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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Transcription elongation factor A protein 2''' is a [[protein]] that in humans is encoded by the ''TCEA2'' [[gene]].<ref name="pmid9441762">{{cite journal | vauthors = Weaver ZA, Kane CM | title = Genomic characterization of a testis-specific TFIIS (TCEA2) gene | journal = Genomics | volume = 46 | issue = 3 | pages = 516–9 | date = Dec 1997 | pmid = 9441762 | pmc = | doi = 10.1006/geno.1997.5073 }}</ref><ref name="pmid8566795">{{cite journal | vauthors = Umehara T, Kida S, Yamamoto T, Horikoshi M | title = Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II | journal = Gene | volume = 167 | issue = 1-2 | pages = 297–302 | date = Dec 1995 | pmid = 8566795 | pmc =  | doi = 10.1016/0378-1119(95)00634-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TCEA2 transcription elongation factor A (SII), 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6919| accessdate = }}</ref>
| image = PBB_Protein_TCEA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tfi.
| PDB = {{PDB2|1tfi}}
| Name = Transcription elongation factor A (SII), 2
| HGNCid = 11614
| Symbol = TCEA2
| AltSymbols =; TFIIS
| OMIM = 604784
| ECnumber = 
| Homologene = 68304
| MGIid = 107368
| GeneAtlas_image1 = PBB_GE_TCEA2_203919_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003711 |text = transcription elongation regulator activity}} {{GNF_GO|id=GO:0003746 |text = translation elongation factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0008023 |text = transcription elongation factor complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006354 |text = RNA elongation}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6919
    | Hs_Ensembl = ENSG00000171703
    | Hs_RefseqProtein = NP_003186
    | Hs_RefseqmRNA = NM_003195
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 62159090
    | Hs_GenLoc_end = 62174143
    | Hs_Uniprot = Q15560
    | Mm_EntrezGene = 21400
    | Mm_Ensembl = ENSMUSG00000059540
    | Mm_RefseqmRNA = NM_009326
    | Mm_RefseqProtein = NP_033352
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 181609716
    | Mm_GenLoc_end = 181617477
    | Mm_Uniprot = Q3UV78
  }}
}}
'''Transcription elongation factor A (SII), 2''', also known as '''TCEA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TCEA2 transcription elongation factor A (SII), 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6919| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: TCEA2 transcription elongation factor A (SII), 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6919| accessdate = }}</ref>
}}


