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The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein-coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.[2]
↑Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H (Oct 1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia. 8 (10): 1663–72. PMID7934162.
↑Liang X, Wisniewski D, Strife A, Clarkson B, Resh MD (Apr 2002). "Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling". The Journal of Biological Chemistry. 277 (16): 13732–8. doi:10.1074/jbc.M200277200. PMID11825908.
↑Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID9178903.
↑Yamashita Y, Watanabe S, Miyazato A, Ohya Ki, Ikeda U, Shimada K, Komatsu N, Hatake K, Miura Y, Ozawa K, Mano H (Mar 1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood. 91 (5): 1496–507. PMID9473212.
↑Ohya Ki, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H (Oct 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". The Journal of Biological Chemistry. 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID9341160.
Further reading
Mano H (2000). "Tec family of protein-tyrosine kinases: an overview of their structure and function". Cytokine & Growth Factor Reviews. 10 (3–4): 267–80. doi:10.1016/S1359-6101(99)00019-2. PMID10647781.
Yang WC, Collette Y, Nunès JA, Olive D (Apr 2000). "Tec kinases: a family with multiple roles in immunity". Immunity. 12 (4): 373–82. doi:10.1016/S1074-7613(00)80189-2. PMID10795735.
Mano H, Ishikawa F, Nishida J, Hirai H, Takaku F (Dec 1990). "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver". Oncogene. 5 (12): 1781–6. PMID2284097.
Machide M, Mano H, Todokoro K (Aug 1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619–25. PMID7651724.
Mano H, Yamashita Y, Miyazato A, Miura Y, Ozawa K (Apr 1996). "Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase". FASEB Journal. 10 (5): 637–42. PMID8621063.
Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP (Feb 1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science. 271 (5250): 822–5. doi:10.1126/science.271.5250.822. PMID8629002.
Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON (May 1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain". Immunity. 4 (5): 515–25. doi:10.1016/S1074-7613(00)80417-3. PMID8630736.
Ohta Y, Haire RN, Amemiya CT, Litman RT, Träger T, Riess O, Litman GW (Feb 1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene. 12 (4): 937–42. PMID8632917.
Cory GO, MacCarthy-Morrogh L, Banin S, Gout I, Brickell PM, Levinsky RJ, Kinnon C, Lovering RC (Nov 1996). "Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways". Journal of Immunology. 157 (9): 3791–5. PMID8892607.
Takahashi-Tezuka M, Hibi M, Fujitani Y, Fukada T, Yamaguchi T, Hirano T (May 1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID9178903.
Laffargue M, Monnereau L, Tuech J, Ragab A, Ragab-Thomas J, Payrastre B, Raynal P, Chap H (Sep 1997). "Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets". Biochemical and Biophysical Research Communications. 238 (1): 247–51. doi:10.1006/bbrc.1997.7269. PMID9299487.
Kitanaka A, Mano H, Conley ME, Campana D (Feb 1998). "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells". Blood. 91 (3): 940–8. PMID9446655.
Yang WC, Ghiotto M, Barbarat B, Olive D (Jan 1999). "The role of Tec protein-tyrosine kinase in T cell signaling". The Journal of Biological Chemistry. 274 (2): 607–17. doi:10.1074/jbc.274.2.607. PMID9872994.