TUBB2A: Difference between revisions

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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Tubulin beta-2A chain''' is a [[protein]] that in humans is encoded by the ''TUBB2A'' [[gene]].<ref name="pmid14574404">{{cite journal | vauthors = Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S | title = The DNA sequence and analysis of human chromosome 6 | journal = Nature | volume = 425 | issue = 6960 | pages = 805–11 |date=Oct 2003 | pmid = 14574404 | pmc =  | doi = 10.1038/nature02055 }}</ref><ref>{{cite web | title = Entrez Gene: TUBB2A tubulin, beta 2A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7280| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_TUBB2A_image.jpg
| image_source = [[Protein Data Bank|PDB]] rendering based on 1ffx.
| PDB = {{PDB2|1ffx}}, {{PDB2|1ia0}}, {{PDB2|1jff}}, {{PDB2|1sa0}}, {{PDB2|1sa1}}, {{PDB2|1tub}}, {{PDB2|1tvk}}, {{PDB2|1z2b}}, {{PDB2|2hxf}}, {{PDB2|2hxh}}
| Name = Tubulin, beta 2A
| HGNCid = 12412
| Symbol = TUBB2A
| AltSymbols =; TUBB; TUBB2; dJ40E16.7
| OMIM = 
| ECnumber = 
| Homologene = 68156
| MGIid = 107861
| GeneAtlas_image1 = PBB_GE_TUBB2A_202154_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_TUBB2A_208977_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TUBB2A_204141_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0043234 |text = protein complex}}
| Process = {{GNF_GO|id=GO:0007018 |text = microtubule-based movement}} {{GNF_GO|id=GO:0051258 |text = protein polymerization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7280
    | Hs_Ensembl = ENSG00000137267
    | Hs_RefseqProtein = NP_001060
    | Hs_RefseqmRNA = NM_001069
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 3098918
    | Hs_GenLoc_end = 3102808
    | Hs_Uniprot = Q13885
    | Mm_EntrezGene = 22151
    | Mm_Ensembl = ENSMUSG00000058672
    | Mm_RefseqmRNA = NM_009450
    | Mm_RefseqProtein = NP_033476
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 34081743
    | Mm_GenLoc_end = 34085453
    | Mm_Uniprot = Q62363
  }}
}}
'''Tubulin, beta 2A''', also known as '''TUBB2A''', is a human [[gene]].<ref>{{cite web | title = Entrez Gene: TUBB2A tubulin, beta 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7280| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
<references />