==References==
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
TCEA2 has been shown to [[Protein-protein_interaction|interact]] with [[MAGEA11]].<ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG | title = HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors | journal = Genes & Development | volume = 6 | issue = 4 | pages = 655–66 | date = Apr 1992 | pmid = 1559613 | doi = 10.1101/gad.6.4.655 }}
| citations =
* {{cite journal | vauthors = Li XY, Green MR | title = The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor | journal = Genes & Development | volume = 12 | issue = 19 | pages = 2992–6 | date = Oct 1998 | pmid = 9765201 | pmc = 317190 | doi = 10.1101/gad.12.19.2992 }}
*{{cite journal | author=Kato H, Sumimoto H, Pognonec P, ''et al.'' |title=HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. |journal=Genes Dev. |volume=6 |issue= 4 |pages= 655-66 |year= 1992 |pmid= 1559613 |doi=  }}
* {{cite journal | vauthors = Trembley JH, Hu D, Hsu LC, Yeung CY, Slaughter C, Lahti JM, Kidd VJ | title = PITSLRE p110 protein kinases associate with transcription complexes and affect their activity | journal = The Journal of Biological Chemistry | volume = 277 | issue = 4 | pages = 2589–96 | date = Jan 2002 | pmid = 11709559 | doi = 10.1074/jbc.M109755200 }}
*{{cite journal  | author=Umehara T, Kida S, Yamamoto T, Horikoshi M |title=Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II. |journal=Gene |volume=167 |issue= 1-2 |pages= 297-302 |year= 1996 |pmid= 8566795 |doi=  }}
* {{cite journal | vauthors = Sijbrandi R, Fiedler U, Timmers HT | title = RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage | journal = Nucleic Acids Research | volume = 30 | issue = 11 | pages = 2290–8 | date = Jun 2002 | pmid = 12034815 | pmc = 117193 | doi = 10.1093/nar/30.11.2290 }}
*{{cite journal  | author=Weaver ZA, Kane CM |title=Genomic characterization of a testis-specific TFIIS (TCEA2) gene. |journal=Genomics |volume=46 |issue= 3 |pages= 516-9 |year= 1998 |pmid= 9441762 |doi= 10.1006/geno.1997.5073 }}
* {{cite journal | vauthors = Saso K, Ito T, Natori S, Sekimizu K | title = Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II | journal = Journal of Biochemistry | volume = 133 | issue = 4 | pages = 493–500 | date = Apr 2003 | pmid = 12761297 | doi = 10.1093/jb/mvg065 }}
*{{cite journal | author=Li XY, Green MR |title=The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor. |journal=Genes Dev. |volume=12 |issue= 19 |pages= 2992-6 |year= 1998 |pmid= 9765201 |doi= }}
* {{cite journal | vauthors = Tamura K, Miyata K, Sugahara K, Onishi S, Shuin T, Aso T | title = Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain | journal = Biochemical and Biophysical Research Communications | volume = 309 | issue = 1 | pages = 189–95 | date = Sep 2003 | pmid = 12943681 | doi = 10.1016/S0006-291X(03)01556-0 }}
*{{cite journal | author=Trembley JH, Hu D, Hsu LC, ''et al.'' |title=PITSLRE p110 protein kinases associate with transcription complexes and affect their activity. |journal=J. Biol. Chem. |volume=277 |issue= 4 |pages= 2589-96 |year= 2002 |pmid= 11709559 |doi= 10.1074/jbc.M109755200 }}
* {{cite journal | vauthors = Nakata A, Ito T, Nagata M, Hori S, Sekimizu K | title = GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1 | journal = Genes to Cells | volume = 9 | issue = 11 | pages = 1125–35 | date = Nov 2004 | pmid = 15507123 | doi = 10.1111/j.1365-2443.2004.00795.x }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal  | author=Sijbrandi R, Fiedler U, Timmers HT |title=RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage. |journal=Nucleic Acids Res. |volume=30 |issue= 11 |pages= 2290-8 |year= 2002 |pmid= 12034815 |doi=  }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Palangat M, Renner DB, Price DH, Landick R | title = A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 42 | pages = 15036–41 | date = Oct 2005 | pmid = 16214896 | pmc = 1257689 | doi = 10.1073/pnas.0409405102 }}
*{{cite journal | author=Saso K, Ito T, Natori S, Sekimizu K |title=Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II. |journal=J. Biochem. |volume=133 |issue= 4 |pages= 493-500 |year= 2004 |pmid= 12761297 |doi= }}
* {{cite journal | vauthors = Kuraoka I, Suzuki K, Ito S, Hayashida M, Kwei JS, Ikegami T, Handa H, Nakabeppu Y, Tanaka K | title = RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS | journal = DNA Repair | volume = 6 | issue = 6 | pages = 841–51 | date = Jun 2007 | pmid = 17374514 | doi = 10.1016/j.dnarep.2007.01.014 }}
*{{cite journal | author=Tamura K, Miyata K, Sugahara K, ''et al.'' |title=Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 1 |pages= 189-95 |year= 2003 |pmid= 12943681 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Nakata A, Ito T, Nagata M, ''et al.'' |title=GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1. |journal=Genes Cells |volume=9 |issue= 11 |pages= 1125-35 |year= 2005 |pmid= 15507123 |doi= 10.1111/j.1365-2443.2004.00795.x }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Palangat M, Renner DB, Price DH, Landick R |title=A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 42 |pages= 15036-41 |year= 2005 |pmid= 16214896 |doi= 10.1073/pnas.0409405102 }}
*{{cite journal | author=Kuraoka I, Suzuki K, Ito S, ''et al.'' |title=RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. |journal=DNA Repair (Amst.) |volume=6 |issue= 6 |pages= 841-51 |year= 2007 |pmid= 17374514 |doi= 10.1016/j.dnarep.2007.01.014 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=6919}}
{{WikiDoc Sources}}
 
{{gene-20-stub}}

Latest revision as of 16:14, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription elongation factor A protein 2 is a protein that in humans is encoded by the TCEA2 gene.[1][2][3]

Function

The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

TCEA2 has been shown to interact with MAGEA11.[4]

References

  1. ↑ Weaver ZA, Kane CM (Dec 1997). "Genomic characterization of a testis-specific TFIIS (TCEA2) gene". Genomics. 46 (3): 516–9. doi:10.1006/geno.1997.5073. PMID 9441762.
  2. ↑ Umehara T, Kida S, Yamamoto T, Horikoshi M (Dec 1995). "Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II". Gene. 167 (1–2): 297–302. doi:10.1016/0378-1119(95)00634-6. PMID 8566795.
  3. ↑ 3.0 3.1 "Entrez Gene: TCEA2 transcription elongation factor A (SII), 2".
  4. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

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