TLE1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.

Interactions

TLE1 has been shown to interact with:

• Glycoprotein 130,
• HES6,
• RUNX1,
• RUNX3,
• SIX3
• TLE2, and
• UTY.

Further reading

• Eastman Q, Grosschedl R (Apr 1999). "Regulation of LEF-1/TCF transcription factors by Wnt and other signals". Current Opinion in Cell Biology. 11 (2): 233–40. doi:10.1016/S0955-0674(99)80031-3. PMID 10209158.
• Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S (Oct 1992). "Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins". Nature Genetics. 2 (2): 119–27. doi:10.1038/ng1092-119. PMID 1303260.
• Grbavec D, Stifani S (Jun 1996). "Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif". Biochemical and Biophysical Research Communications. 223 (3): 701–5. doi:10.1006/bbrc.1996.0959. PMID 8687460.
• Husain J, Lo R, Grbavec D, Stifani S (Jul 1996). "Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functions". The Biochemical Journal. 317 (Pt 2): 523–31. doi:10.1042/bj3170523. PMC 1217518. PMID 8713081.
• Palaparti A, Baratz A, Stifani S (Oct 1997). "The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3". The Journal of Biological Chemistry. 272 (42): 26604–10. doi:10.1074/jbc.272.42.26604. PMID 9334241.
• Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y (Sep 1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11590–5. Bibcode:1998PNAS...9511590L. doi:10.1073/pnas.95.20.11590. PMC 21685. PMID 9751710.
• Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (Jan 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 (Pt 1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.
• Grbavec D, Lo R, Liu Y, Stifani S (Dec 1998). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". European Journal of Biochemistry / FEBS. 258 (2): 339–49. doi:10.1046/j.1432-1327.1998.2580339.x. PMID 9874198.
• Ren B, Chee KJ, Kim TH, Maniatis T (Jan 1999). "PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins". Genes & Development. 13 (1): 125–37. doi:10.1101/gad.13.1.125. PMC 316372. PMID 9887105.
• Tetsuka T, Uranishi H, Imai H, Ono T, Sonta S, Takahashi N, Asamitsu K, Okamoto T (Feb 2000). "Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats". The Journal of Biological Chemistry. 275 (6): 4383–90. doi:10.1074/jbc.275.6.4383. PMID 10660609.
• Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK (Jun 2000). "Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta". The Journal of Biological Chemistry. 275 (24): 18418–23. doi:10.1074/jbc.M910211199. PMID 10748198.
• Yao J, Lai E, Stifani S (Mar 2001). "The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription". Molecular and Cellular Biology. 21 (6): 1962–72. doi:10.1128/MCB.21.6.1962-1972.2001. PMC 86788. PMID 11238932.
• Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". The Journal of Cell Biology. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.
• Dasen JS, Martinez Barbera JP, Herman TS, Connell SO, Olson L, Ju B, Tollkuhn J, Baek SH, Rose DW, Rosenfeld MG (Dec 2001). "Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis". Genes & Development. 15 (23): 3193–207. doi:10.1101/gad.932601. PMC 312840. PMID 11731482.
• Dintilhac A, Bernués J (Mar 2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". The Journal of Biological Chemistry. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
• Liu F, Liu Y, Li D, Zhu Y, Ouyang W, Xie X, Jin B (Mar 2002). "The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain". Molecular and Cellular Biochemistry. 232 (1–2): 163–7. doi:10.1023/A:1014880813692. PMID 12030375.
• Pickles LM, Roe SM, Hemingway EJ, Stifani S, Pearl LH (Jun 2002). "Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor". Structure. 10 (6): 751–61. doi:10.1016/S0969-2126(02)00768-2. PMID 12057191.