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi=  }}
*{{cite journal  | vauthors=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=10.1016/S0163-4453(05)80037-4 }}
*{{cite journal  | author=Horisberger MA |title=Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins. |journal=J. Virol. |volume=66 |issue= 8 |pages= 4705-9 |year= 1992 |pmid= 1629950 |doi=  }}
*{{cite journal  | author=Horisberger MA |title=Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins |journal=J. Virol. |volume=66 |issue= 8 |pages= 4705–9 |year= 1992 |pmid= 1629950 |doi= | pmc=241296 }}
*{{cite journal  | author=Wang D, Villasante A, Lewis SA, Cowan NJ |title=The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. |journal=J. Cell Biol. |volume=103 |issue= 5 |pages= 1903-10 |year= 1987 |pmid= 3782288 |doi= }}
*{{cite journal  | vauthors=Wang D, Villasante A, Lewis SA, Cowan NJ |title=The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype |journal=J. Cell Biol. |volume=103 |issue= 5 |pages= 1903–10 |year= 1987 |pmid= 3782288 |doi=10.1083/jcb.103.5.1903  | pmc=2114403  }}
*{{cite journal  | author=Lee MG, Lewis SA, Wilde CD, Cowan NJ |title=Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes. |journal=Cell |volume=33 |issue= 2 |pages= 477-87 |year= 1983 |pmid= 6688039 |doi=  }}
*{{cite journal  | vauthors=Lee MG, Lewis SA, Wilde CD, Cowan NJ |title=Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes |journal=Cell |volume=33 |issue= 2 |pages= 477–87 |year= 1983 |pmid= 6688039 |doi=10.1016/0092-8674(83)90429-4 }}
*{{cite journal | author=Takahashi M, Tomizawa K, Sato K, ''et al.'' |title=A novel tau-tubulin kinase from bovine brain. |journal=FEBS Lett. |volume=372 |issue= 1 |pages= 59-64 |year= 1995 |pmid= 7556643 |doi=  }}
*{{cite journal   |vauthors=Takahashi M, Tomizawa K, Sato K, etal |title=A novel tau-tubulin kinase from bovine brain |journal=FEBS Lett. |volume=372 |issue= 1 |pages= 59–64 |year= 1995 |pmid= 7556643 |doi=10.1016/0014-5793(95)00955-9 }}
*{{cite journal  | author=Yamaguchi N, Fukuda MN |title=Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins. |journal=J. Biol. Chem. |volume=270 |issue= 20 |pages= 12170-6 |year= 1995 |pmid= 7744867 |doi=  }}
*{{cite journal  | vauthors=Yamaguchi N, Fukuda MN |title=Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins |journal=J. Biol. Chem. |volume=270 |issue= 20 |pages= 12170–6 |year= 1995 |pmid= 7744867 |doi=  10.1074/jbc.270.33.19551}}
*{{cite journal  | author=Waterman-Storer CM, Karki S, Holzbaur EL |title=The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1634-8 |year= 1995 |pmid= 7878030 |doi= }}
*{{cite journal  | vauthors=Waterman-Storer CM, Karki S, Holzbaur EL |title=The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1) |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1634–8 |year= 1995 |pmid= 7878030 |doi=10.1073/pnas.92.5.1634  | pmc=42574  }}
*{{cite journal  | author=Carr D, Knull H |title=Aldolase-tubulin interactions: removal of tubulin C-terminals impairs interactions. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 1 |pages= 289-93 |year= 1993 |pmid= 8103323 |doi= 10.1006/bbrc.1993.2043 }}
*{{cite journal  | vauthors=Carr D, Knull H |title=Aldolase-tubulin interactions: removal of tubulin C-terminals impairs interactions |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 1 |pages= 289–93 |year= 1993 |pmid= 8103323 |doi= 10.1006/bbrc.1993.2043 }}
*{{cite journal  | author=Volz A, Weiss E, Trowsdale J, Ziegler A |title=Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction. |journal=Hum. Genet. |volume=93 |issue= 1 |pages= 42-6 |year= 1994 |pmid= 8270253 |doi=  }}
*{{cite journal  | vauthors=Volz A, Weiss E, Trowsdale J, Ziegler A |title=Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction |journal=Hum. Genet. |volume=93 |issue= 1 |pages= 42–6 |year= 1994 |pmid= 8270253 |doi=10.1007/BF00218911 }}
*{{cite journal | author=Paschal BM, Holzbaur EL, Pfister KK, ''et al.'' |title=Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin. |journal=J. Biol. Chem. |volume=268 |issue= 20 |pages= 15318-23 |year= 1993 |pmid= 8325901 |doi=  }}
*{{cite journal   |vauthors=Paschal BM, Holzbaur EL, Pfister KK, etal |title=Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin |journal=J. Biol. Chem. |volume=268 |issue= 20 |pages= 15318–23 |year= 1993 |pmid= 8325901 |doi=  }}
*{{cite journal  | author=Linhartová I, Dráberová E, Viklický V, Dráber P |title=Distribution of non-class-III beta-tubulin isoforms in neuronal and non-neuronal cells. |journal=FEBS Lett. |volume=320 |issue= 1 |pages= 79-82 |year= 1993 |pmid= 8462682 |doi=  }}
*{{cite journal  | vauthors=Linhartová I, Dráberová E, Viklický V, Dráber P |title=Distribution of non-class-III beta-tubulin isoforms in neuronal and non-neuronal cells |journal=FEBS Lett. |volume=320 |issue= 1 |pages= 79–82 |year= 1993 |pmid= 8462682 |doi=10.1016/0014-5793(93)81662-J }}
