View source for TNNI3K

{{Infobox_gene}}
'''TNNI3 interacting kinase''' is a [[protein]] that in humans is encoded by the TNNI3K [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TNNI3 interacting kinase | url = https://www.ncbi.nlm.nih.gov/gene/51086 }}</ref>

== Function ==

This gene encodes a protein that belongs to the [[MAP kinase kinase kinase]] (MAPKKK) family of protein kinases. The protein contains [[ankyrin repeat]], [[protein kinase]] and serine-rich domains and is thought to play a role in cardiac physiology.<ref name="entrez"/>

== Clinical significance==

Mutations in TNNI3K are associated to {{SWL|type=mutations_associated_to|target=cardiomyopathy|label=cardiomyopathies}}.<ref>{{cite journal | vauthors = Theis JL, Zimmermann MT, Larsen BT, Rybakova IN, Long PA, Evans JM, Middha S, de Andrade M, Moss RL, Wieben ED, Michels VV, Olson TM | title = TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy | journal = Human Molecular Genetics | volume = 23 | issue = 21 | pages = 5793–804 | date = Nov 2014 | pmid = 24925317 | doi = 10.1093/hmg/ddu297 | pmc=4189907}}</ref>

== References ==
{{reflist}}

== Further reading ==

{{refbegin | 2}}
* {{cite journal | vauthors = Yang SW, Hitz MP, Andelfinger G | title = Ventricular septal defect and restrictive cardiomyopathy in a paediatric TNNI3 mutation carrier | journal = Cardiology in the Young | volume = 20 | issue = 5 | pages = 574–6 | date = Oct 2010 | pmid = 20569525 | doi = 10.1017/S1047951110000715 }}
* {{cite journal | vauthors = Wang L, Wang H, Ye J, Xu RX, Song L, Shi N, Zhang YW, Chen X, Meng XM | title = Adenovirus-mediated overexpression of cardiac troponin I-interacting kinase promotes cardiomyocyte hypertrophy | journal = Clinical and Experimental Pharmacology & Physiology | volume = 38 | issue = 4 | pages = 278–84 | date = Apr 2011 | pmid = 21314842 | doi = 10.1111/j.1440-1681.2011.05499.x }}
* {{cite journal | vauthors = Wei YJ, Cui CJ, Huang YX, Zhang XL, Zhang H, Hu SS | title = Upregulated expression of cardiac ankyrin repeat protein in human failing hearts due to arrhythmogenic right ventricular cardiomyopathy | journal = European Journal of Heart Failure | volume = 11 | issue = 6 | pages = 559–66 | date = Jun 2009 | pmid = 19359327 | doi = 10.1093/eurjhf/hfp049 }}
* {{cite journal | vauthors = Chen X, Li X, Wang P, Liu Y, Zhang Z, Zhao G, Xu H, Zhu J, Qin X, Chen S, Hu L, Kong X | title = Novel association strategy with copy number variation for identifying new risk Loci of human diseases | journal = PLOS ONE | volume = 5 | issue = 8 | pages = e12185 | year = 2010 | pmid = 20808825 | pmc = 2924882 | doi = 10.1371/journal.pone.0012185 }}
* {{cite journal | vauthors = Tang H, Xiao K, Mao L, Rockman HA, Marchuk DA | title = Overexpression of TNNI3K, a cardiac-specific MAPKKK, promotes cardiac dysfunction | journal = Journal of Molecular and Cellular Cardiology | volume = 54 | pages = 101–11 | date = Jan 2013 | pmid = 23085512 | pmc = 3535516 | doi = 10.1016/j.yjmcc.2012.10.004 }}
* {{cite journal | vauthors = Lai ZF, Chen YZ, Feng LP, Meng XM, Ding JF, Wang LY, Ye J, Li P, Cheng XS, Kitamoto Y, Monzen K, Komuro I, Sakaguchi N, Kim-Mitsuyama S | title = Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury | journal = American Journal of Physiology. Heart and Circulatory Physiology | volume = 295 | issue = 2 | pages = H708–16 | date = Aug 2008 | pmid = 18552163 | doi = 10.1152/ajpheart.00252.2008 }}
* {{cite journal | vauthors = Feng Y, Cao HQ, Liu Z, Ding JF, Meng XM | title = Identification of the dual specificity and the functional domains of the cardiac-specific protein kinase TNNI3K | journal = General Physiology and Biophysics | volume = 26 | issue = 2 | pages = 104–9 | date = Jun 2007 | pmid = 17660584 }}
* {{cite journal | vauthors = Feng Y, Liu DQ, Wang Z, Liu Z, Cao HQ, Wang LY, Shi N, Meng XM | title = AOP-1 interacts with cardiac-specific protein kinase TNNI3K and down-regulates its kinase activity | journal = Biochemistry. Biokhimiia | volume = 72 | issue = 11 | pages = 1199–204 | date = Nov 2007 | pmid = 18205602 | doi = 10.1134/s0006297907110053 }}
* {{cite journal | vauthors = Cousminer DL, Berry DJ, Timpson NJ, Ang W, Thiering E, Byrne EM, Taal HR, Huikari V, Bradfield JP, Kerkhof M, Groen-Blokhuis MM, Kreiner-Møller E, Marinelli M, Holst C, Leinonen JT, Perry JR, Surakka I, Pietiläinen O, Kettunen J, Anttila V, Kaakinen M, Sovio U, Pouta A, Das S, Lagou V, Power C, Prokopenko I, Evans DM, Kemp JP, St Pourcain B, Ring S, Palotie A, Kajantie E, Osmond C, Lehtimäki T, Viikari JS, Kähönen M, Warrington NM, Lye SJ, Palmer LJ, Tiesler CM, Flexeder C, Montgomery GW, Medland SE, Hofman A, Hakonarson H, Guxens M, Bartels M, Salomaa V, Murabito JM, Kaprio J, Sørensen TI, Ballester F, Bisgaard H, Boomsma DI, Koppelman GH, Grant SF, Jaddoe VW, Martin NG, Heinrich J, Pennell CE, Raitakari OT, Eriksson JG, Smith GD, Hyppönen E, Järvelin MR, McCarthy MI, Ripatti S, Widén E | display-authors = 6 | title = Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity | journal = Human Molecular Genetics | volume = 22 | issue = 13 | pages = 2735–47 | date = Jul 2013 | pmid = 23449627 | pmc = 3674797 | doi = 10.1093/hmg/ddt104 }}

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