TBX21
| T-box 21 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | TBX21 ; T-PET; T-bet; TBET; TBLYM | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 8353 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE TBX21 220684 at tn.png | |||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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T-box 21, also known as TBX21, is a human gene.[1]
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.[1]
References
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Szabo SJ, Kim ST, Costa GL; et al. (2000). "A novel transcription factor, T-bet, directs Th1 lineage commitment". Cell. 100 (6): 655–69. PMID 10761931.
- Zhang WX, Yang SY (2001). "Cloning and characterization of a new member of the T-box gene family". Genomics. 70 (1): 41–8. doi:10.1006/geno.2000.6361. PMID 11087660.
- Faedo A, Ficara F, Ghiani M; et al. (2003). "Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis". Mech. Dev. 116 (1–2): 157–60. PMID 12128215.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Chung HT, Kim LH, Park BL; et al. (2003). "Association analysis of novel TBX21 variants with asthma phenotypes". Hum. Mutat. 22 (3): 257. doi:10.1002/humu.9169. PMID 12938094.
- Yu HR, Chang JC, Chen RF; et al. (2004). "Different antigens trigger different Th1/Th2 reactions in neonatal mononuclear cells (MNCs) relating to T-bet/GATA-3 expression". J. Leukoc. Biol. 74 (5): 952–8. doi:10.1189/jlb.0902474. PMID 12960249.
- Lametschwandtner G, Biedermann T, Schwärzler C; et al. (2004). "Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities". J. Allergy Clin. Immunol. 113 (5): 987–94. doi:10.1016/j.jaci.2004.02.004. PMID 15131585.
- Sasaki Y, Ihara K, Matsuura N; et al. (2004). "Identification of a novel type 1 diabetes susceptibility gene, T-bet". Hum. Genet. 115 (3): 177–84. doi:10.1007/s00439-004-1146-2. PMID 15241679.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Tantisira KG, Hwang ES, Raby BA; et al. (2005). "TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids". Proc. Natl. Acad. Sci. U.S.A. 101 (52): 18099–104. doi:10.1073/pnas.0408532102. PMID 15604153.
- Atayar C, Poppema S, Blokzijl T; et al. (2005). "Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas". Am. J. Pathol. 166 (1): 127–34. PMID 15632006.
- Tong Y, Aune T, Boothby M (2005). "T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site". Proc. Natl. Acad. Sci. U.S.A. 102 (6): 2034–9. doi:10.1073/pnas.0409510102. PMID 15684083.
- Dorfman DM, Hwang ES, Shahsafaei A, Glimcher LH (2005). "T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma". Hum. Pathol. 36 (1): 10–5. doi:10.1016/j.humpath.2004.10.006. PMID 15712176.
- Kulkarni A, Ravi DS, Singh K; et al. (2005). "HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response". Biochem. Biophys. Res. Commun. 329 (2): 706–12. doi:10.1016/j.bbrc.2005.02.042. PMID 15737643.
- Akahoshi M, Obara K, Hirota T; et al. (2005). "Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma". Hum. Genet. 117 (1): 16–26. doi:10.1007/s00439-005-1285-0. PMID 15806396.
- Kawana K, Kawana Y, Schust DJ (2005). "Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract". Mol. Endocrinol. 19 (8): 2047–59. doi:10.1210/me.2004-0489. PMID 15860546.
- Harashima A, Matsuo Y, Drexler HG; et al. (2005). "Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet". Leuk. Res. 29 (7): 841–8. doi:10.1016/j.leukres.2004.12.010. PMID 15927679.
- Raby BA, Hwang ES, Van Steen K; et al. (2006). "T-bet polymorphisms are associated with asthma and airway hyperresponsiveness". Am. J. Respir. Crit. Care Med. 173 (1): 64–70. doi:10.1164/rccm.200503-505OC. PMID 16179640.
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