*{{cite journal  | author=Huby RD, Carlile GW, Ley SC |title=Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells. |journal=J. Biol. Chem. |volume=270 |issue= 51 |pages= 30241-4 |year= 1996 |pmid= 8530437 |doi=  }}
*{{cite journal  | vauthors=Huby RD, Carlile GW, Ley SC |title=Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells |journal=J. Biol. Chem. |volume=270 |issue= 51 |pages= 30241–4 |year= 1996 |pmid= 8530437 |doi=10.1074/jbc.270.51.30241 }}
*{{cite journal | author=Bosc C, Cronk JD, Pirollet F, ''et al.'' |title=Cloning, expression, and properties of the microtubule-stabilizing protein STOP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 5 |pages= 2125-30 |year= 1996 |pmid= 8700896 |doi=  }}
*{{cite journal   |vauthors=Bosc C, Cronk JD, Pirollet F, etal |title=Cloning, expression, and properties of the microtubule-stabilizing protein STOP |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 5 |pages= 2125–30 |year= 1996 |pmid= 8700896 |doi=10.1073/pnas.93.5.2125  | pmc=39921 }}
*{{cite journal | author=Tian G, Huang Y, Rommelaere H, ''et al.'' |title=Pathway leading to correctly folded beta-tubulin. |journal=Cell |volume=86 |issue= 2 |pages= 287-96 |year= 1996 |pmid= 8706133 |doi= }}
*{{cite journal   |vauthors=Tian G, Huang Y, Rommelaere H, etal |title=Pathway leading to correctly folded beta-tubulin |journal=Cell |volume=86 |issue= 2 |pages= 287–96 |year= 1996 |pmid= 8706133 |doi=10.1016/S0092-8674(00)80100-2  }}
*{{cite journal  | author=Tokito MK, Howland DS, Lee VM, Holzbaur EL |title=Functionally distinct isoforms of dynactin are expressed in human neurons. |journal=Mol. Biol. Cell |volume=7 |issue= 8 |pages= 1167-80 |year= 1997 |pmid= 8856662 |doi=  }}
*{{cite journal  | vauthors=Tokito MK, Howland DS, Lee VM, Holzbaur EL |title=Functionally distinct isoforms of dynactin are expressed in human neurons |journal=Mol. Biol. Cell |volume=7 |issue= 8 |pages= 1167–80 |year= 1997 |pmid= 8856662 |doi= 10.1091/mbc.7.8.1167| pmc=275970 }}
*{{cite journal | author=Kinnunen T, Kaksonen M, Saarinen J, ''et al.'' |title=Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. |journal=J. Biol. Chem. |volume=273 |issue= 17 |pages= 10702-8 |year= 1998 |pmid= 9553134 |doi=  }}
*{{cite journal   |vauthors=Kinnunen T, Kaksonen M, Saarinen J, etal |title=Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth |journal=J. Biol. Chem. |volume=273 |issue= 17 |pages= 10702–8 |year= 1998 |pmid= 9553134 |doi=10.1074/jbc.273.17.10702 }}
*{{cite journal | author=Niethammer M, Valtschanoff JG, Kapoor TM, ''et al.'' |title=CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. |journal=Neuron |volume=20 |issue= 4 |pages= 693-707 |year= 1998 |pmid= 9581762 |doi=  }}
*{{cite journal   |vauthors=Niethammer M, Valtschanoff JG, Kapoor TM, etal |title=CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90 |journal=Neuron |volume=20 |issue= 4 |pages= 693–707 |year= 1998 |pmid= 9581762 |doi=10.1016/S0896-6273(00)81009-0 }}
*{{cite journal | author=Rasmussen RK, Ji H, Eddes JS, ''et al.'' |title=Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins. |journal=Electrophoresis |volume=19 |issue= 5 |pages= 809-17 |year= 1998 |pmid= 9629920 |doi= 10.1002/elps.1150190535 }}
*{{cite journal   |vauthors=Rasmussen RK, Ji H, Eddes JS, etal |title=Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins |journal=Electrophoresis |volume=19 |issue= 5 |pages= 809–17 |year= 1998 |pmid= 9629920 |doi= 10.1002/elps.1150190535 }}
*{{cite journal  | author=Ciruela F, Robbins MJ, Willis AC, McIlhinney RA |title=Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins: evidence for a direct interaction with tubulin. |journal=J. Neurochem. |volume=72 |issue= 1 |pages= 346-54 |year= 1999 |pmid= 9886087 |doi=  }}
*{{cite journal  | vauthors=Ciruela F, Robbins MJ, Willis AC, McIlhinney RA |title=Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins: evidence for a direct interaction with tubulin |journal=J. Neurochem. |volume=72 |issue= 1 |pages= 346–54 |year= 1999 |pmid= 9886087 |doi=10.1046/j.1471-4159.1999.0720346.x }}
*{{cite journal | author=Chau MF, Radeke MJ, de Inés C, ''et al.'' |title=The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains. |journal=Biochemistry |volume=37 |issue= 51 |pages= 17692-703 |year= 1999 |pmid= 9922135 |doi=  }}
*{{cite journal   |vauthors=Chau MF, Radeke MJ, de Inés C, etal |title=The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains |journal=Biochemistry |volume=37 |issue= 51 |pages= 17692–703 |year= 1999 |pmid= 9922135 |doi=10.1021/bi9812118 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7280}}
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Latest revision as of 06:22, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tubulin beta-2A chain is a protein that in humans is encoded by the TUBB2A gene.[1][2]


References

  1. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S (Oct 2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
  2. "Entrez Gene: TUBB2A tubulin, beta 2A".

Further reading