TEC (gene)

Tec protein tyrosine kinase
File:PBB Protein TEC image.jpg PDB rendering based on 1gl5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1gl5​
Identifiers
Symbols	TEC ; MGC126760; MGC126762; PSCTK4
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1302
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TEC 206301 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tec protein tyrosine kinase, also known as TEC, is a human gene.

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.

Further reading

• Mano H (2000). "Tec family of protein-tyrosine kinases: an overview of their structure and function". Cytokine Growth Factor Rev. 10 (3–4): 267–80. PMID 10647781.
• Yang WC, Collette Y, Nunès JA, Olive D (2000). "Tec kinases: a family with multiple roles in immunity". Immunity. 12 (4): 373–82. PMID 10795735.CS1 maint: Multiple names: authors list (link)
• Mano H, Ishikawa F, Nishida J; et al. (1991). "A novel protein-tyrosine kinase, tec, is preferentially expressed in liver". Oncogene. 5 (12): 1781–6. PMID 2284097.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tang B, Mano H, Yi T, Ihle JN (1994). "Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding". Mol. Cell. Biol. 14 (12): 8432–7. PMID 7526158.CS1 maint: Multiple names: authors list (link)
• Machide M, Mano H, Todokoro K (1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619–25. PMID 7651724.CS1 maint: Multiple names: authors list (link)
• Sato K, Mano H, Ariyama T; et al. (1994). "Molecular cloning and analysis of the human Tec protein-tyrosine kinase". Leukemia. 8 (10): 1663–72. PMID 7934162.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mano H, Yamashita Y, Miyazato A; et al. (1996). "Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase". FASEB J. 10 (5): 637–42. PMID 8621063.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rawlings DJ, Scharenberg AM, Park H; et al. (1996). "Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases". Science. 271 (5250): 822–5. PMID 8629002.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park H, Wahl MI, Afar DE; et al. (1996). "Regulation of Btk function by a major autophosphorylation site within the SH3 domain". Immunity. 4 (5): 515–25. PMID 8630736.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohta Y, Haire RN, Amemiya CT; et al. (1996). "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene". Oncogene. 12 (4): 937–42. PMID 8632917.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cory GO, MacCarthy-Morrogh L, Banin S; et al. (1996). "Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways". J. Immunol. 157 (9): 3791–5. PMID 8892607.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi-Tezuka M, Hibi M, Fujitani Y; et al. (1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laffargue M, Monnereau L, Tuech J; et al. (1997). "Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets". Biochem. Biophys. Res. Commun. 238 (1): 247–51. doi:10.1006/bbrc.1997.7269. PMID 9299487.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohya K, Kajigaya S, Yamashita Y; et al. (1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. 272 (43): 27178–82. PMID 9341160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kitanaka A, Mano H, Conley ME, Campana D (1998). "Expression and activation of the nonreceptor tyrosine kinase Tec in human B cells". Blood. 91 (3): 940–8. PMID 9446655.CS1 maint: Multiple names: authors list (link)
• Yamashita Y, Watanabe S, Miyazato A; et al. (1998). "Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription". Blood. 91 (5): 1496–507. PMID 9473212.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang WC, Ghiotto M, Barbarat B, Olive D (1999). "The role of Tec protein-tyrosine kinase in T cell signaling". J. Biol. Chem. 274 (2): 607–17. PMID 9872994.CS1 maint: Multiple names: authors list (link)
• Yang WC, Olive D (1999). "Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway". Eur. J. Immunol. 29 (6): 1842–9. PMID 10382746.
• Ohya K, Kajigaya S, Kitanaka A; et al. (1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11976–81. PMID 10518561.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)