TAF1A: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''TATA box-binding protein-associated factor RNA polymerase I subunit A''' is an [[enzyme]] that in humans is encoded by the ''TAF1A'' [[gene]].<ref name="pmid7801123">{{cite journal | vauthors = Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R | title = Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits | journal = Science | volume = 266 | issue = 5193 | pages = 1966–72 | year = 1994 | date = January 1995 | pmid = 7801123 | pmc =  | doi = 10.1126/science.7801123 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9015| accessdate = }}</ref>
'''TATA box-binding protein-associated factor RNA polymerase I subunit A''' is an [[enzyme]] that in humans is encoded by the ''TAF1A'' [[gene]].<ref name="pmid7801123">{{cite journal | vauthors = Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R | title = Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits | journal = Science | volume = 266 | issue = 5193 | pages = 1966–72 | date = December 1994 | pmid = 7801123 | pmc =  | doi = 10.1126/science.7801123 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9015| accessdate = }}</ref>


== Function ==
== Function ==

Latest revision as of 12:27, 20 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.[1][2]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[2]

Interactions

TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A[3] and Protein SET.[3]

References

  1. ↑ Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (December 1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123.
  2. ↑ 2.0 2.1 "Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa".
  3. ↑ 3.0 3.1 Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.

Further reading


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