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{{Infobox_gene}}
{{PBB_Controls
'''Trafficking kinesin-binding protein 2''' is a [[protein]] that in humans is encoded by the ''TRAK2'' [[gene]].<ref name="pmid11161814">{{cite journal | vauthors = Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR | title = Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2 | journal = Genomics | volume = 71 | issue = 2 | pages = 200–13 | date = Jan 2001 | pmid = 11161814 | pmc =  | doi = 10.1006/geno.2000.6392 }}</ref><ref name="pmid16380713">{{cite journal | vauthors = Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT | title = Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice | journal = Nature Genetics | volume = 38 | issue = 2 | pages = 245–50 | date = Feb 2006 | pmid = 16380713 | pmc = | doi = 10.1038/ng1715 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRAK2 trafficking protein, kinesin binding 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=66008| accessdate = }}</ref>
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| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Trafficking protein, kinesin binding 2
| HGNCid = 13206
| Symbol = TRAK2
| AltSymbols =; ALS2CR3; CALS-C; GRIF-1; GRIF1; KIAA0549; OIP98
| OMIM = 607334
| ECnumber = 
| Homologene = 22861
| MGIid = 1918077
| GeneAtlas_image1 = PBB_GE_TRAK2_202125_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TRAK2_202124_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005478 |text = transporter activity}} {{GNF_GO|id=GO:0050811 |text = GABA receptor binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006836 |text = neurotransmitter transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 66008
    | Hs_Ensembl = ENSG00000115993
    | Hs_RefseqProtein = NP_055864
    | Hs_RefseqmRNA = NM_015049
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 201950176
    | Hs_GenLoc_end = 202024499
    | Hs_Uniprot = O60296
    | Mm_EntrezGene = 70827
    | Mm_Ensembl = ENSMUSG00000026028
    | Mm_RefseqmRNA = XM_987233
    | Mm_RefseqProtein = XP_992327
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 58844996
    | Mm_GenLoc_end = 58917976
    | Mm_Uniprot = 
  }}
}}
'''Trafficking protein, kinesin binding 2''', also known as '''TRAK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TRAK2 trafficking protein, kinesin binding 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=66008| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
TRAK2 has been shown to [[Protein-protein interaction|interact]] with [[Kir2.1]]<ref name=pmid16895905>{{cite journal | vauthors = Grishin A, Li H, Levitan ES, Zaks-Makhina E | title = Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 40 | pages = 30104–11 | date = Oct 2006 | pmid = 16895905 | doi = 10.1074/jbc.M602439200 }}</ref> and [[GABRB2]].<ref name=pmid12034717>{{cite journal | vauthors = Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA | title = Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30079–90 | date = Aug 2002 | pmid = 12034717 | doi = 10.1074/jbc.M200438200 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 1 | pages = 31–9 | date = Feb 1998 | pmid = 9628581 | doi = 10.1093/dnares/5.1.31 }}
| citations =
* {{cite journal | vauthors = Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilariño Güell C, Aldred M, Brannon CA, Trembath RC, Nichols WC | title = A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium | journal = Genomics | volume = 68 | issue = 2 | pages = 220–8 | date = Sep 2000 | pmid = 10964520 | doi = 10.1006/geno.2000.6291 }}
*{{cite journal | author=Nagase T, Ishikawa K, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi= }}
* {{cite journal | vauthors = Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA | title = Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30079–90 | date = Aug 2002 | pmid = 12034717 | doi = 10.1074/jbc.M200438200 }}
*{{cite journal | author=Machado RD, Pauciulo MW, Fretwell N, ''et al.'' |title=A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium. |journal=Genomics |volume=68 |issue= 2 |pages= 220-8 |year= 2001 |pmid= 10964520 |doi= 10.1006/geno.2000.6291 }}
* {{cite journal | vauthors = Iyer SP, Akimoto Y, Hart GW | title = Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase | journal = The Journal of Biological Chemistry | volume = 278 | issue = 7 | pages = 5399–409 | date = Feb 2003 | pmid = 12435728 | doi = 10.1074/jbc.M209384200 }}
*{{cite journal | author=Hadano S, Yanagisawa Y, Skaug J, ''et al.'' |title=Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. |journal=Genomics |volume=71 |issue= 2 |pages= 200-13 |year= 2001 |pmid= 11161814 |doi= 10.1006/geno.2000.6392 }}
* {{cite journal | vauthors = Brickley K, Smith MJ, Beck M, Stephenson FA | title = GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin | journal = The Journal of Biological Chemistry | volume = 280 | issue = 15 | pages = 14723–32 | date = Apr 2005 | pmid = 15644324 | doi = 10.1074/jbc.M409095200 }}
*{{cite journal  | author=Beck M, Brickley K, Wilkinson HL, ''et al.'' |title=Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30079-90 |year= 2002 |pmid= 12034717 |doi= 10.1074/jbc.M200438200 }}
* {{cite journal | vauthors = Fransson S, Ruusala A, Aspenström P | title = The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking | journal = Biochemical and Biophysical Research Communications | volume = 344 | issue = 2 | pages = 500–10 | date = Jun 2006 | pmid = 16630562 | doi = 10.1016/j.bbrc.2006.03.163 }}
*{{cite journal | author=Iyer SP, Akimoto Y, Hart GW |title=Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 5399-409 |year= 2003 |pmid= 12435728 |doi= 10.1074/jbc.M209384200 }}
* {{cite journal | vauthors = Smith MJ, Pozo K, Brickley K, Stephenson FA | title = Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes | journal = The Journal of Biological Chemistry | volume = 281 | issue = 37 | pages = 27216–28 | date = Sep 2006 | pmid = 16835241 | doi = 10.1074/jbc.M600522200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Grishin A, Li H, Levitan ES, Zaks-Makhina E | title = Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 40 | pages = 30104–11 | date = Oct 2006 | pmid = 16895905 | doi = 10.1074/jbc.M602439200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Brickley K, Smith MJ, Beck M, Stephenson FA |title=GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 14723-32 |year= 2005 |pmid= 15644324 |doi= 10.1074/jbc.M409095200 }}
*{{cite journal | author=Gilbert SL, Zhang L, Forster ML, ''et al.'' |title=Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. |journal=Nat. Genet. |volume=38 |issue= 2 |pages= 245-50 |year= 2006 |pmid= 16380713 |doi= 10.1038/ng1715 }}
*{{cite journal  | author=Fransson S, Ruusala A, Aspenström P |title=The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 2 |pages= 500-10 |year= 2006 |pmid= 16630562 |doi= 10.1016/j.bbrc.2006.03.163 }}
*{{cite journal | author=Smith MJ, Pozo K, Brickley K, Stephenson FA |title=Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes. |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 27216-28 |year= 2006 |pmid= 16835241 |doi= 10.1074/jbc.M600522200 }}
*{{cite journal | author=Grishin A, Li H, Levitan ES, Zaks-Makhina E |title=Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1. |journal=J. Biol. Chem. |volume=281 |issue= 40 |pages= 30104-11 |year= 2006 |pmid= 16895905 |doi= 10.1074/jbc.M602439200 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:42, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Trafficking kinesin-binding protein 2 is a protein that in humans is encoded by the TRAK2 gene.[1][2][3]

