TUB (gene)

Tubby homolog (mouse)
File:PBB Protein TUB image.jpg PDB rendering based on 1c8z.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1c8z​, 1i7e​, 1s31​
Identifiers
Symbols	TUB ; rd5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31147
Gene ontology Cellular component Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TUB 208431 s at tn.png
File:PBB GE TUB 210737 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tubby homolog (mouse), also known as TUB, is a human gene.

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• Ikeda A, Nishina PM, Naggert JK (2002). "The tubby-like proteins, a family with roles in neuronal development and function". J. Cell. Sci. 115 (Pt 1): 9–14. PMID 11801719.CS1 maint: Multiple names: authors list (link)
• Jones JM, Meisler MH, Seldin MF; et al. (1992). "Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7". Genomics. 14 (1): 197–9. PMID 1358794.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kleyn PW, Fan W, Kovats SG; et al. (1996). "Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family". Cell. 85 (2): 281–90. PMID 8612280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• North MA, Naggert JK, Yan Y; et al. (1997). "Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3128–33. PMID 9096357.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kapeller R, Moriarty A, Strauss A; et al. (1999). "Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin". J. Biol. Chem. 274 (35): 24980–6. PMID 10455176.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boggon TJ, Shan WS, Santagata S; et al. (1999). "Implication of tubby proteins as transcription factors by structure-based functional analysis". Science. 286 (5447): 2119–25. PMID 10591637.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• He W, Ikeda S, Bronson RT; et al. (2001). "GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members". Brain Res. Mol. Brain Res. 81 (1–2): 109–17. PMID 11000483.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Santagata S, Boggon TJ, Baird CL; et al. (2001). "G-protein signaling through tubby proteins". Science. 292 (5524): 2041–50. doi:10.1126/science.1061233. PMID 11375483.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV; et al. (2006). "Identification of TUB as a novel candidate gene influencing body weight in humans". Diabetes. 55 (2): 385–9. PMID 16443771.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Giannaccini G, Giusti L, Santini F; et al. (2007). "Tubby protein in human lymphocytes from normal weight and obese subjects". Clin. Biochem. 40 (11): 806–9. doi:10.1016/j.clinbiochem.2007.03.020. PMID 17498679.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)