TAF1A: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''TATA box-binding protein-associated factor RNA polymerase I subunit A''' is an [[enzyme]] that in humans is encoded by the ''TAF1A'' [[gene]].<ref name="pmid7801123">{{cite journal | vauthors = Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R | title = Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits | journal = Science | volume = 266 | issue = 5193 | pages = 1966–72 | date = December 1994  | pmid = 7801123 | pmc =  | doi = 10.1126/science.7801123 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9015| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
| HGNCid = 11532
| Symbol = TAF1A
| AltSymbols =; SL1; MGC:17061; RAFI48; TAFI48
| OMIM = 604903
| ECnumber = 
| Homologene = 4155
| MGIid = 
| GeneAtlas_image1 = PBB_GE_TAF1A_206613_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003701 |text = RNA polymerase I transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016251 |text = general RNA polymerase II transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006360 |text = transcription from RNA polymerase I promoter}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9015
    | Hs_Ensembl = ENSG00000143498
    | Hs_RefseqProtein = NP_005672
    | Hs_RefseqmRNA = NM_005681
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 220797867
    | Hs_GenLoc_end = 220829878
    | Hs_Uniprot = Q15573
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa''', also known as '''TAF1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9015| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9015| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Comai L, Zomerdijk JC, Beckmann H, ''et al.'' |title=Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. |journal=Science |volume=266 |issue= 5193 |pages= 1966-72 |year= 1995 |pmid= 7801123 |doi=  }}
*{{cite journal  | author=Rudloff U, Eberhard D, Tora L, ''et al.'' |title=TBP-associated factors interact with DNA and govern species specificity of RNA polymerase I transcription. |journal=EMBO J. |volume=13 |issue= 11 |pages= 2611-6 |year= 1994 |pmid= 8013460 |doi=  }}
*{{cite journal  | author=Di Pietro C, Rapisarda A, Amico V, ''et al.'' |title=Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1-2 |pages= 133-6 |year= 2000 |pmid= 10894955 |doi=  }}
*{{cite journal  | author=Zhai W, Comai L |title=Repression of RNA polymerase I transcription by the tumor suppressor p53. |journal=Mol. Cell. Biol. |volume=20 |issue= 16 |pages= 5930-8 |year= 2000 |pmid= 10913176 |doi=  }}
*{{cite journal  | author=Seo SB, McNamara P, Heo S, ''et al.'' |title=Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. |journal=Cell |volume=104 |issue= 1 |pages= 119-30 |year= 2001 |pmid= 11163245 |doi=  }}
*{{cite journal  | author=Miller G, Panov KI, Friedrich JK, ''et al.'' |title=hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. |journal=EMBO J. |volume=20 |issue= 6 |pages= 1373-82 |year= 2001 |pmid= 11250903 |doi= 10.1093/emboj/20.6.1373 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Dynes JL, Xu S, Bothner S, ''et al.'' |title=The carboxyl-terminus directs TAF(I)48 to the nucleus and nucleolus and associates with multiple nuclear import receptors. |journal=J. Biochem. |volume=135 |issue= 3 |pages= 429-38 |year= 2005 |pmid= 15113842 |doi=  }}
*{{cite journal  | author=Yamamoto K, Yamamoto M, Hanada K, ''et al.'' |title=Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. |journal=Mol. Cell. Biol. |volume=24 |issue= 14 |pages= 6338-49 |year= 2004 |pmid= 15226435 |doi= 10.1128/MCB.24.14.6338-6349.2004 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Grandori C, Gomez-Roman N, Felton-Edkins ZA, ''et al.'' |title=c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. |journal=Nat. Cell Biol. |volume=7 |issue= 3 |pages= 311-8 |year= 2005 |pmid= 15723054 |doi= 10.1038/ncb1224 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}


{{protein-stub}}
TAF1A has been shown to [[Protein-protein interaction|interact]] with [[Acidic leucine-rich nuclear phosphoprotein 32 family member A]]<ref name=pmid11163245>{{cite journal | vauthors = Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D | title = Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein | journal = Cell | volume = 104 | issue = 1 | pages = 119–30  | date = January 2001 | pmid = 11163245 | doi = 10.1016/S0092-8674(01)00196-9 }}</ref> and [[Protein SET]].<ref name=pmid11163245/>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Rudloff U, Eberhard D, Tora L, Stunnenberg H, Grummt I | title = TBP-associated factors interact with DNA and govern species specificity of RNA polymerase I transcription | journal = EMBO J. | volume = 13 | issue = 11 | pages = 2611–6 | year = 1994 | pmid = 8013460 | pmc = 395135 | doi =  }}
* {{cite journal | vauthors = Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M | title = Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1 | journal = Cytogenet. Cell Genet. | volume = 89 | issue = 1-2 | pages = 133–6 | year = 2000 | pmid = 10894955 | doi = 10.1159/000015592 }}
* {{cite journal | vauthors = Zhai W, Comai L | title = Repression of RNA polymerase I transcription by the tumor suppressor p53 | journal = Mol. Cell. Biol. | volume = 20 | issue = 16 | pages = 5930–8 | year = 2000 | pmid = 10913176 | pmc = 86070 | doi = 10.1128/MCB.20.16.5930-5938.2000 }}
* {{cite journal | vauthors = Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D | title = Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein | journal = Cell | volume = 104 | issue = 1 | pages = 119–30 | year = 2001 | pmid = 11163245 | doi = 10.1016/S0092-8674(01)00196-9 }}
* {{cite journal | vauthors = Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC | title = hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1373–82 | year = 2001 | pmid = 11250903 | pmc = 145519 | doi = 10.1093/emboj/20.6.1373 }}
* {{cite journal | vauthors = Dynes JL, Xu S, Bothner S, Lahti JM, Hori RT | title = The carboxyl-terminus directs TAF(I)48 to the nucleus and nucleolus and associates with multiple nuclear import receptors | journal = J. Biochem. | volume = 135 | issue = 3 | pages = 429–38 | year = 2004 | pmid = 15113842 | doi = 10.1093/jb/mvh051 }}
* {{cite journal | vauthors = Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M | title = Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription | journal = Mol. Cell. Biol. | volume = 24 | issue = 14 | pages = 6338–49 | year = 2004 | pmid = 15226435 | pmc = 434256 | doi = 10.1128/MCB.24.14.6338-6349.2004 }}
* {{cite journal | vauthors = Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ | title = c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I | journal = Nat. Cell Biol. | volume = 7 | issue = 3 | pages = 311–8 | year = 2005 | pmid = 15723054 | doi = 10.1038/ncb1224 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
{{Refend}}
 
 
{{Gene-1-stub}}

Latest revision as of 12:27, 20 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.[1][2]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[2]

Interactions

TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A[3] and Protein SET.[3]

References

  1. ↑ Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (December 1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123.
  2. ↑ 2.0 2.1 "Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa".
  3. ↑ 3.0 3.1 Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.

Further reading


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