasound, thyroid adenoma is characterized by halo sign or smooth margin of thyroid, hyperechoic nodules, and normal reactive cervical nodes. Fine needle aspiration biopsy may be helpful in diagnosis of thyroid adenoma. Findings on fine needle aspiration biopsy suggestive of thyroid adenoma include cystic changes, fibrosis, and areas of hemorrhage. The mainstay of therapy for thyroid adenoma is supportive therapy and regular monitoring. | |||
==Historical Perspective== | ==Historical Perspective== | ||
Thyroid adenoma was first discovered by Fabricious, in 1619 when he described that thyroid enlargement causes mid line neck swelling | Thyroid adenoma was first discovered by Fabricious, in 1619 when he described that thyroid enlargement causes mid line neck swelling. | ||
==Classification== | ==Classification== | ||
Thyroid adenoma may be classified according to histology into 3 subtypes/groups: follicular adenoma, papillary adenoma, and signet cell adenoma. | Thyroid adenoma may be classified according to histology into 3 subtypes/groups: follicular adenoma, papillary adenoma, and signet cell adenoma. | ||
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==Differentiating thyroid adenoma from other Conditions== | ==Differentiating thyroid adenoma from other Conditions== | ||
Thyroid adenoma must be differentiated from other thyroid disorders such as [[multinodular goiter, [[grave's disease]], [[Hashimoto's disease]], medullary cell carcinoma, [[De Quervain's thyroiditis]], thyroid lymphoma, and acute suppurative thyroiditis. | Thyroid adenoma must be differentiated from other thyroid disorders such as [[multinodular goiter, [[grave's disease]], [[Hashimoto's disease]], medullary cell carcinoma, [[De Quervain's thyroiditis]], thyroid lymphoma, and acute suppurative thyroiditis. | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
The incidence of thyroid adenoma is estimated to be 9 million cases annually in United States. Females are more commonly affected with thyroid adenoma than males. | The incidence of thyroid adenoma is estimated to be 9 million cases annually in United States. Females are more commonly affected with thyroid adenoma than males. | ||
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Common risk factors in the development of thyroid adenoma are family history, exposure to radiation, lack of iodine in diet, smoking, and Hashimoto’s thyroiditis. | Common risk factors in the development of thyroid adenoma are family history, exposure to radiation, lack of iodine in diet, smoking, and Hashimoto’s thyroiditis. | ||
==Natural History, Complications and Prognosis== | ==Natural History, Complications and Prognosis== | ||
Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as excellent. | Depending on the extent of the tumor at the time of diagnosis, the prognosis of thyroid adenoma may vary. However, the prognosis is generally regarded as excellent. Common complications of thyroid adenoma | ||
include hyperthyroidism, thyrotoxicosis, hemorrhage, thyroid cyst, and superior vena cava obstruction. | |||
==Diagnosis== | ==Diagnosis== | ||
===History and Symptoms=== | ===History and Symptoms=== | ||
The hallmark of thyroid adenoma is swelling infront of neck. A positive history of radiation exposure and family history of thyroid adenoma is | The hallmark of thyroid adenoma is swelling infront of neck. A positive history of radiation exposure and family history of thyroid adenoma is suggestive of thyroid adenoma. The most common symptoms thyroid adenoma include cough and hoarseness of voice. | ||
suggestive of thyroid adenoma. The most common symptoms thyroid adenoma include cough and hoarseness of voice. | |||
===Physical Examination=== | ===Physical Examination=== | ||
Patients with thyroid adenoma usually appear normal. Physical examination of patients with thyroid adenoma is usually remarkable for solitary non tender nodule in the midline of neck, which is smooth, soft, and mobile. | Patients with thyroid adenoma usually appear normal. Physical examination of patients with thyroid adenoma is usually remarkable for solitary non tender nodule in the midline of neck, which is smooth, soft, and mobile. | ||
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===Biopsy=== | ===Biopsy=== | ||
Fine needle aspiration biopsy may be helpful in diagnosis of thyroid adenoma. Findings on fine needle aspiration biopsy suggestive of thyroid adenoma include cystic changes, fibrosis, and areas of hemorrhage. | Fine needle aspiration biopsy may be helpful in diagnosis of thyroid adenoma. Findings on fine needle aspiration biopsy suggestive of thyroid adenoma include cystic changes, fibrosis, and areas of hemorrhage. | ||
==Treatment== | ==Treatment== | ||
===Medical Therapy=== | ===Medical Therapy=== | ||
The mainstay of therapy for thyroid adenoma is supportive therapy and regular monitoring. | The mainstay of therapy for thyroid adenoma is supportive therapy and regular monitoring. | ||
===Surgery=== | ===Surgery=== | ||
Thyroid lobectomy is recommended for all patients who develop pressure symptoms of thyroid adenoma. | Thyroid lobectomy is recommended for all patients who develop pressure symptoms of thyroid adenoma. | ||
===Prevention=== | ===Prevention=== | ||