Interactions

TRAK2 has been shown to interact with Kir2.1[4] and GABRB2.[5]

References

  1. ↑ Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (Jan 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics. 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
  2. ↑ Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Feb 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nature Genetics. 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713.
  3. ↑ "Entrez Gene: TRAK2 trafficking protein, kinesin binding 2".
  4. ↑ Grishin A, Li H, Levitan ES, Zaks-Makhina E (Oct 2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1". The Journal of Biological Chemistry. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905.
  5. ↑ Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". The Journal of Biological Chemistry. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.

Further reading

  • Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  • Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilariño Güell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (Sep 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
  • Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". The Journal of Biological Chemistry. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.
  • Iyer SP, Akimoto Y, Hart GW (Feb 2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase". The Journal of Biological Chemistry. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
  • Brickley K, Smith MJ, Beck M, Stephenson FA (Apr 2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin". The Journal of Biological Chemistry. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
  • Fransson S, Ruusala A, Aspenström P (Jun 2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking". Biochemical and Biophysical Research Communications. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.
  • Smith MJ, Pozo K, Brickley K, Stephenson FA (Sep 2006). "Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes". The Journal of Biological Chemistry. 281 (37): 27216–28. doi:10.1074/jbc.M600522200. PMID 16835241.
  • Grishin A, Li H, Levitan ES, Zaks-Makhina E (Oct 2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1". The Journal of Biological Chemistry. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905.


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