There is no established method for prevention of thyroid adenoma. | There is no established method for prevention of thyroid adenoma. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 13:21, 12 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
A thyroid adenoma is a benign tumor of the thyroid gland. Thyroid adenoma was first discovered by Fabricious, in 1619 when he described that thyroid enlargement causes mid line neck swelling. Thyroid adenoma may be classified according to histology into 3 subtypes/groups: follicular adenoma, papillary adenoma, and signet cell adenoma. Thyroid adenoma arises from epithelial cells of thyroid gland, that are normally involved in secretion of thyroxine hormone. The most common gene involved in the pathogenesis of thyroid adenoma is THADA gene. Common causes of thyroid adenoma include iodine deficiency, chronic inflammation, and genetic mutation of THADA gene. Thyroid adenoma must be differentiated from other thyroid disorders such as [[multinodular goiter, grave's disease, Hashimoto's disease, medullary cell carcinoma, De Quervain's thyroiditis, thyroid lymphoma, and acute suppurative thyroiditis. The incidence of thyroid adenoma is estimated to be 9 million cases annually in United States. Females are more commonly affected with thyroid adenoma than males. Common risk factors in the development of thyroid adenoma are family history, exposure to radiation, lack of iodine in diet, smoking, and Hashimoto’s thyroiditis. Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as excellent. The hallmark of thyroid adenoma is swelling infront of neck. A positive history of radiation exposure and family history of thyroid adenoma is suggestive of thyroid adenoma. The most common symptoms thyroid adenoma include cough and hoarseness of voice. On ultrasound, thyroid adenoma is characterized by halo sign or smooth margin of thyroid, hyperechoic nodules, and normal reactive cervical nodes. Fine needle aspiration biopsy may be helpful in diagnosis of thyroid adenoma. Findings on fine needle aspiration biopsy suggestive of thyroid adenoma include cystic changes, fibrosis, and areas of hemorrhage. The mainstay of therapy for thyroid adenoma is supportive therapy and regular monitoring.
Historical Perspective
Thyroid adenoma was first discovered by Fabricious, in 1619 when he described that thyroid enlargement causes mid line neck swelling.
Classification
Thyroid adenoma may be classified according to histology into 3 subtypes/groups: follicular adenoma, papillary adenoma, and signet cell adenoma.
Pathophysiology
Thyroid adenoma arises from epithelial cells of thyroid gland, that are normally involved in secretion of thyroxine hormone. The most common gene involved in the pathogenesis of thyroid adenoma is THADA gene.
Causes
Common causes of thyroid adenoma include iodine deficiency, chronic inflammation, and genetic mutation of THADA gene
Differentiating thyroid adenoma from other Conditions
Thyroid adenoma must be differentiated from other thyroid disorders such as [[multinodular goiter, grave's disease, Hashimoto's disease, medullary cell carcinoma, De Quervain's thyroiditis, thyroid lymphoma, and acute suppurative thyroiditis.
Epidemiology and Demographics
The incidence of thyroid adenoma is estimated to be 9 million cases annually in United States. Females are more commonly affected with thyroid adenoma than males.
Risk Factors
Common risk factors in the development of thyroid adenoma are family history, exposure to radiation, lack of iodine in diet, smoking, and Hashimoto’s thyroiditis.
Natural History, Complications and Prognosis
Depending on the extent of the tumor at the time of diagnosis, the prognosis of thyroid adenoma may vary. However, the prognosis is generally regarded as excellent. Common complications of thyroid adenoma include hyperthyroidism, thyrotoxicosis, hemorrhage, thyroid cyst, and superior vena cava obstruction.
Diagnosis
History and Symptoms
The hallmark of thyroid adenoma is swelling infront of neck. A positive history of radiation exposure and family history of thyroid adenoma is suggestive of thyroid adenoma. The most common symptoms thyroid adenoma include cough and hoarseness of voice.
Physical Examination
Patients with thyroid adenoma usually appear normal. Physical examination of patients with thyroid adenoma is usually remarkable for solitary non tender nodule in the midline of neck, which is smooth, soft, and mobile.
Laboratory Findings
Laboratory findings consistent with the diagnosis of thyroid adenoma include decreased thyroid stimulating hormone, elevated calcitonin, and decreased calcium.
Ultrasound
On ultrasound, thyroid adenoma is characterized by halo sign or smooth margin of thyroid, hyperechoic nodules, and normal reactive cervical nodes.
Other Imaging Findings
Other diagnostic studies for thyroid adenoma include thyroid scan, which demonstrates hot, cold, and functioning nodule.
Biopsy
Fine needle aspiration biopsy may be helpful in diagnosis of thyroid adenoma. Findings on fine needle aspiration biopsy suggestive of thyroid adenoma include cystic changes, fibrosis, and areas of hemorrhage.
Treatment
Medical Therapy
The mainstay of therapy for thyroid adenoma is supportive therapy and regular monitoring.
Surgery
Thyroid lobectomy is recommended for all patients who develop pressure symptoms of thyroid adenoma.
Prevention
There is no established method for prevention of thyroid adenoma.